A5062809850- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Calcium signaling and nucleotide metabolism
- Traditional Chinese Medicine Studies
- Cardiac pacing and defibrillation studies
- Carbon and Quantum Dots Applications
- Electrochemical Analysis and Applications
- Insect-Plant Interactions and Control
- Insect and Pesticide Research
- Biosimilars and Bioanalytical Methods
- stochastic dynamics and bifurcation
- Pancreatic function and diabetes
- Pharmacological Effects of Natural Compounds
- Insect Resistance and Genetics
- Metabolism, Diabetes, and Cancer
- Piperaceae Chemical and Biological Studies
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Cardiac Arrhythmias and Treatments
- Lysosomal Storage Disorders Research
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
Axxam (Italy)
2020-2024
University of Milan
2014-2022
Centre Universitaire de Mila
2021
Aims Inappropriate Sinus Tachycardia (IST), a syndrome characterized by abnormally fast sinus rates and multisystem symptoms, is still poorly understood. Because of the relevance HCN4 channels to pacemaker activity, we used candidate-gene approach screened IST patients for presence disease-causing mutations. Methods results Forty-eight patients, four whom known familial history, were enrolled in study. We initially identified one with history R524Q mutation HCN4. Investigation extended...
AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic exists as αβγ complexes, regulatory γ subunit confers sensor function by binding adenine nucleotides. Humans bearing activating mutations in the γ2 exhibit phenotype including unexplained slowing of heart rate (bradycardia). Here, we show that activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower rate, sarcolemmal hyperpolarization-activated current (I f)...
Hyperpolarization-activated and cyclic-nucleotide-gated 1 (HCN1) ion channels are proposed to be critical for cognitive function through regulation of synaptic integration. However, resolving the precise role HCN1 in neurophysiology exploiting its therapeutic potential has been hampered by minimally selective antagonists with poor potency limited vivo efficiency. Using automated electrophysiology a small-molecule library screen chemical optimization, we identified primary carboxamide series...
Tongmai Yangxin (TMYX) is a complex compound of the Traditional Chinese Medicine (TCM) used to treat several cardiac rhythm disorders; however, no information regarding its mechanism action available. In this study we provide detailed characterization effects TMYX on electrical activity pacemaker cells and unravel action. Single-cell electrophysiology revealed that elicits reversible dose-dependent (2/6 mg/ml) slowing spontaneous potentials rate (−20.8/–50.2%) by selective reduction...
Abstract Tongmai Yangxin (TMYX), is a complex compound of Traditional Chinese Medicine (TCM) used to treat several cardiac rhythm disorders; however, no information regarding its mechanism action available. In this study we provide detailed characterization the effects TMYX on electrical activity pacemaker cells and unravel action. Single-cell electrophysiology revealed that elicits reversible dose-dependent (2/6 mg/ml) slowing spontaneous potentials rate (−20.8/-50.2%) by selective...