A5012365321- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- Traumatic Brain Injury Research
- Autism Spectrum Disorder Research
- Anesthesia and Neurotoxicity Research
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Cardiac Arrest and Resuscitation
- Liver Disease Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Sirtuins and Resveratrol in Medicine
- Glutathione Transferases and Polymorphisms
- Urinary Tract Infections Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Exercise and Physiological Responses
- Cell death mechanisms and regulation
- Fatty Acid Research and Health
- Neonatal Health and Biochemistry
- Cancer Mechanisms and Therapy
- Polyamine Metabolism and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Paleopathology and ancient diseases
Bam University of Medical Sciences
2015-2025
Kerman University of Medical Sciences
2020-2024
Rafsanjan University of Medical Sciences
2014
Traumatic brain injury (TBI) causes progressive dysfunction that induces biochemical and metabolic changes lead to cell death. Nevertheless, there is no definitive FDA-approved therapy for TBI treatment. Our previous immunohistochemical results indicated the cost-effective natural Iranian medicine, Satureja khuzistanica Jamzad essential oil (SKEO), which consists of 94.16% carvacrol (CAR), has beneficial effects such as reducing neuronal death inflammatory markers, well activating astrocytes...
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by persistent social communication deficits and restricted, repetitive behaviours, with significant overlap in anxiety‐related symptoms. Both genetic environmental factors contribute to the development of ASD, early‐life stressors, such as maternal separation (MS), exposure neurotoxic agents, like valproic acid (VPA), being key contributors. This study investigates combined impact deprivation (MD)...
ABSTRACT Objective Evidence suggests that exercise timing is crucial in reducing the impact of traumatic brain injury (TBI). The present study explores effects delayed and early on damage, cognitive dysfunction, anxiety behavior using an experimental TBI model. Methods We randomly assigned 36 male rats to six groups: control (sham, TBI), treadmill (24hA, 1‐month 24 h after 1WA (1‐month 1 week 1MB before 1MBA TBI). Results caused significant impairments behaviors, as well increased edema ( p...
Studies have confirmed the salutary effects of progesterone (P4) on traumatic brain injury (TBI). This study investigated beneficial P4 via its receptors TBI, and also whether (PRs) can modulate TBI through PI3K/Akt pathway.Marmarou method was utilized to induce diffuse in ovariectomized rats. (1.7 mg/kg) or vehicle (oil) administered 30 min after induction. Moreover, RU486 (PR antagonist) (DMSO) were injected before induction injection. Brain Evans blue content, water content (WC), various...
Protective effects of estrogen (E2) on traumatic brain injury (TBI) have been determined. In this study, the hepatoprotective E2 after TBI through its receptors and oxidative stress regulation evaluated. Diffuse induced by Marmarou method in male rats. G15, PHTPP, MPP, ICI182–780 as selective antagonists were injected before TBI. The results indicated that induces a significant increase liver enzymes [Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Alanine (ALT), Glutamyl...
Due to the crucial role of polyamines during fetal growth and development, we aimed determine effect prenatal administration agmatine, an endogenous active metabolite arginine, a nutritional supplement, on autistic-like behaviors, oxidative-anti-oxidative profile, histopathological changes prefrontal cortex (PFC) CA1 area hippocampus in valproic acid (VPA) model autism male rats.
The contribution of classic progesterone receptors (PR) in interceding the neuroprotective efficacy (P4) on prevention brain edema and long-time behavioral disturbances was assessed traumatic injury (TBI).Female Wistar rats were ovariectomized apportioned into 6 groups: sham, TBI, oil, P4, vehicle, RU486. P4 or oil injected following TBI. antagonist PR (RU486) DMSO administered before destruction blood-brain barrier (BBB) determined. Intracranial pressure (ICP), cerebral perfusion (CPP),...
The benefits of exercise in TBI have been proven. However, the time-dependent effects initiation and involved mechanisms are controversial. We investigated preconditioning, continuous, early, delayed treadmill on motor behavior, brain edema, inflammation, oxidative stress experimental traumatic injury (TBI).
Despite significant advances that have been made in the treatment of traumatic brain injury (TBI), it remains a global health issue. This study aimed to investigate synergistic effects 17-β estradiol (E2) and auraptene (AUR) on TBI treatment.
In spite of the great advances in field traumatic brain injury (TBI), it still remains as a global health problem. Phlebotomy has been mentioned an effective treatment for TBI Persian medicine. This study aimed to evaluate possible effect saphenous vein phlebotomy (SVP) on alleviation neuroinflammation and oxidative stress after TBI. Seventy-two adult male Wistar rats were randomly divided into three main groups: sham, + SVP group. Animal model was made through controlled cortical impactor...
Along with increased intracranial pressure (ICP) and brain damage, edema is the most common cause of death in patients hepatic encephalopathy. Curcumin can pass blood-brain barrier possesses anti-inflammatory anti-oxidant properties. This study focuses on curcumin protective effect intrahepatic extrahepatic damage brain. One hundred forty-four male Albino N-Mary rats were randomly divided into 2 main groups: injury group cholestasis group. In intra-hepatic was induced by intraperitoneal (IP)...