A5047998085- Immune responses and vaccinations
- Stress Responses and Cortisol
- Posttraumatic Stress Disorder Research
- Dementia and Cognitive Impairment Research
- Influenza Virus Research Studies
- Alzheimer's disease research and treatments
- SARS-CoV-2 and COVID-19 Research
- Anesthesia and Neurotoxicity Research
- Acute Myocardial Infarction Research
- Radiation Dose and Imaging
- Cardiac Imaging and Diagnostics
- Vaccine Coverage and Hesitancy
- Psychosomatic Disorders and Their Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacterial Infections and Vaccines
- Functional Brain Connectivity Studies
- Mental Health Treatment and Access
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Aging and Gerontology Research
- Machine Learning in Healthcare
- Genetic Neurodegenerative Diseases
- Resilience and Mental Health
The University of Texas Health Science Center at Houston
2015-2024
Massachusetts General Hospital
2023-2024
Memorial Hermann–Texas Medical Center
2019
Prior studies have found a reduced risk of dementia any etiology following influenza vaccination in selected populations, including veterans and patients with serious chronic health conditions. However, the effect on Alzheimer's disease (AD) general cohort older US adults has not been characterized.To compare incident AD between without prior large claims database.Deidentified data spanning September 1, 2009 through August 31, 2019 were used. Eligible free during 6-year look-back period...
Accumulating evidence suggests that adult vaccinations can reduce the risk of developing Alzheimer's disease (AD) and related dementias.To compare for AD between adults with without prior vaccination against tetanus diphtheria, or pertussis (Tdap/Td); herpes zoster (HZ); pneumococcus.A retrospective cohort study was performed using Optum's de-identified Clinformatics® Data Mart Database. Included patients were free dementia during a 2-year look-back period were≥65 years old by start 8-year...
A growing literature supports a protective association between vaccines targeting an array of pathogens (e.g., influenza, pneumococcus, herpes zoster) and the risk Alzheimer disease (AD). This article discusses potential underlying mechanisms for this apparent effect immunizations against infectious on AD; explores basic pharmacoepidemiologic evidence association, with particular attention paid to important methodological variations among epidemiologic studies; reviews remaining...
Alzheimer's disease (AD) varies a great deal cognitively regarding symptoms, test findings, the rate of progression, and neuroradiologically in terms atrophy on magnetic resonance imaging (MRI). We hypothesized that an unbiased analysis progression AD, clinical MRI features, will reveal number AD phenotypes. Our objective is to develop use computational method for multi-modal changes cognitive scores volumes there being multiple In this retrospective cohort study with total 857 subjects from...
Background: Accurately identifying cognitive changes in Mexican American (MA) adults using the Mini-Mental State Examination (MMSE) requires knowledge of population-based norms for MMSE, a scale which has widespread use research settings. Objective: To describe distribution MMSE scores large cohort MA adults, assess impact requirements on their clinical trial eligibility, and explore factors are most strongly associated with scores. Methods: Visits between 2004–2021 Cameron County Hispanic...
The rate of progression Alzheimer's disease (AD) differs dramatically between patients. Identifying the most is critical because when their numbers differ treated and control groups, it distorts outcome, making impossible to tell whether treatment was beneficial. Much recent effort, then, has gone into identifying RPs. We pooled de-identified placebo-arm data three randomized controlled trials (RCTs), EXPEDITION, EXPEDITION 2, 3, provided by Eli Lilly Company. After processing, included 1603...
The goal of this retrospective cohort study was to determine whether stressors related military service, determined by a diagnosis chronic post-traumatic stress disorder (cPTSD) or receiving Purple Heart (PH), are associated with an increased risk vascular factors and disease, which great concern for veterans, who constitute significant portion the aging US population. Veterans Integrated Service Network (VISN) 16 administrative database searched individuals 65 years older between October 1,...