A5001909760- Prion Diseases and Protein Misfolding
- Monoclonal and Polyclonal Antibodies Research
- Trace Elements in Health
- Neurological diseases and metabolism
- Viral Infections and Immunology Research
- Bacteriophages and microbial interactions
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Restraint-Related Deaths
- Stroke Rehabilitation and Recovery
- Bacterial Infections and Vaccines
- Food Allergy and Anaphylaxis Research
- Oral and Maxillofacial Pathology
- vaccines and immunoinformatics approaches
- Brain Metastases and Treatment
- Infectious Diseases and Tuberculosis
- Glioma Diagnosis and Treatment
- Bacterial Genetics and Biotechnology
- Animal Disease Management and Epidemiology
- Lipid metabolism and disorders
- HIV Research and Treatment
- Celiac Disease Research and Management
- Immunotherapy and Immune Responses
- Diet and metabolism studies
- Traumatic Ocular and Foreign Body Injuries
University of Saskatchewan
2013-2025
Saskatoon Medical Imaging
2013-2014
BACKGROUND H3K27M-altered diffuse midline glioma (DMG) is a recently classified tumor in the 2021 WHO classification of central nervous system tumors. Pediatric patients with DMG have universally poor prognosis, median survival 9–15 months. The prognosis adult same type more variable, rare cases prolonged survival. OBSERVATIONS authors report case 32-year-old male who presented Brown-Séquard syndrome secondary to heterogeneously enhancing intramedullary mass extending from T7 T10. lesion was...
Emerging evidence suggests seeding and prion-like propagation of mutant Superoxide Dismutase 1 (SOD1) misfolding to be a potential mechanism for ALS pathogenesis progression. Immuno-targeting misfolded SOD1 has shown positive clinical outcomes in transgenic mice. However, major challenge developing active immunotherapies proteinopathies such as is the design immunogens enabling exclusive recognition pathogenic species self-protein. Ideally, one would achieve robust antibody response against...
Prions are a novel form of infectivity based on the misfolding self-protein (PrPC) into pathological, infectious isomer (PrPSc). The current uncontrolled spread chronic wasting disease in cervids, coupled with demonstrated zoonotic nature select livestock prion diseases, highlights urgent need for management tools. While there is proof-of-principle evidence vaccine, these efforts complicated by challenges and risks associated induction immune responses to self-protein. Our priority develop...
Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases that based on the misfolding of a cellular prion protein (PrP(C)) into an infectious, pathological conformation (PrP(Sc)). There is proof-of-principle evidence vaccine possible but this tempered with concerns potential dangers associated induction immune responses to widely-expressed self-protein. By targeting epitopes specifically exposed upon misfolding, our group developed induces PrP(Sc)-specific...
Abstract Summary: Efforts to develop peptide-based vaccines, in particular those requiring site-specific targeting of self-proteins, rely on the ability optimize immunogenicity peptide epitopes. Currently, screening candidate vaccines is typically performed through low-throughput, high-cost animal trials. To improve this we present program EpIC, which enables high-throughput prediction based endogenous occurrence B-cell epitopes within native protein sequences. This information informs...
The initiation of bacteriophage λ replication depends upon interactions between the oriλ DNA site, phage proteins O and P, E. coli host proteins. P exhibits a high affinity for DnaB, major replicative helicase unwinding double stranded DNA. concept P-lethality relates to hypothesis that can sequester DnaB in turn prevent cellular from oriC. Alternatively, it was suggested does not involve an interaction but is targeted DnaA. assessed by examining cells transformation ColE1-type plasmids...
Prion diseases reflect the misfolding of a self-protein (PrP(C)) into an infectious, pathological isomer (PrP(Sc)). By targeting epitopes uniquely exposed by misfolding, our group developed PrP(Sc)-specific vaccines to 3 disease specific (DSEs). Here, antibodies induced individual DSE are evaluated for their capacity neutralize prions in vitro. For both purified and immunoreactive sera, were equally effective neutralizing prions. Further, there was no significant increase activity when...
Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative disorders caused by misfolding of a cellular protein PrPC into an infectious conformation PrPSc. Previously our group demonstrated induction PrPSc-specific antibodies with SN6b vaccine that targets regions the exposed upon misfolding. There concerns these could function as templates to promote and cause disease. To evaluate consequences prolonged exposure in prion sensitized animal, tga20 mice were vaccinated...
Tuberculosis is an airborne disease caused by Mycobacterium tuberculosis. Intracranial tuberculoma a rare complication of extrapulmonary tuberculosis due to hematogenous spread subpial and subependymal regions. can occur with or without meningitis.A 3-year-old male who had recently emigrated from Sudan presented the emergency department right-sided seizures lasting 30 minutes, which were aborted levetiracetam midazolam. Head computed tomography revealed multilobulated left supratentorial...
Intracranial penetrating injuries from a pencil are exceptionally rare. The most common mechanism is child running while holding pencil. Potential consequences of intracranial injury include direct trauma to brain structures, vascular injury, and abscess formation.
Numerous studies have shown longer pre-hospital and in-hospital workflow times poorer outcomes in women after acute ischemic stroke (AIS) general endovascular treatment (EVT) particular. We investigated sex differences care of EVT patients over 5 years a comprehensive Canadian provincial registry.Clinical data all AIS who underwent between January 2017 December 2022 the province Saskatchewan were captured OPTIMISE registry supplemented with patient from administrative sources. Patient...
Species, as well individuals within species, have unique susceptibilities to prion infection that are likely based on sequence differences in cellular protein (PrPC). Species barriers transmission also reflect PrPC differences. Defining the structure-activity relationship of PrPC/PrPSc with respect infectivity/susceptibility will benefit disease understanding and assessment risks. Here, nanopore analysis is employed investigate genotypes sheep corresponding differential scrapie infection....