A5101462377- Biochemical and Molecular Research
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Antifungal resistance and susceptibility
- Clostridium difficile and Clostridium perfringens research
- Animal health and immunology
- Gastrointestinal motility and disorders
- Tryptophan and brain disorders
- Medical and Biological Ozone Research
- Air Quality and Health Impacts
- Protein Kinase Regulation and GTPase Signaling
- Pancreatic function and diabetes
- Parasitic Diseases Research and Treatment
- Medicinal Plants and Bioactive Compounds
- Pediatric health and respiratory diseases
- Hernia repair and management
- Fungal Infections and Studies
- Intestinal and Peritoneal Adhesions
- Cardiac Fibrosis and Remodeling
- Psychological and Temporal Perspectives Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver physiology and pathology
- Alzheimer's disease research and treatments
- Probiotics and Fermented Foods
- Dietary Effects on Health
Guangzhou University of Chinese Medicine
2022-2024
National Institutes of Health
2023-2024
National Institute of Diabetes and Digestive and Kidney Diseases
2023-2024
Jiangsu Normal University
2024
Luoyang Orthopedic-Traumatological Hospital of Henan Province
2023
Luye Pharma (China)
2016
Nanjing University
2014
Nanjing General Hospital of Nanjing Military Command
2014
The University of Texas Southwestern Medical Center
2013
Southwestern Medical Center
2013
Alzheimer's disease (AD) is a progressive, neurodegenerative that may involve inflammatory responses in the central nervous system (CNS). Our objective was to determine whether patients with amnestic mild cognitive impairment (aMCI), preclinical stage of AD, have characteristics similar multiple sclerosis (MS), known CNS disease. The frequency lymphocytes and levels pro-inflammatory cytokines cerebrospinal fluid aMCI comparable MS or at high risk develop MS. Thus, brain inflammation occurs...
Although low temperature and air pollution exposures have been associated with the risk of anxiety, their combined effects remain unclear.To investigate independent interactive on anxiety.Using a case-crossover study design, authors collected data from 101,636 outpatient visits due to anxiety in three subtropical Chinese cities during cold season (November April 2013 through 2018), then built conditional logistic regression models based individual exposure assessments [temperature, relative...
HIV-1 infection depends on the integration of viral DNA into host chromatin. Integration is mediated by enzyme integrase and blocked strand transfer inhibitors (INSTIs), first-line antiretroviral therapeutics widely used in clinic. Resistance to even best INSTIs a problem, mechanisms resistance are poorly understood. Here, we analyze combinations mutations E138K, G140A/S, Q148H/K/R, which confer INSTIs. The investigational drug 4d more effectively inhibited mutants compared with approved...
Objectives: To assess HIV and syphilis infections among men who have sex with use the internet (MSMUI) their risk behaviors. Methods: In 2007, 429 MSMUI were recruited via in Beijing Urumqi, China. A questionnaire was administered, a blood specimen collected tested for syphilis. Results: Median age of participants 25 years. number lifetime sexual partners 10. 90.7% ever had cyber friend. Rates condom last oral, insertive, receptive anal 9.1%, 66.3%, 60.4%, respectively. Infection rates HIV,...
Diabetic nephropathy (DN) is a major contributor to end-stage renal failure, and lacking effective treatment options. Shengqing Jiangzhuo capsule (SQJZJN), traditional Chinese medicine prescription with known efficacy in chronic kidney disease, has not been thoroughly investigated for its potential DN protection.
The incidence of Clostridium difficile infection has increased in Western world the past 10 years, similar rates are also reported developing countries such as China. Current antibiotics treatments have recurrence between 15% and 30%. IgY antibodies against toxin A C. could protect animal models from challenge lethal dose spores. However, is sensitive to low pH environment stomach proteinases intestine. objective this study was prepare colonic-specific delivery system antigen-specific block...
To explore lumbar plexus nerve block combined with general anesthesia in elderly patients undergoing hip operation could improve analgesia effect, reduce consumption of analgesics, prevent inflammatory reaction, and avoid postoperative delirium(POD).Totally 200 underwent fracture surgery from February 2020 to September 2021 were selected divided into observation group control according different methods. There 97 including 66 males 33 females; aged (70.23±6.60) years old;body mass index...
Retroviral integration is mediated by intasome nucleoprotein complexes wherein a pair of viral DNA ends are bridged together multimer integrase (IN). Atomic-resolution structures HIV-1 intasomes provide detailed insights into the mechanism and inhibition clinical IN inhibitors. However, previously described highly heterogeneous have tendency to form stacks, which limiting factor in determining high-resolution cryo-EM maps. We assembled presence excess C-terminal domain protein, was readily...
Integrase (IN) performs dual essential roles during HIV-1 replication. During ingress, IN functions within an oligomeric intasome assembly to catalyze viral DNA integration into host chromatin. late stages of infection, tetrameric binds RNA and orchestrates the condensation ribonucleoprotein complexes capsid core. The molecular architectures assemblies that mediate these distinct events remain incompletely characterized. Furthermore, tetramer is important antiviral target for allosteric...
The extensive use of traditional chemical pesticides can have an impact on human health. On the other hand, biopesticides advantages having fewer side effects body and being generally more beneficial to In order reduce pesticide thiabendazole, cinnamaldehyde, active plant extract, is compounded with thiabendazole form a new type low - toxicity biopesticide fungicide preservative, its fungicidal preservative are studied. A large number antibacterial experiments show that when ratio...