A5050661448- T-cell and B-cell Immunology
- Mast cells and histamine
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Eosinophilic Esophagitis
- Cell Adhesion Molecules Research
- Allergic Rhinitis and Sensitization
- Neuroinflammation and Neurodegeneration Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Chemokine receptors and signaling
- Asthma and respiratory diseases
- Trauma Management and Diagnosis
Inserm
2018-2024
Centre d’Immunologie de Marseille-Luminy
2018-2024
Centre National de la Recherche Scientifique
2018-2024
Aix-Marseille Université
2018-2024
Rockefeller University
2024
Mast cells (MCs) are tissue-resident immune that exhibit homeostatic and neuron-associated functions. Here, we combined whole-tissue imaging single-cell RNA sequencing datasets to generate a pan-organ analysis of MCs in mice humans at steady state. In mice, identify two mutually exclusive MC populations, MrgprB2+ connective tissue–type MrgprB2neg mucosal-type MCs, with specific transcriptomic core signatures. While develop utero independently the bone marrow, after birth renewed by marrow...
Gut-draining mesenteric lymph nodes (mLNs) are important for inducing peripheral tolerance towards food and commensal antigens by providing an optimal microenvironment de novo generation of Foxp3+ regulatory T cells (Tregs). We previously identified microbiota-imprinted mLN stromal as a critical component in induction. Here we show that this imprinting process already takes place the neonatal phase, renders cell compartment resistant to inflammatory perturbations later life. LN...
Immunoglobulin M (IgM) is the first type of antibody produced during acute infections and thus provides an early line specific defense against pathogens. Being in secondary lymphoid organs, IgM must rapidly be exported to blood circulation. However, it currently unknown how such large pentameric molecules are released from lymph nodes (LNs). Here, we show that upon immunization, transiently gains access luminal side conduit system, a reticular infrastructure enabling fast delivery...
Abstract Mast cells (MCs) are heterogenous tissue-resident immune associated with blood vessels and neurons. However, the extent to which specialized MCs can exhibit micro-environment-specific functions is unclear. Using single cell RNA sequencing, we characterize connective tissue-type mucosal across organs found that they be discriminated based on MrgprB2 expression. While + enriched in neuroreceptors, develop during embryogenesis renew independently of bone marrow (BM); neg arise...