A5051943441- Veterinary Medicine and Surgery
- Human-Animal Interaction Studies
- Diet and metabolism studies
- HIV/AIDS drug development and treatment
- Drug Transport and Resistance Mechanisms
- Dermatology and Skin Diseases
- Trace Elements in Health
- Veterinary Equine Medical Research
- Veterinary Oncology Research
- Virus-based gene therapy research
- Probiotics and Fermented Foods
- Hepatitis C virus research
- Muscle metabolism and nutrition
- HIV Research and Treatment
- Alcoholism and Thiamine Deficiency
- Kidney Stones and Urolithiasis Treatments
- Biochemical Acid Research Studies
- Pediatric Urology and Nephrology Studies
- Gut microbiota and health
- Animal Nutrition and Physiology
- Pharmacogenetics and Drug Metabolism
- Peroxisome Proliferator-Activated Receptors
- Healthcare Systems and Technology
- Hepatitis B Virus Studies
- Reproductive Physiology in Livestock
Hill's Pet Nutrition (United States)
2015-2024
Celerion (United States)
2015-2017
University of Minnesota
2015
American College
2015
Hill Top Research (United States)
2015
Michigan State University
2015
A microdose cocktail containing midazolam, dabigatran etexilate, pitavastatin, rosuvastatin, and atorvastatin has been established to allow simultaneous assessment of a perpetrator impact on the most common drug metabolizing enzyme, cytochrome P450 (CYP)3A, major transporters organic anion‐transporting polypeptides (OATP)1B, breast cancer resistance protein (BCRP), MDR1 P‐glycoprotein (P‐gp). The clinical utility these probe substrates was qualified by conducting interaction studies with...
Abstract Objective —To determine the effects of feeding a diet supplemented with fish oil omega-3 fatty acids on carprofen dosage in dogs osteoarthritis. Design —Randomized, controlled, multisite clinical trial. Animals —131 client-owned stable chronic osteoarthritis examined at 33 privately owned veterinary hospitals United States. Procedures —In all dogs, was standardized over 3-week period to approximately 4.4 mg/kg/d (2 mg/lb/d), PO. Dogs were then randomly assigned receive food or...
To develop morphometric equations for prediction of body composition and create a fat index (BFI) to estimate percentage in overweight obese dogs.Prospective evaluation study.83 or dogs ≥ 1 year age.Body condition score (BCS) was assessed on 5-point scale, measurements were made, visual palpation-based assessments dual-energy x-ray absorptiometry (DEXA) performed. Equations predicting lean mass, as total weight (ie, percentage) the basis generated with best-fit statistical models. Visual...
Abstract OBJECTIVE To examine the effects of age, sex, year death/sample collection, and liver histopathology on copper concentrations in dogs fed a wide variety commercial dog foods throughout their lives. METHODS This study utilized all bioarchived samples collected during necropsy at time death from 2006 to 2022 housed closed feeding colony. Liver were analyzed dry matter basis for concentration by inductively coupled plasma-optical emission spectrometry did not require specific criteria...
To develop morphometric equations for prediction of body composition and create a fat index (BFI) system to estimate percentage in overweight obese cats.Prospective evaluation study.76 or cats ≥ 1 year age.Body condition score (BCS) was determined with 5-point scale, measurements were made, dual-energy x-ray absorptiometry (DEXA) performed. Visual palpation-based various regions conducted, results used development the BFI system. Best-fit multiple regression models predicting lean mass from...
To evaluate the effect of nutrition on recurrent clinical signs lower urinary tract (LUT) disease in cats with idiopathic cystitis.Randomized, controlled, masked trial.31 acute nonobstructive cystitis.Cats were assigned to receive 1 2 foods (a cystitis prevention or control food) that differed mineral (calcium, phosphorous, and magnesium), antioxidant, fatty acid profiles. Owners documented LUT daily for up year. The primary endpoint was number episodes which a cat had multiple (≥...
Diminished appetite and poor eating behavior accompanied by weight loss or cachexia are often reported in dogs living with cancer. This study was conducted to determine the acceptance enthusiasm cancer for a new therapeutic, nutritionally balanced, calorically dense food designed Adult diagnosis of were recruited from general oncology practices fed 28 days. Evaluations included physical examination, body weight, intake, caloric hematology serum biochemistry, owner assessments, namely...
A healthy gastrointestinal (GI) microbiome has been shown to be essential for proper nutrient absorption and metabolism, maintenance of intestinal epithelial integrity osmolarity, gut immunomodulation, overall health. One the most effective ways promote a GI is through dietary interventions, such as addition prebiotics. Prebiotics are substrates that selectively utilized by host fermentation confer health benefit. However, research on prebiotics in companion animals limited, especially...
Raltegravir is a human immunodeficiency virus (HIV)-1 integrase strand transfer inhibitor currently marketed at dose of 400 mg twice-daily (b.i.d.). 1200 once-daily (q.d.) (investigational q.d. formulation 2 × 600 tablets; RAL) was found to be generally well tolerated and non-inferior the b.i.d. 48 weeks in phase 3 trial. Since raltegravir eliminated mainly by metabolism via uridine diphosphate glucuronosyltransferase (UGT) 1A1-mediated glucuronidation pathway, co-administration UGT1A1...
Renal foods are used to manage chronic kidney disease (CKD) in dogs and cats, but their effectiveness may be limited by the ability transition animals them.In a prospective study, pet cats with previously undiagnosed (20 International Interest Society (IRIS) 1, 61 IRIS 2, 14 3/4, 33 at risk for CKD) were transitioned renal food. Markers of function measured owners answered questionnaires about over one year.All eight (120/128; 94 per cent) successfully Most time, moderately or extremely...
Abstract Raltegravir is a human immunodeficiency virus (HIV)‐1 integrase strand transfer inhibitor currently marketed at dose of 400 mg twice daily (BID). for once regimen (QD) 1200 (2 x 600 mg) under development and offers new treatment option HIV‐1 infected treatment‐naive subjects. Since raltegravir eliminated mainly by metabolism via an UDP‐glucuronosyltransferase (UGT) 1 A1‐mediated glucuronidation pathway, co‐administration UGT1A1 inducers may alter plasma levels raltegravir....
This study was designed to determine the effect of alpha-lipoic acid on glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed food containing no acid, randomly allocated into four groups. Groups then nutritionally complete and balanced with either 0, 75, 150 or 300 ppm added for 6 months. Evaluations included physical examination, body weight, intake, hematology, serum biochemistry profile measurements plasma erythrocyte lysates....
Abstract Background Adverse reactions to food are a common dermatological condition in dogs, requiring nutritional intervention using novel or hydrolysate protein‐based foods. Objective To evaluate therapeutic containing egg and phytonutrients dogs with allergies an activity monitor core outcome set for canine atopic dermatitis (COSCAD'18) controlled double‐masked, multicenter, prospective clinical trial. Animals Adult history of adverse reaction as diagnosed by elimination trial were...
Relative supersaturation (RSS) values for urine crystals are a measure of the risk urinary stone formation and have been shown to be lowered in foods aid management urolithiasis. In order calculate RSS pets, computer programs developed understanding veterinary medicine. However, some older not updated use animals, specific coefficients used publically available. One first was BASIC language published 1985 which called EQUIL2. The EQUIL2 program compiled version compatible with PC platform....
Uroliths are concretions formed in the urinary tract. These can be problematic humans and companion animals such as cats. Magnesium ammonium phosphate (struvite) calcium oxalate (CaOx) most common forms of uroliths. The relative supersaturation (RSS) is a risk index crystal formation. Here, an updated program for calculating RSS, EQUIL-HL21, was used to detect differences RSS values when cats were fed foods formulated non-urinary conditions. In addition, contributions analytes examined via...
Abstract Background Adverse reactions to food are a common dermatological condition in dogs, requiring nutritional intervention using novel or hydrolysate protein‐based food. Objective To evaluate therapeutic containing egg and phytonutrients dogs with allergies an activity monitor core outcome set for canine atopic dermatitis (COSCAD'18) guidelines controlled double‐masked, multicenter, prospective clinical trial. Animals Adult history of adverse reaction as diagnosed by elimination trial...
The objective of this study was to assess serum chemistries and metabolomic parameters in cats with genetic variants the alanine-glyoxylate aminotransferase 2 (AGXT2) gene determine abnormalities associated urolith formation better understand effective approaches for treatment uroliths.
To examine the effects of age, sex, breed, liver histopathology, and year death/sample collection on copper concentrations in dogs fed various commercial dog foods throughout their lives.
<title>Abstract</title> The full text of this preprint has been withdrawn by the authors in order to comply with an institutional policy on preprints. Therefore, do not wish work be cited as a reference.