A5075006748- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Digestive system and related health
- Cardiovascular Effects of Exercise
- Diet, Metabolism, and Disease
- Muscle Physiology and Disorders
- COVID-19 Clinical Research Studies
- Oral and gingival health research
- Cardiac Valve Diseases and Treatments
- Renin-Angiotensin System Studies
- Cardiovascular Issues in Pregnancy
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Parathyroid Disorders and Treatments
- Pharmacological Effects of Natural Compounds
- Cardiac Imaging and Diagnostics
- Adenosine and Purinergic Signaling
- Vitamin C and Antioxidants Research
- Long-Term Effects of COVID-19
- RNA Research and Splicing
- Viral Infections and Immunology Research
- Cardiac Fibrosis and Remodeling
- Calcium signaling and nucleotide metabolism
Uppsala University Hospital
2020-2024
Uppsala University
2019-2024
University of Oxford
2010-2017
Oxford Centre for Mission Studies
2014
National University College
2012
Seoul National University
2012
Imperial College London
2012
University of Wisconsin–Madison
2012
University of Birmingham
2011
Contractor UK
2011
The citric acid cycle (CAC) metabolite fumarate has been proposed to be cardioprotective; however, its mechanisms of action remain determined. To augment cardiac levels and assess fumarate's cardioprotective properties, we generated hydratase (Fh1) knockout (KO) mice. These fumarate-replete hearts were robustly protected from ischemia-reperfusion injury (I/R). compensate for the loss Fh1 activity, KO maintain ATP in part by channeling amino acids into CAC. In addition, stabilizing...
Patients undergoing aortic valve replacement for critical stenosis often have significant left ventricular hypertrophy. Left hypertrophy has been identified as an independent predictor of poor outcome after a result combination maladaptive myocardial changes and inadequate protection at the time surgery. Glucose-insulin-potassium (GIK) is potentially useful adjunct to protection. This study was designed evaluate effects GIK infusion in patients surgery.Patients with evidence were randomly...
AMP-activated protein kinase (AMPK) is an important regulator of energy balance and signaling in the heart. Mutations affecting regulatory γ2 subunit have been shown to cause essentially cardiac-restricted phenotype hypertrophy conduction disease, suggesting a specific role for this
To explore the early effects of dapagliflozin on myocardial function and metabolism in patients with type 2 diabetes without heart failure.Patients metformin treatment were randomized to double-blind, 6-week placebo or 10 mg daily treatment. Investigations included cardiac structure resonance imaging; oxygen consumption, perfusion efficiency [11 C]-acetate positron emission tomography (PET); hepatic fatty acid uptake [18 F]-6-thia-heptadecanoic PET, analysed by ANCOVA as least square means...
AMPK is a conserved serine/threonine kinase whose activity maintains cellular energy homeostasis. Eukaryotic exists as αβγ complexes, regulatory γ subunit confers sensor function by binding adenine nucleotides. Humans bearing activating mutations in the γ2 exhibit phenotype including unexplained slowing of heart rate (bradycardia). Here, we show that activation downregulates fundamental sinoatrial cell pacemaker mechanisms to lower rate, sarcolemmal hyperpolarization-activated current (I f)...
Abstract Titin truncating variants are a well-established cause of cardiomyopathy; however, the role titin missense is less well understood. Here we describe generation mouse model to investigate underlying disease mechanism previously reported A178D variant identified in family with non-compaction and dilated cardiomyopathy. Heterozygous homozygous mice carrying were characterised vivo by echocardiography. had no detectable phenotype at any time point investigated (up 1 year). By contrast,...
OBJECTIVE The aim of this study was to investigate the impact sodium–glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin on tissue fatty acid (FA) uptake in skeletal muscle, brain, small intestine, and subcutaneous visceral adipose individuals with type diabetes by using positron emission tomography (PET). RESEARCH DESIGN AND METHODS In a 6-week randomized double-blind placebo-controlled trial, 53 patients treated metformin received either 10 mg or placebo daily. Tissue FA quantified at...
<p dir="ltr">Objective: The aim of this study was to investigate the impact sodium-glucose transporter 2 inhibitor dapagliflozin on tissue fatty acid (FA) uptake in skeletal muscle, brain, small intestine, and subcutaneous visceral adipose people with type diabetes by using positron emission tomography (PET).</p><p dir="ltr">Research Design Methods: In a 6-week randomized, double-blinded, placebo-controlled trial, 53 patients treated metformin received either 10 mg or...
<p dir="ltr">Objective: The aim of this study was to investigate the impact sodium-glucose transporter 2 inhibitor dapagliflozin on tissue fatty acid (FA) uptake in skeletal muscle, brain, small intestine, and subcutaneous visceral adipose people with type diabetes by using positron emission tomography (PET).</p><p dir="ltr">Research Design Methods: In a 6-week randomized, double-blinded, placebo-controlled trial, 53 patients treated metformin received either 10 mg or...
To maximize data obtainment from valuable cardiac tissue, we hypothesized that myocardium fixed in optimal cutting temperature (OCT) medium for histology could also be used to investigate the function of myofilament proteins situ. We compared tissue prepared via conventional liquid nitrogen (LN) snap freezing with OCT and then sectioned fiber-parallel orientation. found actin-myosin Ca2+ sensitivity, activation rate by Ca2+, cooperativity along thin filament, as well cross-bridge cycling...
Study objective: We have found different survival rates in response to a 4-day angiotensin II (AngII) and high salt diet - treatment two mouse strains, BalbC/J C57BL6/J. The mortality is increased mice alongside lung weight but the reason unknown. Hypothesis: hypothesize due differences myocardial compliance. Methodology: Male were treated with AngII by osmotic mini-pump infusion fed salt-diet (3%) for 4 days. At end of lungs weighed. Left ventricle (LV) passive compliance was assessed...
ABSTRACT Objective We aimed to investigate cardiac effects of severe SARS-CoV-2 and the importance echocardiography-assessment biomarkers. Methods This is an observational study first patients admitted intensive care due SARS-CoV-2-respiratory failure. Thirty-four underwent echocardiography which twenty-five were included, compared forty-four non-echo patients. Exclusion was based on absence normofrequent sinus rhythm and/or mechanical respiratory support. Biomarkers analysed clinical...