Po-Yen Chen

ORCID: 0000-0002-7250-2478
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About
Contact & Profiles
Research Areas
  • Pneumonia and Respiratory Infections
  • Respiratory viral infections research
  • Streptococcal Infections and Treatments
  • Antimicrobial Resistance in Staphylococcus
  • Urinary Bladder and Prostate Research
  • Viral gastroenteritis research and epidemiology
  • nanoparticles nucleation surface interactions
  • High Entropy Alloys Studies
  • Advanced Materials Characterization Techniques
  • Virology and Viral Diseases
  • Viral Infections and Immunology Research
  • Viral Infections and Vectors
  • Pelvic floor disorders treatments
  • Prostate Cancer Treatment and Research
  • COVID-19 Clinical Research Studies
  • Influenza Virus Research Studies
  • Bladder and Urothelial Cancer Treatments
  • Prostate Cancer Diagnosis and Treatment
  • Mosquito-borne diseases and control
  • Vaccine Coverage and Hesitancy
  • SARS-CoV-2 and COVID-19 Research
  • Urological Disorders and Treatments
  • Membrane-based Ion Separation Techniques
  • Minimally Invasive Surgical Techniques
  • Hematopoietic Stem Cell Transplantation

Taichung Veterans General Hospital
2012-2025

Delta Electronics (Taiwan)
2024

Kaohsiung Chang Gung Memorial Hospital
2017-2024

National Chung Hsing University
2009-2023

National Taipei University
2023

National Tsing Hua University
2023

Chang Gung University
2002-2022

Chang Gung Memorial Hospital
2022

Shu-Te University
2022

Taipei Medical University
2020

10.1016/j.jmii.2020.02.011 article cc-by-nc-nd Journal of Microbiology Immunology and Infection 2020-02-25

In 1998, an enterovirus 71 (EV71) epidemic in Taiwan was associated with hand, foot, and mouth disease (HFMD)/herpangina involved 78 fatal cases. We measured EV71 seroprevalence rates before after the investigated risk factors infection illness.Neutralizing antibodies to were assayed for 539 people 4619 of similar ages epidemic. Questionnaires, which completed during household interviews epidemic, solicited demographic variables, exposure history, clinical manifestations.A total 129 106...

10.1542/peds.109.6.e88 article EN PEDIATRICS 2002-06-01

We reported two cases with community-acquired pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who returned from Wuhan, China in January, 2020. The highlight non-specific clinical presentations of 2019 novel disease (COVID-19) as well the importance rapid laboratory-based diagnosis.

10.1016/j.jmii.2020.02.009 article EN cc-by-nc-nd Journal of Microbiology Immunology and Infection 2020-02-19

Methicillin-resistant Staphylococcus aureus (MRSA) has been identified as a major cause of community-associated (CA) S. infections in the past decade. The main reservoir community for MRSA and factors contributing to its worldwide spread remain poorly defined. Between July 2005 June 2008, total 6,057 healthy children 2 60 months age were screened carriage Streptococcus pneumoniae Taiwan. prevalence epidemiological influencing determined. strains tested antimicrobial susceptibility underwent...

10.1128/jcm.01774-10 article EN Journal of Clinical Microbiology 2010-11-18

From July 2005 to October 2006, a total of 3,046 children, ages between 2 months and 5 years, presented for well-child health care visit one three medical centers, which are located in the northern, central, southern parts Taiwan, were surveyed nasal carriage methicillin-resistant Staphylococcus aureus (MRSA). The overall prevalences S. MRSA among children 23% 7.3%, respectively (18% 4.8% central region, 25% 6.7% 27% 9.5% northern region). Of 212 isolates (96%) available analysis, 10...

10.1128/jcm.01202-07 article EN Journal of Clinical Microbiology 2007-10-18

Fever of unknown origin (FUO) can be caused by many clinical conditions and remains a diagnostic challenge in practice. The etiology FUO varies markedly among different age groups, geographic areas, seasons. A four-stage investigative protocol for is widely applied aim this study was to evaluate the usefulness identifying children. We enrolled children younger than 18 years who were admitted Taichung Veterans General Hospital during period from January 2006 December 2014 with persisting more...

10.1016/j.jmii.2015.08.007 article EN cc-by-nc-nd Journal of Microbiology Immunology and Infection 2015-10-21

A laboratory-based surveillance network of 11 clinical virological laboratories for influenza viruses was established in Taiwan under the coordination Center Disease Control and Prevention (CDC), Taiwan. From October 2000 to March 2004, 3,244 were isolated, including 1,969 1,275 B viruses. The infections usually occurred frequently winter northern hemisphere. However, seasonality not clear during four seasons investigation. For example, peaked winters 2001, 2002, 2003. some isolated peaks...

10.1128/jcm.43.4.1651-1661.2005 article EN Journal of Clinical Microbiology 2005-04-01

The information of molecular characteristics and antimicrobial susceptibility pattern methicillin-resistant Staphylococcus aureus (MRSA) is essential for control treatment diseases caused by this medically important pathogen. A total 577 clinical MRSA bloodstream isolates from six major hospitals in Taiwan were determined types, carriage Panton-Valentine leukocidin (PVL) sasX genes susceptibilities to 9 non-beta-lactam agents. 17 genotypes identified strains pulsotyping. Five pulsotypes,...

10.1371/journal.pone.0101184 article EN cc-by PLoS ONE 2014-06-26

ABSTRACT During July 2000 and October 2001, a total of 595 clinical isolates methicillin-resistant Staphylococcus aureus (MRSA) were collected from six medical centers distributed in northern, central, southern Taiwan. Specimen sources included blood ( n = 279), pus 173), sputum 94), body fluids 21), catheter tips 20), urine 8). Pulsed-field gel electrophoresis (PFGE) with Sma I digestion was used to fingerprint these isolates. A 31 genotypes 97 type-subtypes identified. Subtypes could be...

10.1128/jcm.42.1.307-310.2004 article EN Journal of Clinical Microbiology 2004-01-01

In recent years, there has been a gradual increase in the prevalence of drug-resistant bacteria, primarily attributed to widespread use antibiotics. This resulted heightened mortality rates, morbidity, and exorbitant healthcare costs associated with antibiotic-resistant bacterial infections. order mitigate spread environmental disinfection plays crucial role. Ultraviolet radiation C (UVC) light emerged as potent technique limit transmission nosocomial pathogens prevent healthcare-associated...

10.1128/spectrum.04251-23 article EN cc-by Microbiology Spectrum 2024-10-25

The aim of the study was to investigate whether 7-valent pneumococcal conjugate vaccine (PCV7) alters common risk factors nasopharyngeal carriage by Streptococcus pneumoniae in children.From July 2005 through December 2010, we performed a cross-sectional investigating associated with children. Parents participating children completed questionnaires including or not received PCV7 vaccination.Among 9705 children, 20.2% them at least 1 dose vaccine. Multivariate logistic regression models...

10.1097/inf.0b013e31825cb9f9 article EN The Pediatric Infectious Disease Journal 2012-05-16

Japanese encephalitis (JE) is the most important cause of viral in Asia. In this randomized, open-label, multicenter trial 550 children aged 12 to 18 months Taiwan, received one dose JE-CV and MMR vaccine. Vaccines were either administered separately 6 weeks apart (Groups ‘JE-CV’ ‘MMR’, named after which vaccine was given first), or concomitantly (Group ‘Co-Ad’). JE neutralizing antibody titers assessed using PRNT50. levels determined by ELISA. All groups had low...

10.1016/j.vaccine.2014.02.085 article EN cc-by-nc-sa Vaccine 2014-03-15

Mammalian aquaporin 1 (AQP1) is well known to function as a membrane channel for H2O and CO2 transport. Zebrafish AQP1a.1 (the homologue of mammalian AQP1) was recently identified in ionocytes embryos; however its role still unclear. In this study, we hypothesized that zebrafish involved the acid secretion by through facilitating diffusion. A real-time PCR showed mRNA levels embryos were induced exposure 1% hypercapnia 3 days. situ hybridization immunohistochemistry transcript highly...

10.1371/journal.pone.0136440 article EN cc-by PLoS ONE 2015-08-19

Staphylococcus aureus (S. aureus) causes diseases ranging from mild skin infections to invasive diseases. Carriage of S. aureus, including methicillin-resistant (MRSA), is a significant risk factor for subsequent staphylococcal infection. Several studies discussed MRSA colonization in Taiwan, but mostly northern Taiwan. This the first study that estimates prevalence nasal healthy children and identifies potential factors central Taiwan.A total 3144 aged 2-60 months who visited Taichung...

10.1016/j.jmii.2016.08.020 article EN cc-by-nc-nd Journal of Microbiology Immunology and Infection 2017-06-22
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