A5029026343- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Syncope and Autonomic Disorders
- Congenital heart defects research
- Neurological disorders and treatments
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Metabolism, Diabetes, and Cancer
- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- ECG Monitoring and Analysis
- Acute Ischemic Stroke Management
- Public Health in Brazil
- Pancreatic function and diabetes
- Glycogen Storage Diseases and Myoclonus
- Cardiac Arrest and Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
- Vascular anomalies and interventions
- Venous Thromboembolism Diagnosis and Management
- Pericarditis and Cardiac Tamponade
- Chemotherapy-related skin toxicity
Biocor Institute
2016-2025
Faculdade de Ciências Médicas de Minas Gerais
2012-2024
Mater Dei Hospital
2022-2024
Heart Rhythm Society
2022
Stanford University
2022
Bay Area Community Foundation
2022
João Pinheiro Foundation
2022
Universidad de Extremadura
2021
John Wiley & Sons (United States)
2020
Hudson Institute
2020
Abstract Ventricular arrhythmias are an important cause of morbidity and mortality come in a variety forms, from single premature ventricular complexes to sustained tachycardia fibrillation. Rapid developments have taken place over the past decade our understanding these ability diagnose treat them. The field catheter ablation has progressed with development new methods tools, publication large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook...
Genetic testing has advanced significantly since the publication of 2011 HRS/EHRA Expert Consensus Statement on State Testing for Channelopathies and Cardiomyopathies.1Ackerman M.J. Priori S.G. Willems S. Berul C. Brugada R. Calkins H. et al.European Heart Rhythm Association (EHRA)HRS/EHRA expert consensus statement state genetic channelopathies cardiomyopathies: this document was developed as a partnership between Society (HRS) European (EHRA).Europace. 2011; 13: 1077-1109Crossref PubMed...
Despite significant advances in our understanding of the biology determining systemic energy homeostasis, treatment obesity remains a medical challenge. Activation AMP-activated protein kinase (AMPK) has been proposed as an attractive strategy for and its complications. AMPK is conserved, ubiquitously expressed, heterotrimeric serine/threonine whose short-term activation multiple beneficial metabolic effects. Whether these translate into long-term benefits complications unknown. Here, we...
The anatomic substrates for atrioventricular nodal re-entry remain enigmatic, but require knowledge of the normal arrangement inputs and exist from node. This is crucial to understand phenomenon re-entry.We studied 20 human hearts with serial sections covering entirety triangle Koch cavotricuspid isthmus. We determined location conduction axis connections between specialized cardiomyocytes adjacent working atrial myocardium. node was found at apex Koch, entry central fibrous body providing...
When those carrying out pacing of the His bundle found procedure was able to correct pattern left branch block, they presumed that block consequence discrete lesions in bundle. They further distal a lesion produced normalization QRS complex.1,2 This novel concept dependent on assumption located longitudinally dissociated bundle, ignoring evidence functional lateral connections within which could theoretically circumvent an area conduction block.
AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic exists as αβγ complexes, regulatory γ subunit confers sensor function by binding adenine nucleotides. Humans bearing activating mutations in the γ2 exhibit phenotype including unexplained slowing of heart rate (bradycardia). Here, we show that activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower rate, sarcolemmal hyperpolarization-activated current (I f)...
Introduction: Fasciculoventricular tracts are considered a rare form of ventricular preexcitation. Few fasciculoventricular pathways have been reported, and none linked to reentrant tachycardia. Methods Results: Four patients with bypass underwent electrophysiologic evaluation. Two had single pathway, one that inserted anteroseptally the other in left ventricle. also an AV tract, anterograde conduction over pathway during orthodromic After ablation pathways, ECG sinus rhythm study showed...
To take full advantage of the knowledge cardiac anatomy, structures should be considered in their correct attitudinal orientation. Our aim was to discuss triangle Koch an attitudinally appropriate fashion.We reviewed our material prepared by histological sectioning, along with computed tomographic datasets human hearts. The is right atrial surface inferior pyramidal space, being bordered tendon Todaro and hinge septal leaflet tricuspid valve, its base at cavotricuspid isthmus. fibro-adipose...
Background— Epicardial mapping and ablation of accessory pathways through a subxiphoid approach can be an alternative when endocardial or epicardial transvenous has failed. Methods Results— We reviewed acute long-term follow-up 21 patients (14 males) referred for percutaneous pathway ablation. There was median 2 previous failed procedures. All were highly symptomatic, 8 had atrial fibrillation (3 with cardiac arrest) 13 frequent symptomatic episodes atrioventricular reentrant tachycardia....
It is almost 100 years ago since Mahaim described the so-called paraspecific connections between ventricular conduction axis and crest of muscular septum, believing such pathways to be ubiquitous. These pathways, however, have yet considered as potential for septal activation during His bundle pacing.So explore hypothesis that specialised might provide substrate pacing, we compared findings from 22 serially sectioned histological datasets 34 different individuals undergoing pacing.We found...
Automatic rhythms associated with Mahaim fibers usually occur during radiofrequency catheter ablation. The incidence and significance of spontaneous automaticity in are unknown.Spontaneous automatic were observed 5 (12.5%) 40 patients referred for nonpharmacologic therapy because recurrent episodes symptomatic tachyarrhythmias, antidromic circus movement tachycardia (33/40 patients). Three female two male. Their mean age was 15 +/- 7 years compared to 26 13 the without (P = 0.09). had both...
The clinical characteristics of atrial tachycardias (AT) ablated from the non-coronary aortic sinus (NCS) are thus far described only in small series. We aimed to outline, a large cohort patients, clinical, electrocardiographic, electrophysiological this tachycardia. analysed data pertaining and 43 consecutive patients an overall 441 with AT who were successfully NCS. NCS paroxysmal (98%) adenosine sensitive (35/35). aged 54.6 ± 12.4 years, showing female preponderance (74%). No P wave...
Seeking to account for accessory atrioventricular conduction potentially leading ventricular pre-excitation, Mahaim in the mid-20th century had described pathways between axis and muscular septum. We aimed look such 'paraspecific' connections adult human hearts.We serially sectioned 21 hearts, covering triangle of Koch aortic root, assessing node, penetration axis, bundle branches our search fasciculo-ventricular connections. also calculated length non-branching bundle, if present origin The...
Short A-V manheim fiber.A short atrioventricular decrementally conducting accessory pathway is an uncommon variant of preexcitation. Available data from small series suggest that their decremental properties might not be caused by nodal-like tissue.We compared clinical, electrocardiographic and electrophysiologic parameters in two groups patients: 8 patients with a Mahaim (Group A), 33 atriofascicular pathways B). Radiofrequency catheter ablation was carried out guided activation mapping at...