Long non-coding RNAs (lnRNAs) play a pivotal role in various malignancies including AML. Therefore, we decided to study both lnRNA ANRIL and SNHG14 gene expressions patients with AML better understand their risk development, clinical presentation, prognosis.The current prospective included two hundred participants, 100 control subjects. Bone marrow analysis was made all patients, addition expression molecular testing of SNHG14.Both showed high levels bone samples compared non-AML subjects...

Background: MicroRNAs (miRNAs) are short noncoding RNAs of ~21 to 23 nucleotides in length that post-transcriptionally regulate mRNA expression. Highthroughput methodologies have shown deregulated miRNA expression an increasing number human cancers. MiRNA patterns been found distinguish tumors different developmental origin, even better than traditional profiling. Aim: To assess the plasma level microRNA-92a adult acute myeloid leukemia and correlate it with prognostic factors therapeutic...

Background The interest in glutathione-S-transferase (GST) isoenzymes has increased because of their regulatory role the interaction with critical kinases involved controlling stress response, apoptosis, and proliferation. GSTP1 is particular regard to cancer, many tumors are characterized by high expression. Aim work We aimed at evaluating genetic polymorphisms chronic myeloid leukemia (CML) patients. Patients methods genotyped 40 CML patients 30 healthy individuals matched age sex. Results...

Acute myeloid leukemia (AML) is a heterogeneous disorder characterized by clonal expansion of abnormal progenitor cells (blasts) in the bone marrow and peripheral blood. The genetic alterations arising neoplastic clone lead to cascades molecular events that cause proliferation, aberrant differentiation, inhibition normal hematopoiesis malignant cells. MSLN not only expressed solid tumors but also there correlation its expression AML. Recent studies have shown highly 36% acute patients barely...

Enhancer of Zeste Homolog 2 (EZH2) is the catalytic subunit chromatin modifying enzyme polycomb repressive complex (PRC2). As a complex, these proteins selectively silence target genes through trimethylation histone 3 at lysine 27. EZH2 strongly oncogenic. It has been observed in various malignancies which makes it an interesting therapeutic target. Whether functions as tumor suppressor or oncogene acute leukemia not settled. Aim this work: This study aimed determining expression levels gene...

Background: The present work aimed to investigate the expression of CD160/ CD200 in CLL and other mature B-cell neoplasms (MBN) their use as an additional diagnostic tool for differentiating from MBN.
 Materials Methods: Using flow cytometry, we detected CD160 &CD200 on B-cells 30 patients, MBN patients addition 20 controls. CDs160/200 measurements were determined a percentage (≥20% was considered positive) ratio mean fluorescence intensities (MFIR) leukemic cells/controls positive...

Targeting toll-like receptors (TLRs), via TLR agonists, has been implicated in the regulation of immunometabolism. B-chronic lymphocytic leukemia (B-CLL) represents a suitable model for B-cell derived malignancies with shifted metabolic adaptations. Several signaling pathways have found to be critical reprogramming CLL, including mechanistic target rapamycin- hypoxia inducible factor-1α (mTOR- HIF-1α) pathway, main regulator glycolysis. Here, we investigated effect TLR7/8 agonist...

Abstract Background Bloodstream infections (BSIs) in neutropenic patients significantly contribute to morbidity and mortality. The rapid identification determination of antimicrobial susceptibility pathogens causing BSIs can help early initiation targeted therapy allow de-escalation unnecessary empirical antimicrobials. Aim This study evaluated the rapidity accuracy gram-stained smear from blood culture bottles direct VITEK 2 identify determine assessed effect these tests on modification...

Background: Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy that has highly variable clinical course. Genomic features as zeta-chain-associated protein kinase 70 (ZAP70) expression and CD38 provide further differentiation of disease prognosis. Extensive studies have confirmed the oncogenic activities IL-9 in lymphoma. The aim current study was to investigate contribution pathogenesis CLL its correlation other prognostic parameters.Methods: This conducted on 80 patients at...

BACKGROUND: Acute monocytic leukemia (AML) is a common hematological malignancy with different subtypes. AML involvement (AML M5) the most frequent subtype among adults. Many genetic and epigenetic abnormalities were described in adult AML. Methylation status studied for classification, as prognostic marker even therapeutic implications. p15 E-cadherin promotor region methylation are frequently implicated kinds of nonhematological malignancies.AIM OF THE WORK: The aim to detect group...

From this study, we concluded that: 1.Expression of HOTAIR is upregulated in newly diagnosed adult AML patients and it can be used as a diagnostic marker these patients.2. expression not associated with poor outcome or prognosis our study.3.There was no significant correlation between lncRNA CD117(c-kit) acute myeloid leukemia.4.There group very high which need further assessment higher number patients.

Patients with a higher PRMT1 gene expression level were significantly less likely to achieve complete remission after standard induction chemotherapy than those lower level.FLT3 mutation positivity had no significant correlation levels.The presented study was conducted on 40 newly diagnosed AML patients in Alexandria University Main Hospital, Internal Medicine Department, Haematology Unit, from the period of December 2020 August 2021.All our tested for bone marrow aspirate samples at time...

ILT3 is a highly specific and sensitive biomarker that used as diagnostic tool to distinguish AML with monocytic differentiation from other types of AML.This the basis for new methods diagnosis, monitoring, treatment expressing ILT3. PATIENTS: The current study was conducted on110 patients:Group I: Fifty-five adult patients diagnosed were randomly recruited hematology unit Alexandria main university hospital Medical Research Institute.Group II: Thirty-five without differentiation.Group III:...