A5021719854- RNA Interference and Gene Delivery
- Diabetes Treatment and Management
- Advanced biosensing and bioanalysis techniques
- Marine animal studies overview
- Cystic Fibrosis Research Advances
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Metabolism, Diabetes, and Cancer
- Asthma and respiratory diseases
- Pharmacology and Obesity Treatment
- Polar Research and Ecology
- Virus-based gene therapy research
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Viral gastroenteritis research and epidemiology
- Carcinogens and Genotoxicity Assessment
- Inhalation and Respiratory Drug Delivery
- DNA and Nucleic Acid Chemistry
- COVID-19 and Mental Health
- Olfactory and Sensory Function Studies
- Respiratory viral infections research
- Adenosine and Purinergic Signaling
- Ion channel regulation and function
- Outdoor and Experiential Education
Case Western Reserve University
1999-2024
University School
2000-2024
Knowledge Integration (United Kingdom)
2024
Birmingham Children's Hospital
2014
John Radcliffe Hospital
2014
Northampton General Hospital
2014
University of Michigan
2006
University Hospitals of Cleveland
2005
University of Cambridge
1994-1999
Jacksonville College
1999
This cohort study assesses the association of COVID-19 with new-onset type 1 diabetes among pediatric patients.
Abstract Alcohol use disorders are among the top causes of global burden disease, yet therapeutic interventions limited. Reduced desire to drink in patients treated with semaglutide has raised interest regarding its potential benefits for alcohol disorders. In this retrospective cohort study electronic health records 83,825 obesity, we show that compared other anti-obesity medications is associated a 50%-56% lower risk both incidence and recurrence disorder 12-month follow-up period....
Cannabis is the most frequently used illicit drug in United States with more than 45 million users of whom one-third suffer from a cannabis use disorder (CUD). Despite its high prevalence, there are currently no FDA-approved medications for CUD. Patients treated semaglutide, glucagon-like peptide-1 receptor agonist (GLP-1RA) approved treating type 2 diabetes (T2D) and weight management have reported reduced desire to drink smoke. Preclinical studies shown that semaglutide decreased nicotine...
Abstract INTRODUCTION Emerging preclinical evidence suggests that semaglutide, a glucagon‐like peptide receptor agonist (GLP‐1RA) for type 2 diabetes mellitus (T2DM) and obesity, protects against neurodegeneration neuroinflammation. However, real‐world its ability to protect Alzheimer's disease (AD) is lacking. METHODS We conducted emulation target trials based on nationwide database of electronic health records (EHRs) 116 million US patients. Seven were emulated among 1,094,761 eligible...
Abstract Background Gabapentin and pregabalin are commonly prescribed medications to treat pain in patients with diabetic neuropathy. can cause fluid retention, which is hypothesized be associated cardiovascular diseases. However, whether long-term use of gabapentin adverse diseases remains unknown. This study aims examine the association between use, several events. Methods retrospective cohort used propensity score matching within patient electronic health records (EHRs) from a multicenter...
Reports of reduced desire to smoke in patients treated with semaglutide, a glucagon-like peptide receptor agonist (GLP-1RA) medication for type 2 diabetes mellitus (T2DM) and obesity, have raised interest about its potential benefit tobacco use disorders (TUDs).
DNA can be compacted using polyethylene glycol-substituted poly-l-lysine into discrete unimolecular (with respect to DNA) nanoparticles with minor diameter <20 nm that are stable in normal saline for at least 23 months 4°C. We compared the activity of firefly luciferase lungs C57BL/6 mice received 100 μg plasmid 25 μl (shown optimal dose) via intratracheal or intranasal instillation levels animals given naked untreated mice. Mice dosed had peak lung 2 days postinstillation, which declined...
C105Y, a synthetic peptide (CSIPPEVKFNKPFVYLI) based on the amino acid sequence corresponding to residues 359-374 of alpha1-antitrypsin, enhances gene expression from DNA nanoparticles. To investigate how this enhancement occurs, C105Y was fluorescently labeled study its uptake and intracellular trafficking. When human hepatoma cells (HuH7) were incubated with for as little 3 min, displayed nuclear cytoplasmic staining enrichment fluorescent signal in nucleus nucleolus. Uptake nucleolar...
Importance In adults, diagnoses of new-onset type 2 diabetes (T2D) have increased following diagnosis with COVID-19, but whether this occurs in children is unclear. Objective To determine risk incident T2D during the 6 months after SARS-CoV-2 infection among children. Design, Setting, and Participants This retrospective cohort study used electronic health records from TriNetX analytics platforms between January 1, 2020, December 31, 2022. Pediatric patients aged 10 to 19 years without...
Nanoparticles containing DNA compacted with poly-l-lysine modified on an N-terminal cysteine polyethylene glycol can effectively transfect cells of the airway epithelium when applied by luminal route. To evaluate toxicity these nanoparticles, we administered 10 and 100 μg into nanoparticles suspended in normal saline intranasal route to mice determined pulmonary systemic responses this challenge, compared administration alone, some experiments, naked DNA, Escherichia coli genomic or...
Over 90% of untreated CFTR S489X homozygous (CF) mutant mice reportedly die intestinal obstruction by 40 days age, significantly limiting their usefulness as a model for the human disease. Because period highest mortality is during week after weaning, we hypothesized that providing low-residue liquid diet would improve survival and growth. When 99 CF survived to 10 age were fed Peptamen (Clintec Nutrition), an elemental diet, housed on corn-cob bedding, 88% them maturity (50 days). The...
Objectives/Goals: Opioid use disorder (OUD) at delivery increased between 1999 and 2014. Clinical guidelines include medication for OUD (MOUD) pregnant women with is associated better fetal outcomes. Few large studies have compared prenatal MOUD outcomes to no MOUD. We evaluated the association of documented prescription during pregnancy maternal Methods/Study Population: utilized aggregated electronic health records using TriNetX platform conduct a retrospective cohort study females, aged...
Abstract The Centers for Disease Control and Prevention announced in January 2023 a potential connection between administration of the Pfizer novel coronavirus disease-2019 (COVID-19) bivalent vaccine booster ischemic stroke (IS). A retrospective cohort study was conducted to compare hazard IS patients aged 65 years over administered versus those Pfizer/Moderna monovalent or Moderna boosters. De-identified patient electronic health data were collected from TriNetX, cloud-based analytics...
Abstract COVID-19 is associated with increased risks for mood or anxiety disorders, but it remains uncertain how the association evolves over time which patient groups are most affected. We conducted a retrospective cohort study using nationwide database of electronic health records to determine risk depressive disorder diagnoses after SARS-CoV-2 infection by 3-month blocks from January 2020 April 2022. The population comprised 822,756 patients (51.8% female; mean age 42.8 years) and...
Beginning in October 2021 the USA and elsewhere, cases of severe paediatric hepatitis unknown aetiology were identified young children. While adenovirus adenovirus-associated virus have emerged as leading aetiological suspects, we attempted to investigate a potential role for SARS-CoV-2 development subsequent liver abnormalities. We conducted study using retrospective cohorts deidentified, aggregated data from electronic health records over 100 million patients contributed by US healthcare...
Healthy adult volunteers (n = 122), who denied personal history of lung disease or family cystic fibrosis asthma, took no interfering medications, and had forced expiratory volume in 1 s greater than equal to 80% predicted, underwent methacholine challenge pupillary reactivity testing. Pupil diameter measured dark light test conditions declined with age (Pearson's r -0.54 -0.36). Pupillary alpha-adrenergic responsiveness (expressed as the concentration phenylephrine required dilate pupil mm)...