A5087446215- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Pneumonia and Respiratory Infections
- Data-Driven Disease Surveillance
- Glioma Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
- MicroRNA in disease regulation
- HIV/AIDS drug development and treatment
- Healthcare Systems and Reforms
- Drug-Induced Hepatotoxicity and Protection
- Cancer Cells and Metastasis
- Neurogenesis and neuroplasticity mechanisms
- Medical Research and Treatments
- Delphi Technique in Research
- Liver Disease Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- TGF-β signaling in diseases
- Chronic Disease Management Strategies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mental Health Treatment and Access
- Kawasaki Disease and Coronary Complications
- Pharmacological Effects of Natural Compounds
- Forecasting Techniques and Applications
Shanghai Sunshine Rehabilitation Center
2022-2024
Affiliated Hospital of Nantong University
2023-2024
Nantong University
2023-2024
Shanghai University
2023-2024
Jiangsu Normal University
2024
Shanghai East Hospital
2024
Tongji University
2006-2023
Shanghai Tenth People's Hospital
2017-2022
Heilongjiang Center for Tuberculosis Control and Prevention
2011-2022
Chongqing Jiulongpo People's Hospital
2014-2022
Aim The aim of this article is to characterize the glucometabolic state patients with coronary artery disease (CAD) in China. Methods and results This multicentre study recruited 3513 hospitalized for CAD, whom 35.1% were admissions acute CAD 64.9% elective CAD. At entry, 1153 had known type 2 diabetes 97 newly diagnosed [fasting plasma glucose level (FPG) ≥7.0 mmol/L]. Oral tolerance tests (OGTTs) performed remaining revealed that 26.9% 37.3% impaired regulation (IGR). prevalence abnormal...
Background Anti-tuberculosis drug induced liver injury (ATLI) is emerging as a significant threat to tuberculosis control in China, though limited data available about the burden of ATLI at population level. This study aimed estimate incidence ATLI, better understand its clinical features, and evaluate impact on anti-tuberculosis (TB) treatment China. Methodology/Principal Findings In population-based prospective study, we monitored 4,304 TB patients receiving directly observed strategy...
Background More than 1 million tuberculosis (TB) patients are receiving directly observed treatment strategy (DOTS) therapy in China every year. As to the profile of adverse drug reactions (ADRs) due DOTS therapy, no consensus has been reached. There is report regarding ADRs with a large Chinese TB population. This study aimed determine incidence and prognosis evaluate their impact on anti-TB China. Methods A prospective population-based cohort was performed during 2007–2008. Sputum smear...
China is a country with high burden of pulmonary tuberculosis (PTB). Chongqing in the southwest China, where notification rate PTB ranks tenth China. This study analyzed temporal and spatial distribution characteristics order to improve TB control measures.A spatial-temporal analysis has been performed based on data from 2011 2018, which was extracted National Surveillance System. The effect measured by variation trend pathogenic positive total rate. Time series, autonomic correlation...
This paper evaluated the treatment adherence for multidrug-resistant tuberculosis (MDR-TB) and MDR-TB case management (MTCM) in Chongqing, China order to identify factors associated with poor management.Surveys 132 patients six in-depth interviews health care workers (HCWs) from primary centers (PHC), doctors designated hospitals were conducted. Surveys collected demographic socio-economic characteristics, as well management. In-depth gathered information on experience behaviors.Patient...
<h3>Objective</h3> To assess the association between fasting plasma glucose (FPG) levels on admission and mortality in older patients with acute myocardial infarction (AMI), compare effects of FPG outcomes context contemporary treatments, including drug treatment, percutaneous coronary intervention artery bypass grafting. <h3>Methods</h3> From April 2004 to October 2006, 1854 (age ≥65 years) AMI were enrolled Beijing Elderly Acute Myocardial Infarction Study (BEAMIS) consecutively. Patients...
Health promotion for prevention and control of Tuberculosis (TB) is implemented worldwide because its importance, but few reports have evaluated impact on behavior due to a lack standard outcome indicators. The objective this study was establish framework behavioral indicators evaluation TB health among suspects patients. A two-round modified Delphi method involving sixteen experts used targeted at Sixteen seventeen invited in (authority score 0.91 1.0 scale) participated round 1 survey. All...
Neural stem cells (NSCs) can generate new neurons to repair brain injury and central nervous system disease by promoting neural regeneration. MicroRNAs (miRNAs) involve in development, damage, neurological diseases repair. Recent reports show that several miRNAs express NSCs are important neurogenesis. Neurites play a key role NSC-related However, the mechanism of NSC neurite generation is rarely studied. We surprisingly noticed neurites increased after bone morphogenetic protein (BMP)...
Multi-drug resistant tuberculosis (MDR-TB) represents a threat to health and development in countries with high TB burden. China's MDR-TB prevalence rate of 6.8% is the highest world. Interventions remove barriers against effective control, prevention are urgently needed country. This paper reports cross-sectional questionnaire survey 513 pulmonary (PTB) patients, qualitative interviews 10 healthcare workers (HCWs), 15 PTB patients. The objective was assess control by elucidating...
The failure of current Standard Short-Course Chemotherapy (SCC) in new and previously treated cases with tuberculosis (TB) was mainly due to drug resistance development. But little is known on the characteristics acquired resistant TB during SCC its correlation failure. objective study explore traits emergence evaluate their impacts treatment outcomes. A prospective observational performed newly admitted smear positive pulmonary (PTB) without pretreatment under China's National Control...
Objective To investigate the extent and associations of patient/diagnostic delay other potential factors with catastrophic health expenditure (CHE) for tuberculosis (TB) care in Chongqing municipality, China. Design A cross-sectional study. Setting Four counties Participants total 1199 patients active pulmonary TB beyond 16 years without mental disorders were consecutively recruited four counties’ designated medical institutions. Outcome measures The incidence intensity CHE described....
We aimed to explore the effectiveness of preventive usage hepatoprotectors in patients with tuberculosis (TB) receiving anti-TB treatment.With stratified cluster sampling strategy, a prospective cohort 4488 sputum smears positive pulmonary TB was established from 52 counties four regions China. During treatment, prescriptions were documented detail, and liver enzymes routinely monitored. Anti-TB drug-induced injury (ATLI) assessed based on following criteria American Thoracic Society. The...
Abstract Chongqing is a southwest city of China with high tuberculosis (TB) burden. An observational retrospective study has been performed based on routine TB surveillance data in from 1992 to 2015. The notification rate declined 70.8 cases per 100,000 population the peak 106 2005. over-65 years become highest among all-ages since 2010. average proportion farmers all notified 2008 2015 was 62.5%, and occupations 2011. showed regional disparity Chongqing. Despite improvement achieved 1992,...
Stem cell-based therapies have been used for repairing damaged brain tissue and helping functional recovery after injury. Aberrance neurogenesis is related with injury, multipotential neural stem cells from human embryonic (hES) provide a great promise cell replacement therapies. Optimized protocols differentiation are necessary to produce (hNSCs) therapy. However, the qualified procedure scarce detailed features of hNSCs originated hES still unclear. In this study, we developed method...
Objective Tuberculosis (TB) treatment management services (TTMSs) are crucial for improving patient adherence. Under the TB integrated control model in China, healthcare workers (HCWs) primary (PHC) sectors responsible TTMS delivery. This mixed-method study aimed to explore status of and barriers delivery faced by HCWs PHC from health organisational perspectives. Design We completed a questionnaire survey 261 (TB HCWs) 459 patients with sector conducted 20 semistructured interviews leaders,...
Malignant Glioma is characterized by strong self-renewal potential and immature differentiation potential. The main reason that malignant glioma holds key cluster cells, stem cells (GSCs). GSCs contribute to tumorigenesis, tumor progression, recurrence, treatment resistance. Interferon-beta (IFN-β) well known for its anti-proliferative efficacy in diverse cancers. IFN-β also displayed potent antitumor effects glioma. affect both Neural (NSCs) the of gliomas. However, functional comparison,...
China is one of the top 30 countries with high multidrug-resistant tuberculosis (MDR-TB) and rifampin-resistant (RR-TB) burden. Chongqing a southwest city large rural population. A retrospective observational study has been performed based on routine (TB) surveillance data in from 2010 to 2017. The MDR/RR-TB notification rate increased 0.03 cases per 100,000 population 2.1 extensively drug-resistant TB (XDR-TB) 0.09 There was decreasing detection gap between number notified estimate new...
Although TB health promotion directed at policy makers and healthcare workers (HCWs) is considered important to tuberculosis (TB) control, no indicators currently assess the impact of such promotional activities. This article second in a series papers that seek establish framework behavioral for outcome evaluation promotion, using Delphi method. In first article, we sought among suspects patients. The objective this present an indicator can be used outcomes HCWs. A two-round, modified method...
Abstract Background Data on effect of regular liver function monitoring during anti-TB treatment is limited in China. This study aimed to evaluate the effects scheduled identification asymptomatic damage and outcomes treatment. Methods A retrospective analysis was performed based a national-level cohort study. total 273 patients developing dysfunction were divided into two groups, 111 who diagnosed through test within months after initiation formed group, others due symptoms passive...
Abstract Background Tuberculosis (TB) is one of the top 10 causes death in world. Since Directly Observed Therapy (DOT) as a core strategy for global TB control are not applicable to all types patients, and self-management patients (SMTP) patient-centered supervision type supplement DOT can improve case management. However, factors related SMTP complex need more study. This study aimed at identifying determinants examining direct/indirect effects these determinants. Methods The purposive...
Abstract Background China is one of 30 countries with a high tuberculosis (TB) burden, and poor adherence to TB treatment the biggest challenges for control. We aimed explore barriers facilitators among drug-sensitive (DS-TB) patients under “Integrated model” in Western China, provide evidence-based control regimens DS-TB improve behaviours. Methods Both qualitative quantitative research methods were used factors associated self-reported (SRA) Questionnaire surveys in-depth interviews...