Quercetin, a naturally occurring dietary flavonoid, is well known to ameliorate chronic diseases and aging processes in humans, its antiviral properties have been investigated numerous studies. In silico vitro studies demonstrated that quercetin can interfere with various stages of the coronavirus entry replication cycle such as PLpro, 3CLpro, NTPase/helicase. Due pleiotropic activities lack systemic toxicity, derivatives may represent target compounds be tested future clinical trials enrich...

An approach based on the difference (Delta(ab) = delta(a) - delta(b)) between 1H NMR chemical shifts (delta(a), of geminal protons glycosyloxy methylene (H2-26) <0.48 for 25R; Delta(ab) >0.57 25S) is proposed ascertaining 25R/25S orientation 27-methyl group furostane-type steroidal saponins. These studies suggested 25R-orientation 27-Me furostanol glycosides isolated by Wu et al. from Tribulus terrestris.

It is debated whether teenage pregnancy associated with an adverse reproductive outcome. This study assessed the outcomes in Nepal, a developing setting.A hospital based retrospective cohort of 4,101 deliveries to compare between and non-teenage pregnancies.Pregnancy teenagers was significantly increased risk (P<0.05) delivery very moderately preterm births Low Birth Weight babies. There no significant difference having small for gestational age babies, low APGAR score at birth 1 min 5 min,...

Hesperidin and hesperetin are flavonoids that abundantly present as constituents of citrus fruits. These compounds have attracted attention several computational methods, mostly docking studies, shown hesperidin may bind to multiple regions severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (spike protein, angiotensin-converting enzyme 2, proteases). has a low binding energy, both with the SARS-CoV-2 “spike” protein responsible for internalization, also “PL pro ” “M transforming...

Abstract In the current investigation, enhancement in mechanical properties, thermal stability, and decrement moisture absorption capabilities of polyvinyl alcohol was observed by cross‐linking it with different weight percentages (wt. %) fumaric acid reinforcing them along sulfuric acid‐modified graphite particles. The effects altering duration wt. % were investigated resulting composite using Taguchi L16 experimental design method. As this contemporary era rapid industrial expansion fierce...

Abstract The 13 C NMR chemical shifts of 126 Steroidal sapogenins published between 1983 and 1993 are listed critical spectral features advances made in the characterization these compounds discussed as a guide for identification parent skeleton determination substitution patterns. spectroscopic methods applicable to deduce complete structure oligosaccharide moiety its linkage sapogenin residue also presented elucidate steroidal saponins.

Abstract 13 C NMR shielding data for about 300 compounds are tabulated, and critical spectral features discussed as a guide to the use of technique in structure elucidation stereochemical allocations lignan, neolignan their derivatives. Unanalysed reported have been analysed and, wherever necessary, signal assignments revised on basis more recent evidence obtain consistency throughout series.

To reduce the hydrophilicity of polyvinyl alcohol (PVA), various methods are employed. Acid cross-linking is one technique, but it decreases polymer's strength. address this, different reinforcements utilized to enhance strength while mitigating side effects acid cross-linking. The present research intends improve physical, mechanical, and thermal properties PVA by with fumaric reinforcing modified graphite particles. particles were prepared through oxidative acidic treatment added in weight...

Abstract Polyvinyl alcohol (PVA) is a widely used polymer that biocompatible, nontoxic, and water‐soluble due to the presence of hydroxyl groups in its domain. This study aims investigate effects fumaric acid (FA) cross‐linking thermal (TC) on PVA's mechanical properties. When FA mixed with PVA, it was found chemical reaction OH PVA are condensing carboxylic units yield new ester linkages water as by‐product, which further results reduction absorption capacity. Quantitatively, addition 8...

Various computational studies, including in silico ones, have identified several existing compounds that could serve as effective inhibitors of the SARS-CoV-2 main protease (M pro ), and thus preventing replication virus. Among these, rutin has been a potential hit, having prominent binding affinity to Moreover, its presence traditional antiviral medicines prescribed China infected patients with mild moderate symptoms COVID-19 justify promise repurposed bioactive secondary metabolite against...

Abstract A method based on the differences among 1 H NMR chemical shifts of geminal protons ring‐F methylene resonances (H 2 ‐23, ‐24 and ‐26) is proposed for ascertaining 25 R /25 S stereochemistry unsubstituted spirostane‐type steroidal sapogenins saponins. Copyright © 2003 John Wiley &amp; Sons, Ltd.

Abstract The assignments of the 13 C NMR shift values dihydrobenzofuranoid lignans cedrusin and dihydrodehydrodiconiferyl alcohol, their respective 4‐ O ‐β‐ D ‐glucosides acetates have been made. furanoid stereochemistry in 8,3′‐lignans could be deduced from comparative data.