A5055642255- Congenital heart defects research
- Aortic Disease and Treatment Approaches
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Connective tissue disorders research
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Radiation Dose and Imaging
- Sperm and Testicular Function
- Science and Education Research
- Healthcare Regulation
- Cardiovascular Effects of Exercise
- Pluripotent Stem Cells Research
- Selenium in Biological Systems
- Metabolism, Diabetes, and Cancer
- Health and Lifestyle Studies
- Nutrition and Health in Aging
- Effects of Radiation Exposure
- Ultrasound and Hyperthermia Applications
- COVID-19 and healthcare impacts
- Public Health in Brazil
- Cardiovascular Function and Risk Factors
- Medical Imaging Techniques and Applications
- Education during COVID-19 pandemic
- Infection Control and Ventilation
State University of Norte Fluminense
2006-2024
Instituto Nacional de Cardiologia
2015-2022
Ministério da Saúde
2018-2020
Universidade do Estado do Rio de Janeiro
2017
Federal Center for Technological Education Celso Suckow da Fonseca
2017
The Study of Cardiovascular Risk in Adolescents (Portuguese acronym, "ERICA") is a multicenter, school-based country-wide cross-sectional study funded by the Brazilian Ministry Health, which aims at estimating prevalence cardiovascular risk factors, including those included definition metabolic syndrome, random sample adolescents aged 12 to 17 years cities with more than 100,000 inhabitants. Approximately 85,000 students were assessed public and private schools. Brazil continental country...
Abstract: The Study of Cardiovascular Risk in Adolescents (ERICA) is a pioneering study that aimed to assess the prevalence cardiovascular risk factors, including metabolic syndrome components Brazilian adolescents. This aims describe methodological aspects related blood collection as well report pertaining results preparation, transport, storage, and exams ERICA. Exams ERICA were performed single laboratory samples collected schools standardized manner. Logistics involved air transportation...
Four human iPSC cell lines (one Jervell and Lange-Nielsen Syndrome, one Long QT Syndrome-type 1 two healthy controls) were generated from peripheral blood obtained donors belonging to the same family. CytoTune™-iPS 2.0 Sendai Reprogramming Kit (containing OCT3/4, KLF4, SOX2 cMYC as reprogramming factors) was used generate all lines. The four iPSCs have normal karyotype, express pluripotency markers determined by RT-PCR flow cytometry differentiated spontaneously in vitro into cells of three...
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disease caused by mutations in genes encoding sarcomere proteins. It the major cause of sudden cardiac death young high-level athletes. Studies have demonstrated a poorer prognosis when associated with specific mutations. The association between HCM genotype and phenotype has been subject several studies since discovery nature disease. This study shows effect MYBPC3 compound variant on phenotypic expression. A family which...
Diabetes mellitus patients (DM) have more severe progression of atherosclerotic disease than non-diabetic (NDM) individuals. In situ inflammation and oxidative stress are key points in the pathophysiology atherosclerosis, a concept largely based on animal model research. There few studies comparing parameters medium-sized arteries between DM NDM patients. A fragment internal mammary artery used coronary bypass grafting (CABG) will be employed for this purpose OBJECTIVE: To assess expression...
Apresentamos casos de coracao atleta, CMH idiopatica e cardiomiopatia armazenamento glicogenio (PRKAG2). Os dois pacientes nao atletas (Pcs) foram submetidos a estudos geneticos biopsias miocardicas. […] Como os Indices Deformacao Ecocardiografica podem Distinguir Diferentes Tipos Hipertrofia Ventricular Esquerda
Aortic diseases arising in Marfan syndrome (MFS), such as aneurysms and dissections of the thoracic aorta, are related to genetic alterations FBN1 gene. Databases, Universal Mutations- , ClinVar, The Human Gene Mutation, contain more than a thousand mutations associated with MFS. gene, which encodes fibrillin-1, is responsible for integral production different protein domains. Possible changes may lead weakening blood vessels, leading development aortopathies. In this study, we present...
Abstract As patient exposure to ionizing radiation from medical imaging and its risks are continuing issues, this study aimed evaluate DNA damage repair markers after myocardial perfusion single-photon emission computed tomography (MPS). Thirty-two patients undergoing Tc-99m sestamibi MPS were studied. Peripheral blood was collected before radiotracer injection at rest 60–90 min injection. The comet assay (single-cell gel electrophoresis) performed with peripheral cells detect strand breaks....
Introduction and objectives: Resistant Hypertension (RH) has a prevalence of 10 to 30%, its pathophysiology been related hyperactivity the Renin-Angiotensin-Aldosterone System, excess circulating aldosterone, activation sympathetic nervous system, arterial stiffness vascular remodeling. Cocoa interesting repercussions on cardiovascular health, improving biochemical parameters, body composition, possibly protecting against DNA damage. This work aimed investigate effect cocoa powder...
Thoracic aortic diseases (or aortopathies) result from complex interactions between genetic and hemodynamic factors. Often clinically silent, these can lead to lethal complications such as dissection or rupture. This study focused on a Brazilian cohort of 79 individuals with thoracic explored factors through targeted next-generation sequencing (tNGS) 15 priority genes FBN1 direct sequencing. The majority had nonsyndromic aortopathy, eight diagnosed Marfan syndrome (MFS). Pathogenic likely...
Mutations in the PRKAG2 gene, which encodes γ2 subunit of AMP-activated protein kinase (AMPK), are linked to a rare cardiomyopathy involving glycogen accumulation, left ventricular hypertrophy, and sudden death. This study investigates novel His401Gln missense mutation gene its effects on AMPK dynamics. Through molecular simulations free energy analyses, we compared AMP ATP binding affinities between wild-type mutant subunits. Structural modeling revealed significant change at site 3 AMPK,...
As patient exposure to ionizing radiation raises concern about malignancy risks, this study evaluated the effect of on patients undergoing myocardial perfusion imaging (MPI) using comet assay, a method for detection DNA damage.Patients without cancer, acute or autoimmune diseases, recent surgery trauma, were studied. Gated single-photon was performed with Tc-99m sestamibi. Peripheral blood collected before radiotracer injection at rest and 60-90 min after injection. Single-cell gel...
Abstract The COVID-19 pandemic had a profound impact on the operation of Brazilian hospital units, even those dedicated to non-infectious diseases. This study aims describe Covid-19 epidemic curve from cardiovascular specialized nosocomial unit. All symptomatic employees were submitted RT-qPCR. A total 613 tests performed 548 between March 23, 2020, and June 4, 2020; with 45.7% positivity samples, representing 11.9% employees. showed drop after first week May. data high contamination rate...
A Tomografia computadorizada por emissão de fóton único perfusão miocárdica ou cintilografia (CPM) é um exame imagem cardíaca não invasivo utilizado para a avaliação do fluxo sanguíneo no tecido miocárdico diagnóstico doenças cardiovasculares. Os pacientes submetidos CPM são avaliados em repouso estresse (físico induzido medicamento). As principais recomendações realizar incluem o doença arterial coronariana (DAC), risco com DAC já diagnosticada, análise da eficácia tratamentos e...
As meningites são processos infecciosos das leptomeninges, cuja gravidade varia de acordo com o agente etiológico, faixa etária e status imunológico do paciente. Essas patologias notificação compulsória fazem parte Condições Sensíveis à Atenção Primária (CSAP), sendo passíveis prevenção por meio da imunização. No calendário vacinal brasileiro, destacam-se as vacinas contra Haemophilus influenzae tipo B, introduzida em 1999, meningococo C conjugada, 2010, além vacina ACWY para adolescentes...
As doenças cardíacas congênitas (DCC) são as anomalias mais frequentes entre recém- -nascidos, com prevalência de 4–10 em 1000 nascidos vivos. Em aproximadamente 70% dos casos DCC ocorrem como malformações isoladas (não-sindrômicas). Postula-se que fatores genéticos desempenham um papel significativo na patogênese das DCC, no entanto, 55% pacientes não se consegue determinar os mecanismos genéticos. Mutações novo causas comuns nas famílias sem herança mendeliana estabelecida. O objetivo...
ABSTRACT Thoracic aortic diseases (or aortopathies) result from complex interactions between genetic and hemodynamic factors. Often clinically silent, these can lead to lethal complications like dissection or rupture. This study focused on a Brazilian cohort of 79 individuals with thoracic diseases, exploring factors through targeted next-generation sequencing (tNGS) 15 priority genes. The majority had non-syndromic aortopathy, eight diagnosed Marfan syndrome (MFS). Pathogenic likely...