A5048318943- Skin Protection and Aging
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Tracheal and airway disorders
- Indoor Air Quality and Microbial Exposure
- Neural dynamics and brain function
- Ear Surgery and Otitis Media
- Photoreceptor and optogenetics research
- Oral health in cancer treatment
- Cutaneous Melanoma Detection and Management
- Nasal Surgery and Airway Studies
- Allergic Rhinitis and Sensitization
- Hearing, Cochlea, Tinnitus, Genetics
- Urban Green Space and Health
- Behavioral Health and Interventions
- Effects of Radiation Exposure
- Lung Cancer Treatments and Mutations
- Childhood Cancer Survivors' Quality of Life
- Neuroscience and Neural Engineering
- Radiomics and Machine Learning in Medical Imaging
- Peripheral Nerve Disorders
- Multiple and Secondary Primary Cancers
- Ear and Head Tumors
- Pleural and Pulmonary Diseases
Johns Hopkins University
2024-2025
University of Utah
2021-2024
University of Utah Hospital
2024
Johns Hopkins Medicine
2024
Michael E. DeBakey VA Medical Center
2013-2023
Baylor College of Medicine
2015-2023
MultiCare Health System
2023
Huntsman Cancer Institute
2019-2021
New York University
2010-2021
Harvard University
2016-2021
Rationale: Data regarding the sensitivity of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for staging lung cancer in patients with radiographic N0 disease is scant and inconsistent. With increasing use nonoperative ablative therapies, studies focusing on performance characteristics EBUS-TBNA this population are important.Objectives: To evaluate negative predictive value (NPV) non-small cell both by computed tomography (CT) positron emission (PET)-CT.Methods:...
<title>Abstract</title> Knowledge and discussion of family health history (FHH) can allow patients, families, communities to proactively monitor their communicate with providers identify genetic risk factors inform clinical decision-making. Under-resourced may face barriers in collecting, sharing, using FHH due competing priorities, literacy, medical mistrust. We characterized community opinions about a public Baltimore market. A paper survey was administered during biweekly fairs at the...
p27 is an atypical tumor suppressor that can regulate the activity of cyclin-dependent kinases and G0-to-S phase transitions. More recent studies reveal may also exhibit its tumor-suppressive function through regulating many other essential cellular events. However, molecular mechanisms underlying these anticancer effects are largely unknown. In this study, we found depletion expression by either gene knock-out or knockdown approaches resulted in up-regulation both Hsp27 Hsp70 at mRNA-...
Objective Rigid endoscopes can improve visualization of the tympanic space compared to traditional microscopic techniques. This study investigates whether use transcanal endoscopic ossiculoplasty influences audiologic outcomes following chronic ear surgery in children. Study Design Comparative cohort at two tertiary care centers. Methods Retrospective review pediatric cases where was performed from February 2009 March 2018. Results We identified 100 ears that underwent and ossiculoplasty....
To assess the effectiveness of depot octreotide for prevention diarrhea during pelvic radiation therapy.Patients receiving therapy (planned minimum dose, 45 Gy; 1.7 to 2.1 Gy daily) were eligible study. From May 10, 2002, through October 14, 2005, 125 patients randomly allocated in a double-blind fashion receive (100 microg, administered subcutaneously on day 1, followed by octreotide, 20 mg, intramuscularly days 2 and 29; n = 62) or placebo (n 63).Grade 0, 2, 3 observed 18%, 31%, 21% arm,...
Ultraviolet radiation (UVR) exposure is the primary modifiable risk factor for melanoma. Wearable UVR sensors provide a means of quantifying objectively and with lower burden than self-report measures used in most research. The purpose this study was to evaluate relationship between detected reported sunburn occurrence. In study, monitoring device worn by 97 parent–child dyads during waking hours 14 days measure instantaneous accumulated exposure. results showed that participants’ total...
Objectives To translate and validate the Zurich Chronic Middle Ear Inventory (ZCMEI‐21) for English language in order to provide an instrument assess health‐related quality of life chronic otitis media (COM). Design Pilot translation study including cognitive debriefings, prospective multicentre cross‐sectional psychometric validation study. Setting Four tertiary referral centres three different English‐speaking countries (UK, USA Australia). Participants Adult patients suffering from COM....
OBJECTIVES: Mobile apps are suggested for supporting home monitoring and reducing emergency department (ED) visits hospitalizations children with medical complexity (CMC). None have been implemented. We sought to assess the MyChildCMC app (1) feasibility CMC monitoring, (2) ability detect early deteriorations before ED hospital admissions, (3) preliminary impact. METHODS: Parents of (aged 1–21 years) admitted a children’s were randomly assigned or usual care. subjects recorded their child’s...
Stereotactic body radiation therapy (SBRT) is considered the standard treatment for medically inoperable early stage lung cancer. Bronchoscopy has shown to be effective in obtaining diagnosis of peripheral tumors, staging mediastinum (with endobronchial ultrasound- EBUS-), and placing fiducial markers (FMs). However, combination these 3 procedures a single bronchoscopy not been studied. The aim this study describe safety feasibility performing diagnosis, systematic nodal staging, placement...
Background In the United States, melanoma is fifth most common type of cancer. Reducing UV radiation (UVR) exposure essential for prevention melanoma. The assessment individual-level UVR using wearable technology a promising method to monitor and reduce exposure. However, feasibility acceptability monitoring devices have not been assessed. Objective This study aimed assess commercially available device in adults children. Methods We recruited families (1 parent 1 child) test new, (namely,...
Emerging UV radiation (UVR) monitoring devices may present an opportunity to integrate such technology into skin cancer prevention interventions. However, little is known about the effects of using a wearable UVR monitor on adults' and children's sun protection-related behaviors attitudes (eg, worry perceived risk). Understanding potential role reactivity seasonal will help inform use objective monitors in context research, including intervention studies.The aim this study examine associated...
Patients with lung cancer sometimes present multiple primary cancers (MPLCs), either simultaneously (synchronous) or after treatment of an initial lesion (metachronous). Although open surgery remains a mainstay for patients stage I-II non-small-cell (NSCLC), stereotactic body radiation therapy (SBRT) is acceptable alternative who are medically unfit refuse surgery. In this study, we retrospectively examine the outcome among early-stage MPLCs treated at our institution SBRT.Patients receiving...
To investigate the patterns of care and outcomes treatment early stage tonsil cancers, controlling for human papillomavirus (HPV) status.Historical cohort study.National Cancer Database (NCDB).Review NCDB between 2010 2017 all T1-2N0M0 tonsillar squamous cell carcinoma (SCC). Demographics, clinical characteristics, HPV status, regimens, survival were analyzed.A total 4720 patients identified with SCC tonsil. Most tested (2759 [58.5%]). Among patients, 1758 (63.7%) positive 1001 (36.3%)...
Knowledge and discussion of family health history (FH) allows patients, families, communities to proactively monitor their communicate with providers identify genetic risk factors access preventive guidance, screening, testing. Under-resourced may face barriers in obtaining, sharing, using FH due other priorities, literacy, variations perceived definition family, medical institution mistrust. Previous community stakeholders' opinions highlighted the opportunity for improvement awareness via...
Genetic variation among inhaled corticosteroid (ICS)-metabolizing enzymes may affect asthma control, but evidence is limited. This study tested the hypothesis that single-nucleotide polymorphisms (SNPs) in Cytochrome P450 3A5 (CYP3A5) would outcomes. Patients aged 2-18 years with persistent were recruited to use electronic AsthmaTracker (e-AT), a self-monitoring tool records weekly medication use, and A subset of patients provided saliva samples for SNP analysis participated pharmacokinetic...
<h3>Introduction</h3> Surgical treatment is the only definitive to halt progression of neuromuscular scoliosis (NMS) but associated with complication rates 17–40%. Caregivers experience considerable uncertainty during decision-making. This study aims identify topics for which a concern caregivers and how interpret that uncertainty. <h3>Methods</h3> From two quaternary children's hospitals, we recruited English- Spanish-speaking adult children aged 8–21 years NMS who had previously decided...