A5034847300- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Rabies epidemiology and control
- Monoclonal and Polyclonal Antibodies Research
- Vector-borne infectious diseases
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Escherichia coli research studies
- Viral Infections and Vectors
- Antibiotic Resistance in Bacteria
- Toxin Mechanisms and Immunotoxins
- Influenza Virus Research Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Yersinia bacterium, plague, ectoparasites research
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Respiratory viral infections research
- Immune responses and vaccinations
- Virology and Viral Diseases
- COVID-19 diagnosis using AI
National Center of Infectious and Parasitic Diseases
2021-2024
Abstract Genomic sequencing is essential to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments, vaccines, guide public health responses. To investigate global SARS-CoV-2 genomic surveillance, we used sequences shared via GISAID estimate impact intensity turnaround times on variant detection in 189 countries. In first two years pandemic, 78% high-income countries sequenced >0.5% their COVID-19 cases, while 42% low- middle-income reached that mark. Around 25%...
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has brought about significant challenges worldwide. In this study, we present a comprehensive analysis of the genomic epidemiology and lineage dynamics SARS-CoV-2 in Bulgaria over three-year period. Through extensive sequencing data analysis, investigated evolution virus, emergence variants concern (VOCs), their impact on country's trajectory. We also assessed relationship between viral diversity...
Abstract Social distancing, mask‐wearing, and travel restrictions during the COVID‐19 pandemic have significantly impacted spread of influenza viruses. The objectives this study were to analyze pattern virus circulation with respect that severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in Bulgaria 2021–2022 season perform a phylogenetic/molecular analysis hemagglutinin ( HA ) neuraminidase NA sequences representative strains. Influenza infection was confirmed using real‐time...
Background. Evolution of the emerging SARS-CoV-2 variants raises concerns about possibility accelerated transmission, disease severity, diagnostic challenges, and reduced vaccine effectiveness in ever-evolving COVID-19 pandemic worldwide. Objectives for this study were to build a comprehensive national system monitoring genomic surveillance identify introduced virus country. Methods. We analyzed infections 7948 representative clinical samples collected medical institutions different...
The COVID-19 pandemic is associated with high morbidity and significant mortality worldwide. objective of this study was to track the circulation pattern SARS-CoV-2 in Bulgaria over three consecutive years (2020-2022) analyze involvement cases co-infections. A total 98 247 clinical samples were tested for using a Real-Time RT-PCR method 25.2% them positive. positive rate greater among hospitalized patients compared outpatients (p<0.05). Approximately 48.3% all SARS-CoV-2-positive male...
Abstract The evolution of the emerging SARS‐CoV‐2 variants carrying mutations in spike protein raises concerns about possibility accelerated transmission ever‐evolving COVID‐19 pandemic worldwide. AY.4.2, a sublineage Delta variant, was considered variant under investigation (VUI) and also gained nickname “Delta Plus,” due to its extra mutations, Y145H A222V. In this study, using genomic epidemiology, we provide first insights into introduction AY.4.2 Bulgaria AY.4.2.1 that found larger...
This study is aimed to assess the prevalence of Coxiella burnetii infection among veterinary medicine students from two Bulgarian Universities, located in Sofia and Stara Zagora. A total 185 blood samples were collected tested for detection C. phase II antibodies presence DNA using an enzyme-linked immunosorbent assay (ELISA) end-point PCR test, respectively. Out all samples, 29.7% positive at least one antibody marker or by test. Veterinary Zagora showed significantly seropositive status Q...
The aim of this study was to assess the prevalence
The first recombinant SARS-CoV-2 variants were identified in 2022, causing public health concerns. importance of has increased especially since the WHO designated variant XBB and its lineages as subvariants that require monitoring on 20 November 2022. In this study, we provide insights into new named XAN, a composed Omicron sub-lineages BA.2 BA.5. To our knowledge, is report XAN Bulgaria.
Objectives: Community and hospital acquired K. pneumoniae infections have become a ubiquitous medical issue due to the limited treatment options high mortality rate therefore aims of this study are in vitro investigation double antimicrobial combinations against multidrug resistant (MDR) extensively drug (XDR) isolates.
 Materials Methods: Antimicrobial susceptibility twelve isolates from eight Bulgarian hospitals was determined interaction effect selected accordance fractional...
SARS-CoV-2 is a highly contagious virus, which appeared in China late 2019, spread rapidly and caused the largest pandemic last 100 years. Despite intensive research, there no specific antiviral drug currently. Effective vaccines have been developed short time they are already widely used. As RNA mutates constantly, several thousand genetic variants emerged course of pandemic, some associated with increased infectivity, reinfection risk, reduced activity therapeutic antibodies effectiveness...
SPR method was applied for studding the herpes simplex virus replication kinetic in human cells and inhibitory effect of acyclovir. The obtained results were compared with classical endpoint quantification techniques