Yen Le

ORCID: 0000-0002-7196-4937
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About
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Research Areas
  • Cystic Fibrosis Research Advances
  • Plant Molecular Biology Research
  • Polysaccharides and Plant Cell Walls
  • Medicinal Plants and Neuroprotection
  • Tracheal and airway disorders
  • Medicinal Plant Research
  • Neonatal Respiratory Health Research
  • Photosynthetic Processes and Mechanisms
  • Microtubule and mitosis dynamics
  • Natural Antidiabetic Agents Studies
  • Plant Reproductive Biology

Czech Academy of Sciences, Institute of Physiology
2024

Respiratory Clinical Trials
2024

University of Saskatchewan
2020-2021

Ho Chi Minh City University of Science
2011

Pulmonary ionocytes are a newly discovered airway epithelial cell type proposed to be major contributor cystic fibrosis (CF) lung disease based on observations they express the transmembrane conductance regulator (CFTR) anion channel at higher level than any other in epithelia. Moreover, genetically manipulated experimental models that lack develop NaCl transport abnormalities and surface liquid (ASL) dehydration consistent with CF. However, no direct evidence indicates engage or contribute...

10.1164/rccm.202309-1565oc article EN American Journal of Respiratory and Critical Care Medicine 2024-04-04

Abstract Leaf spongy mesophyll cells form an interconnected network of branched and intercellular spaces to maximize the surface area available for light capture photosynthetic gas exchange. To investigate morphogenetic events leading cell separation branching in Arabidopsis thaliana, we used mesophyll-specific promoters facilitate imaging shape microtubule (MT) organization over multiple spatiotemporal scales without interference from overlying epidermal cells. We show that enlarge by...

10.1093/plcell/koaa036 article EN The Plant Cell 2020-12-18

A controversial hypothesis pertaining to cystic fibrosis (CF) lung disease is that the CF transmembrane conductance regulator (CFTR) channel fails inhibit epithelial Na+ (ENaC), yielding increased reabsorption and airway dehydration. We use a non-invasive self-referencing Na+-selective microelectrode technique measure transport across individual folds of distal surface epithelium preparations from CFTR−/− wild-type (WT) swine. show that, under unstimulated control conditions, WT epithelia...

10.1016/j.celrep.2021.109795 article EN cc-by-nc-nd Cell Reports 2021-10-01

Extracts from Drosera species have been published as therapeutics, especially antioxidants. In this research, quercetin was screened and isolated for antioxidant properties D. indica L. in vitro plantlets. Its structure has elucidated on the basic of its spectral data mainly, 1H-, 13C-NMR, DEPT COSY, HSQC, HMBC. HPLC also applied quantitative analysis quercetin.

10.32508/stdj.v14i3.1986 article EN Science and Technology Development Journal 2011-09-30
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