A5026203518- Myasthenia Gravis and Thymoma
- Peripheral Neuropathies and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Physics and Engineering Research Articles
- Monoclonal and Polyclonal Antibodies Research
- Erythrocyte Function and Pathophysiology
- Single-cell and spatial transcriptomics
- Glioma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Tryptophan and brain disorders
- Engineering and Materials Science Studies
- Stress Responses and Cortisol
- Immune Cell Function and Interaction
- Ion channel regulation and function
- Advanced Combustion Engine Technologies
- Chronic Lymphocytic Leukemia Research
- Electric and Hybrid Vehicle Technologies
- Acute Lymphoblastic Leukemia research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer, Lipids, and Metabolism
- Immunodeficiency and Autoimmune Disorders
- Glycosylation and Glycoproteins Research
- Ferroptosis and cancer prognosis
- Cancer Treatment and Pharmacology
- Neurogenesis and neuroplasticity mechanisms
Heidelberg Pharma (Germany)
2023
Charité - Universitätsmedizin Berlin
2015-2022
German Rheumatism Research Centre
2019
Humboldt-Universität zu Berlin
2019
Freie Universität Berlin
2019
Mann+Hummel (Germany)
2014-2017
Max Delbrück Center
2014-2015
University Hospital Magdeburg
2002
Klinikum Magdeburg
2002
Malignant glioma belong to the most aggressive neoplasms in humans with no successful treatment available. Patients suffering from glioblastoma multiforme (GBM), highest-grade glioma, have an average survival time of only around one year after diagnosis. Both microglia and peripheral macrophages/monocytes accumulate within but fail exert effective anti-tumor activity even support tumor growth. Here we use microarray analysis compare expression profiles glioma-associated microglia/macrophages...
The role of Th17 cells in the pathogenesis autoantibody-mediated diseases is unclear. Here, we assessed contribution to experimental autoimmune myasthenia gravis (EAMG), which induced by repetitive immunizations with Torpedo californica acetylcholine receptor (tAChR). We show that a significant fraction tAChR-specific CD4(+) T producing IL-17. IL-17(ko) mice developed fewer or no EAMG symptoms, although frequencies secreting IL-2, IFN-γ, IL-21, and percentage FoxP3(+) Treg were similar WT...
Abstract Antibody‐mediated diseases affect more than 10% of the human population. For most, no cure is available, particularly when pathogenic antibodies are secreted by long‐lived plasma cells resistant to conventional immunosuppressive therapies. Current therapeutic approaches target not only that secrete antibodies, but also those providing protective antibodies. Here, in a murine model bearing secreting anti‐OVA and ‐chicken gamma globulin (CGG) we describe first‐time use an...
Abstract Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness and fatigue in the presence of circulating antibodies against components neuromuscular junction. Most patients have a good prognosis, but some are refractory to standard‐of‐care immunosuppressive treatment suffer from recurrent myasthenic crises. Functional sphingosine‐1‐phosphate (S1P) antagonists like fingolimod siponimod (BAF312) successfully used for multiple sclerosis, was shown prevent development...
<h3>Background:</h3> Antibody-mediated diseases like allergies and chronic-inflammatory autoimmune affect more than 10% of the human population, for most, no cure is available. This particularly true when pathogenic antibodies are secreted by long-lived plasma cells generated early in pathogenesis, which refractory to conventional therapies. Therapeutic concepts generic ablation currently being tested clinical trials. These target both secreting those providing protective antibodies, i.e.,...
Abstract Background: Amatoxin-based antibody drug conjugates (so called ATAC®s) constitute a new class of antibody-drug (ADCs) which utilize amanitin as toxic payload. Amanitin binds to the RNA pol II and thereby efficiently inhibits cellular transcription. In current study, in vitro vivo data an ATAC® targeting GCC (guanylyl cyclase C) are presented. is cell surface receptor expressed &gt;95% colorectal cancer, approximately 65% esophageal, gastric, pancreatic tumors. healthy conditions...
Accelerated postsynaptic remodelling and disturbance of neuromuscular transmission are common features autoimmune neurodegenerative diseases. Homer protein isoform expression, crosslinking activity subcellular localisation studied in mouse hind limb muscles an experimentally induced model Myasthenia Gravis (EAMG) correlated to motor end plate integrity. Soleus (SOL), extensor digitorum longus (EDL) gastrocnemius (GAS) skeletal investigated. nAChR membrane clusters were monitor junction (NMJ)...
OBJECTIVE: Glioma, such as anaplastic astrocytoma and glioblastoma multiforme, belong to the most aggressive neoplasms in humans. Microglia peripheral macrophages are attracted towards glioma their abundance positively correlates with malignancy, invasiveness tumor grade. Glioma exhibit an immunosuppressive milieu, glioma—associated microglia/macrophages polarized M2—like anti— inflammatory phenotype actively support growth, e.g. via release of immune—suppressive cytokines, factors that...
<h3>Background and objectives</h3> Long-lived plasma cells (LLPCs) producing pathogenic antibodies are an important factor in autoimmune diseases maintenance relapse. The therapeutic options available so far for targeting these (e.g. autologous stem cell transplantation, bortezomib) have the major disadvantage of eliminating protective humoral immunity with obvious caveats regarding a higher risk infection. Therefore development new tools selective depletion LLPCs secreting would be great...