A5059196177- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Ocular Infections and Treatments
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- COVID-19 and Mental Health
- Prion Diseases and Protein Misfolding
- Long-Term Effects of COVID-19
- Posttraumatic Stress Disorder Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Healthcare professionals’ stress and burnout
- Hemodynamic Monitoring and Therapy
- Cancer therapeutics and mechanisms
- Bacterial Infections and Vaccines
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Food Allergy and Anaphylaxis Research
- Antimicrobial agents and applications
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Stress and Burnout Research
- Bacterial Genetics and Biotechnology
- Ocular Diseases and Behçet’s Syndrome
- Blood Pressure and Hypertension Studies
University of Saskatchewan
2004-2025
Royal University Hospital
2003-2024
Dalhousie University
2023
Saskatoon Medical Imaging
2014
Abstract Post-acute sequelae of COVID-19 (PASC) or the continuation (Coronavirus disease 2019) symptoms past 12 weeks may affect as many 30% people recovering from a SARS-CoV-2 (severe acute respiratory coronavirus 2) infection. The mechanisms regulating development PASC are currently not known; however, hypotheses include virus reservoirs, pre-existing conditions, microblood clots, immune dysregulation, well poor antibody responses. Importantly, neutralizing antibodies essential for...
Transmissible spongiform encephalopathies (TSEs), or prion diseases, represent a unique form of infectious disease based on misfolding self-protein (PrP C ) into pathological, conformation Sc ). Prion diseases food animals gained notoriety during the bovine encephalopathy (BSE) outbreak 1980s. In particular, transmission to humans, generation fatal, untreatable disease, elevated perspective livestock from production safety. While immediate threat posed by BSE has been successfully addressed...
Prions are a novel form of infectivity based on the misfolding self-protein (PrPC) into pathological, infectious isomer (PrPSc). The current uncontrolled spread chronic wasting disease in cervids, coupled with demonstrated zoonotic nature select livestock prion diseases, highlights urgent need for management tools. While there is proof-of-principle evidence vaccine, these efforts complicated by challenges and risks associated induction immune responses to self-protein. Our priority develop...
Delirium is common after cardiac surgery and associated with adverse outcomes. Administration of benzodiazepines before delirium; guidelines recommend minimizing their use. Benzodiazepine administration during remains because its recognized benefits. The Benzodiazepine-Free Cardiac Anesthesia for Reduction Postoperative (B-Free) trial a randomized cluster crossover evaluating whether an institutional policy restricting intraoperative benzodiazepine (ie, ≥ 90% patients do not receive...
Purpose. Haemophilus influenzae is a known ocular pathogen, particularly in the pediatric population. The purpose of this study was to determine minimal inhibitory concentration (MIC) and mutant prevention (MPC) values third-generation (i.e., ciprofloxacin ofloxacin) fourth-generation gatifloxacin moxifloxacin) fluoroquinolone antibiotics against clinical isolates H. influenzae. Methods. Twenty-six were evaluated. For MIC testing, approximately 105 colony-forming units/mL test organism added...
Introduction Older patients undergoing cardiac surgery carry the highest risk for developing major postoperative neurocognitive disorder (postoperative NCD or P-NCD) with up to 25% incidence 3 months after surgery. P-NCD is associated significant morbidity, mortality, loss of independence, premature retirement and increased healthcare costs. This multicentre randomised trial investigating efficacy dexmedetomidine sedation in reducing compared standard protocols. CODEX will be largest...
RiassuntoL’aumento continuo di antibiotico resistenza in patogeni dell’uomo ed il ristretto numero nuovi antimicrobici fase sviluppo rendono fondamentale importanza le conoscenze sulla batterica, relativamente sia ai meccanismi insorgenza, ad ogni potenziale strategia per rallentare l’incremento dei tassi resistenza. Gli studi effettuati con i fluorochinoloni hanno dato origine al concetto “concentrazione prevenzione della mutazione” (MPC), che rappresenta un nuovo parametro misurare la...
<title>Abstract</title> Post-acute sequelae of COVID-19 (PASC) or the continuation (Coronavirus disease 2019) symptoms past 12 weeks may affect as many 30% people recovering from a SARS-CoV-2 (severe acute respiratory coronavirus 2) infection. The mechanisms regulating development PASC are currently not known; however, hypotheses including poor antibody responses have been suggested. Due to importance virus neutralizing antibodies during recovery and protection reinfection, we designed...