Acne vulgaris (AV) is an inflammatory disorder with a possible genetic background. Different cytokines and mediators are involved in its pathogenesis. Our aim was to investigate the interleukin (IL)‐6 572 polymorphism patients AV relation patient sex acne severity. In total, 30 20 healthy controls (HCs) were enrolled. The Global Grading System used assess IL‐6 gene promoter assessed using PCR–restriction fragment length method. There significantly higher association of variants genotypes...

Background. Type 2 diabetes mellitus (T2DM) is a chronic disease with many dramatic complications. It has also been suggested that altered intestinal microbiota leads to increased permeability and mucosal immune response, contributing the development of diabetes. We aimed investigate effect introduction probiotic products on glycemic control inflammatory markers among patients T2DM. Methods. The present work was carried 150 studied were subjected full history taking, clinical examination...

To evaluate resistin level in systemic lupus erythematosus (SLE) patients and to assess the relationship with insulin resistance, disease characteristics, inflammatory markers carotid intima-media thickness (CIMT) as a marker of subclinical atherosclerosis. Thirty adult SLE twenty age sex-matched control were enrolled. All subjected history taking, clinical examination assessment anthropometric measurements. Laboratory investigations included serum resistin, measures highly sensitive...

Association of hepatitis C virus (HCV) with autoimmune phenomena and impaired semen parameters has been previously reported. The aim this study was to investigate the influence HCV infection on development antisperm antibodies (ASAs) in HCV-positive males. conducted 30 HCV-infected individuals healthy control subjects. In both patients groups, liver enzymes reproductive hormones were measured; computer-assisted analysis (CASA) performed; HCV-RNA serum measured IgG IgA ASAs determined. Free...

Background The interest in glutathione-S-transferase (GST) isoenzymes has increased because of their regulatory role the interaction with critical kinases involved controlling stress response, apoptosis, and proliferation. GSTP1 is particular regard to cancer, many tumors are characterized by high expression. Aim work We aimed at evaluating genetic polymorphisms chronic myeloid leukemia (CML) patients. Patients methods genotyped 40 CML patients 30 healthy individuals matched age sex. Results...

The objective of this study was to determine whether plasma resistin levels would be useful in the diagnosis patients with AD and investigate relationships between IL-6, TNF-α, CRP. Ninety five Alzheimer disease(AD) aged 65 years or more 35 sex age matched healthy subjects were included as controls. We excluded participants DM, hypertension, liver renal failure, ischemic heart disease, congestive stroke, thyroid disorders, active infection other inflammatory diseases, chronic use...

Background: The objective is to study the influence of different components metabolic syndrome on clinical behavior and tumor characteristics endometrial cancer cases evaluate if metformin usage affects stage grade cancer.Methods: 60 women attending gynecological oncology clinic at El Shatby Maternity University Hospital, after being diagnosed as carcinoma, were recruited in study. Serum samples collected detect insulin level lipid profile, then allocated into two groups according existence....

Paraoxonase1 (PON1) is a high-density lipoprotein associated A-esterase capable of hydrolysing activated metabolites (oxons) several pesticides as organophosphorous, including chlorpyrifos, diazinon well carbamates. Human PON1 displays polymorphisms in the coding region (Q192R and L55M) promoter 3'-UTR regions. Animal studies showed that high levels protect individuals against acute organophosphatespoisoning. The genotype enzymatic activity together contribute to determining an individual's...

Background AML is a complex and heterogeneous disease. The KRAS gene one of the important genes in pathogenesis acute myeloid leukemia (AML). Mutant RAS can promote oncogenesis via different mechanisms including oncogenic transcription, cell cycle progression, cellular survival, growth, metabolism, migration. Therefore, it to identify genomic landscape AML. aim study variants their association with clinic pathological criteria possible effects on prognosis using NGS.

Introduction Nephrotic syndrome (NS) is one of the most common childhood kidney diseases. Thromboembolic (TE) events are among serious complications NS in children, with a reported prevalence 1.8–5%. Venous thromboembolism (VTE) predominant type. Most cases TE clinically symptomatic, but some may be subclinical, thus, their true incidence underestimated. Studies on onset few and varied, this prompted us to conduct present study.

Different molecular subtypes, including HER2-positive, have been identified in breast cancer. The overexpression of HER2 triggers downstream signaling pathways such as the PI3K/AKT/mTOR pathway. Until recently, trastuzumab has used a single HER2-targeted therapy Egypt. However, resistance to reported. Previous studies demonstrated genetic variants that affect response. However Egypt, few investigated biomarkers p53 might Therefore, we aimed extend genetics workup Her2 + BC include important...

Abstract Background: Chronic inflammation is increasingly recognized as a key factor in many age-related diseases that can lead to acute hospitalizations. Recent research studies have explored the potential of inflammatory biomarkers, such C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), predictors physical cognitive decline older adults. This study investigates association between these markers frailty status elderly population. Materials Methods:...

<h3>Background</h3> Although SLE management has improved markedly in the last few decades, cardiovascular disease (CVD) is still one of most important leading cause death. Subclinical atherosclerosis increased patients with and it not fully explained by traditional risk factors. Evidences suggest that resistin involved pathological processes to CVD including; inflammation, endothelial dysfunction, thrombosis, angiogenesis smooth muscle cell dysfunction. Objectives: determine relation between...