A5003015144- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Birth, Development, and Health
- Neurotransmitter Receptor Influence on Behavior
- Epigenetics and DNA Methylation
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Hormonal and reproductive studies
- Muscle metabolism and nutrition
- Hemoglobinopathies and Related Disorders
- Non-Invasive Vital Sign Monitoring
- Traumatic Brain Injury and Neurovascular Disturbances
- Diet and metabolism studies
- Functional Brain Connectivity Studies
- Cardiovascular Health and Disease Prevention
- Hemoglobin structure and function
- Cardiovascular Syncope and Autonomic Disorders
- Adipose Tissue and Metabolism
- Cardiac Ischemia and Reperfusion
American University of Antigua
2016-2025
Bayhealth Foundation
2024
University of Illinois Chicago
2023-2024
University of Illinois Urbana-Champaign
2023
Illinois College
2023
Ohio University
2022-2023
Mercer University
2023
Howard University Hospital
1977-2023
Spartan Health Sciences University
2023
Louisiana State University Health Sciences Center Shreveport
2023
It is well known that opiate addiction a neurobiological disease associated with dysregulation of multiple neurotransmitters and neurochemicals. Previous ex-vivo 1H nuclear magnetic resonance (NMR) studies have yielded mixed findings concerning opiate-induced neurometabolic changes at key reward-addiction sites. Whether such reflect the conditions in live animal remains unknown. The present study was therefore designed to fill this knowledge gap by determining effects morphine-induced under...
The advent of internet-based delivery basic medical science lectures may unintentionally lead to decreased classroom attendance and participation, thereby creating a distance learning paradigm. In this study, we tested the hypothesis that attendance/participation be positively correlated with performance on written examination for first-year school instruction. study subjects consisted 115 students. introductory respiratory structure-function instruction was designed include one...
Cerebral blood flow dysregulation is often associated with hypertension. We hypothesized that a beetroot juice (BRJ) treatment could decrease pressure and cerebrovascular resistance (CVR). subjected 12 healthy females to control BRJ treatments. Cerebrovascular index (CVRI), systolic (SBP), total vascular (TVR), the heart rate-systolic product (RPP) measured at rest two exercise workloads were lower after treatment. CVRI, SBP, RPP without TVR highest level. These findings suggest improved...
The advent of medical nutrition therapy and nutritional physiology affords the opportunity to link diet specific cardiovascular mechanisms, suggesting novel treatments for disease. This study tests hypothesis that beetroot juice increases plasma nitric oxide (NO) concentration, which is associated with improvements in cardiorespiratory function at rest during submaximal aerobic exercise. subjects were 12 healthy, young adult, normotensive African-American females, a body mass 61 ± 2 kg, fat...
Several of the active compounds in foods, poisons, drugs, and industrial chemicals may, by epigenetic mechanisms, increase or decrease risk breast cancers. Enzymes that are involved DNA methylation histone modifications have been shown to be altered several types other cancers resulting abnormal patterns and/or acetylation. Hypermethylation at CpG islands found estrogen response element (ERE) promoters occurs conjunction with ligand-bonded alpha subunit receptor (Erα) dimers wherein ligand...
Previous studies have demonstrated positive-inotropic effects of calcitonin gene-related peptide (CGRP), but the mechanisms remain unclear. Therefore, two experiments were performed to determine physiological correlates CGRP. Treatments designed antagonize physiologically active CGRP₁₋₃₇ included posttreatment with CGRP₈₋₃₇ and pretreatment LY-294002 (LY, an inhibitor phosphatidylinositol 3-kinase), 17β-estradiol (E), progesterone (P) also used modulate CGRP₁₋₃₇. Experiment 1 was in vitro on...
Previous studies have shown that beetroot juice (BJ) decreases systolic blood pressure (SBP) and oxygen demand. This study tests the hypothesis a treatment increases heart rate variability (HRV) measured by average standard deviation of normal-normal electrocardiogram RR intervals (SDNN) low frequency (LF), mainly sympathetic, fast Fourier transform spectral index HRV. The subjects were 13 healthy young adult African-American females. Placebo control orange (OJ) BJ treatments given on...
Orexin/hypocretin-containing neurons in lateral hypothalamus (LH) are implicated the neurobiology of nicotine addiction. However, neuroanatomical relationships between orexin-neurons/nerve fibers and nicotine-activated cells within reward-addiction neurocircuitry is not known. In present study mice, we first used c-Fos immunohistochemistry to identify CNS stimulated by an acute single injection (NIC, 2 mg/kg, IP). Sequential double-labelling was then performed location orexin-containing...
Abstract Neuromodulators regulate higher‐order cognitive processes including learning and memory through modulation of synaptic transmission plasticity. Norepinephrine is a neuromodulator that secreted throughout the brain in response to novelty or increased arousal, which alters neural circuits by increasing modifiability CNS synapses. activates metabotropic receptors, initiating complex intracellular signalling cascades can promote enduring changes strength long‐term potentiation (LTP). In...