A5033224747- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Virus-based gene therapy research
- COVID-19 epidemiological studies
University of Saskatchewan
2022-2024
Abstract Post-acute sequelae of COVID-19 (PASC) or the continuation (Coronavirus disease 2019) symptoms past 12 weeks may affect as many 30% people recovering from a SARS-CoV-2 (severe acute respiratory coronavirus 2) infection. The mechanisms regulating development PASC are currently not known; however, hypotheses include virus reservoirs, pre-existing conditions, microblood clots, immune dysregulation, well poor antibody responses. Importantly, neutralizing antibodies essential for...
Abstract SARS-CoV-2 variants and seasonal coronaviruses continue to cause disease in the animal reservoir pose a constant spillover threat. Importantly, understanding of how previous infection may influence future exposures, especially context variants, is still limited. Here we adopted step-wise experimental approach examine primary immune response subsequent recall toward antigenically distinct using male Syrian hamsters. Hamsters were initially inoculated with (HCoV-NL63, HCoV-229E, or...
Abstract Coronaviruses are a significant threat to public health, animal welfare, and economic stability. SARS-CoV-2 seasonal coronaviruses continue cause disease in the reservoir pose constant spillover threat. Immunological imprinting is term meant represent strong influence of first viral infection on outcome subsequent related infections or vaccination, with “Original Antigenic Sin” having historically been applied potential negative effects such imprinting. Little known, however, about...
<title>Abstract</title> Post-acute sequelae of COVID-19 (PASC) or the continuation (Coronavirus disease 2019) symptoms past 12 weeks may affect as many 30% people recovering from a SARS-CoV-2 (severe acute respiratory coronavirus 2) infection. The mechanisms regulating development PASC are currently not known; however, hypotheses including poor antibody responses have been suggested. Due to importance virus neutralizing antibodies during recovery and protection reinfection, we designed...