A5101611395- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Biochemical and Structural Characterization
- Protein Structure and Dynamics
- Antimicrobial Peptides and Activities
- Genetics, Bioinformatics, and Biomedical Research
- Computational Drug Discovery Methods
- Childhood Cancer Survivors' Quality of Life
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Ion channel regulation and function
- Cell Adhesion Molecules Research
- Neurobiology and Insect Physiology Research
- Plant Gene Expression Analysis
- Receptor Mechanisms and Signaling
- Plant Stress Responses and Tolerance
- Insect and Pesticide Research
- Aquaculture disease management and microbiota
- Machine Learning in Bioinformatics
- Aquaculture Nutrition and Growth
- Transgenic Plants and Applications
- FinTech, Crowdfunding, Digital Finance
- Cell death mechanisms and regulation
- Heat shock proteins research
- Cancer, Hypoxia, and Metabolism
State University of Norte Fluminense
2009-2022
Boston Children's Hospital
2020
Dana-Farber Cancer Institute
2015-2020
Harvard University
2015
Prefeitura Municipal de Campos dos Goytacazes
2011
Laboratório Nacional de Computação Científica
2007-2011
Instituto Butantan
2003-2005
Universidade Estadual de Campinas (UNICAMP)
2005
Brazilian Agricultural Research Corporation
2003
Lectins are glycan-binding receptors that recognize glycan epitopes on foreign pathogens and in the host systems. They can be involved functions include innate immunity, development, immune regulation homeostasis. Several lectins have been purified characterized from fish species. In this work, using cation-exchange chromatography, a galactose-specific lectin belonging to family of C-type was isolated venom Brazilian venomous Thalassophryne nattereri. Nattectin is basic, non-glycosilated, 15...
The COVID-19 pandemic has had an unprecedented impact on the global economy and public health. Its etiologic agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible, pathogenic a rapid spread. Currently, increase in number of new confirmed cases been slowed down due to vaccination some regions world. Still, rise variants influenced detection additional waves rising that countries have experienced. Since virus replication cycle composed many distinct...
The efficacy and safety of two whole IgG polyvalent antivenoms (A B) were compared in a randomised, blinded clinical trial 67 patients systemically envenomed by Bothrops asper Colombia. Both fractionated caprylic acid precipitation had similar neutralising potencies, protein concentrations aggregate contents. Antivenom B was additionally treated with β-propiolactone to lower its anticomplementary activity. Analysing all treatment regimens together, there no significant differences between...
Background Treatment‐related mortality and abandonment of therapy are major barriers to successful treatment childhood acute lymphoblastic leukemia (ALL) in the developing world. Procedure A collaboration was undertaken between Instituto Nacional de Cancerologia (Bogota, Colombia), which serves a poor patient population an upper‐middle income country, Dana‐Farber/Boston Children's Cancer Blood Disorders Center (Boston, USA). Several interventions aimed at reducing toxic deaths were...
Brazilian freshwater stingrays, Potamotrygon gr. orbigyni, are relatively common in the middle-western regions of Brazil, where they considered an important public health threat. In order to identify some their naturally occurring toxin peptides available very low amounts, we combine analytical protocols such as reversed-phase high-performance liquid chromatography (RP-HPLC), followed by a biological microcirculatory screening and mass spectrometry analysis. Using this approach, one...
Aluminum (Al) toxicity induces changes in the expression of several genes, some which are involved plant responses to oxidative stress. Using mRNA differential display, we identified a maize Al-inducible cDNA encoding glutathione S-transferase (GST). The gene was named GST27.2 owing its homology GST27, is known be induced by xenobiotics. present genome as single copy and analysis pattern revealed that expressed mainly root tip. Expression up-regulated response various Al Cd concentrations...
Introduction. Scorpion stings are a public health problem in many countries. However, Colombia, very few epidemiological, clinical or toxicological studies have been undertaken.Objective. Ecological and epidemiological aspects were related to the prevalence of scorpion by Tityus asthenes. The features envenomization described patients an experimental animal model.Materials methods. study was conducted four localities Mutatá Urabá Counties province Antioquia, Colombia. sample consisted 1,593...
Stresses such as cold and drought can impair plant yield induce a highly complex array of responses. Sugarcane (Saccharum spp.) is cultivated in tropical subtropical areas considered cold-sensitive plant. We previously showed that stress induces the expression several genes vitro sugarcane plantlets. Here we characterize one those genes, SsNAC23, member NAC family plant-specific transcription factors, which are induced by low temperature other stresses species. The SsNAC23 was plants exposed...
The major Ricinus communis allergens are the 2S albumins, Ric c 1 and 3. These proteins contain a trypsin/α-amylase inhibitor family domain, suggesting that they have role in insect resistance. In this study, we verified 3 inhibited α-amylase activity of Callosobruchus maculatus, Zabrotes subfasciatus, Tenebrio molitor (TMA) larvae as well mammalian α-amylase. toxicity albumin was determined through its incorporation C. maculatus part an artificial diet. Bioassays revealed reduced larval...
Macrophages are essential components of the innate and adaptive immune responses, playing a decisive role in atherosclerosis, asthma, obesity, cancer.The differential gene expression resulting from adhesion macrophages to extra-cellular matrix (ECM) has been studied J774A1 murine macrophage cell line using quantitative polymerase chain reaction (qPCR).The goal this study was identify housekeeping genes (HKGs) that remain stable unaltered under normal culture conditions presence laminin after...
Abstract Background The Structural Descriptor Database (SDDB) is a web-based tool that predicts the function of proteins and functional site positions based on structural properties related protein families. alignments residues known set (defined as training set) are used to build special Hidden Markov Models (HMM) called HMM descriptors. SDDB uses previously calculated stored descriptors for predicting active sites, binding residues, function. database integrates biologically relevant data...
Abstract In order to investigate the relationship between primary structure of Orpotrin, a vasoactive peptide previously isolated from freshwater stingray Potamotrygon gr. orbignyi , and its microcirculatory effects, three Orpotrin analogs were synthesized. The have truncated N ‐terminal with His residue deletion two substituted amino acid residues, where one Nle is for internal Lys third analog has substitution Pro an Ala (Orp‐desH 1 Orp‐Nle Orp‐Pro/Ala, respectively). Only Orp‐desH could...
The recent discoveries of Neptune-sized ultra-short period planets (USPs) challenge existing planet formation theories. It is unclear whether these residents the Hot Neptune Desert have similar origins to smaller, rocky USPs, or if this discrete population evidence a different pathway altogether. We report discovery TOI-3261b, an ultra-hot with orbital $P$ = 0.88 days. host star $V 13.2$ magnitude, slightly super-solar metallicity ([Fe/H] $\simeq$ 0.15), inactive K1.5 main sequence at $d...