We reported two cases with community-acquired pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who returned from Wuhan, China in January, 2020. The highlight non-specific clinical presentations of 2019 novel disease (COVID-19) as well the importance rapid laboratory-based diagnosis.

Delafloxacin is an investigational anionic fluoroquinolone antibiotic with broad-spectrum in vitro activity, including activity against Gram-positive organisms, Gram-negative atypical and anaerobes. The of delafloxacin the percent microbiological response subjects infected fluoroquinolone-susceptible nonsusceptible Staphylococcus aureus isolates were determined from two global phase 3 studies versus vancomycin plus aztreonam patients acute bacterial skin structure infections (ABSSSI)....

The emergence of carbapenem-resistant Klebsiella pneumoniae poses a significant threat to public health. In this study, we aimed investigate the distribution and genetic diversity plasmids carrying beta-lactamase resistance determinants in collection K. blood isolates. Blood isolates bacteremia were collected identified. Whole-genome sequencing, assembly analysis performed for prediction antimicrobial determinants. Plasmidome was also performed. Our plasmidome revealed two major plasmid...

Ceftazidime-avibactam (CAZ-AVI) has been launched in Asian countries for five years, but local real-world data about patient characteristics, efficacy, and safety of CAZ-AVI is limited. We conducted a multicenter, retrospective study to investigate the clinical microbiology, outcomes patients treated with Gram-negative bacterial infection Taiwan. This investigation was as multicenter cohort involving medical centers Adult documented/suspected received ≥ 24 hours were eligible enrollment....

This study aimed to develop an early prediction model for identifying patients with bloodstream infections. The data resource was taken from 2015 2019 at Taichung Veterans General Hospital, and a total of 1647 infection episodes 3552 non-bloodstream in the intensive care unit (ICU) were included development evaluation. During analysis, 30 clinical variables selected, including patients’ basic characteristics, vital signs, laboratory data, information. Five machine learning algorithms applied...

Abstract Atrial fibrillation (AF) is an important complication of acute myocardial infarction (AMI). The association between AF and serum lipid profile unclear statin use for lowering the incidence new-onset remains controversial. objective this study was to investigate whether statins confer a beneficial effect on after AMI. Data available in Taiwan National Health Insurance Research Database 32886 AMI patients 2008 2011 were retrospectively analyzed. Total 27553 (83.8%) had complete 1-yr...

(1) Background: Elizabethkingia spp. is an emerging nosocomial pathogen which causes mostly blood stream infection and pneumonia. Among species, anophelis the major pathogen, but misidentification as meningoseptica a common problem. also possesses broad antibiotic resistance, resulting in high morbidity mortality of infection. The aim our study was to review intra-abdominal infections investigate resistance mechanisms against TMP/SMX by whole genome sequencing. (2) Methods: We...

Background and Objectives: Actinomyces species are part of the normal flora humans rarely cause disease. It is an uncommon disease in humans. The clinical features actinomycosis have been described, various anatomical sites (such as face, bones joints, respiratory tract, genitourinary digestive central nervous system, skin, soft tissue structures) can be affected. not easy to identify because it sometimes mimics cancer due under-recognition. As new diagnostic methods applied, now more easily...

Type 2 diabetes was associated with a higher risk for permanent pacemaker (PPM) treatment. The difference in cardiovascular outcomes between patients and without receiving PPM treatment remains unexplored.Between January 2003 December 2017, 1742 naïve comprised this retrospective cohort study were categorized into two groups by the diagnosis of diabetes: group (n = 632, 36.3%) 1110, 63.7%). primary outcome events including heart failure (HF) hospitalization acute myocardial infarction (AMI)....

Few studies have investigated the clinical efficacy and pulmonary side effects of different P2Y12 inhibitors in acute coronary syndrome (ACS) patients. The aim this study was to explore impact forced expiratory volume 1 second over vital capacity (FEV1/FVC) ratio on outcomes ACS patients treated with dual antiplatelet therapy after percutaneous intervention (PCI).ACS who underwent PCI, had documented pre-existing spirometry tests, received aspirin either ticagrelor or clopidogrel were...

Background/Aim: Identifying pathogens with culture-negative pyogenic spondylitis is difficult. Shotgun metagenomic sequencing an unbiased and culture-free approach in the diagnosis of infectious diseases. There are, however, a variety contaminating factors that can confound precision sequencing. Case Report: In 65-year-old man suffering from L3-5 spondylitis, metagenomics was applied to facilitate diagnosis. The patient underwent percutaneous endoscopic lumbar discectomy. We robust...

Naja atra bites cause severe soft tissue injury and are prone to wound infections. The pathogens of bite-wound infections highly variable in different geographical regions. Here, we report the first coinfection with Shewanella algae Morganella morganii from a bite resistome analysis using whole genome sequencing.

Use of statistical models for assessing the clinical risk readmission to medical and surgical intensive care units is well established. However, predicting coronary unit (CCU) are rarely reported. Therefore, this study investigated characteristics outcomes patients readmitted CCU identify factors establish a scoring system identifying at high readmission.Medical data were collected 27,841 with history single multi-center healthcare provider in Taiwan during 2001-2019. Characteristics...

Shewanella algae is a zoonotic pathogen that poses serious health threat to immunocompromised hosts. Treatment of S. infections challenging due the pathogen's intrinsic resistance variety β-lactam antibiotics. Therapeutic options have become further limited by emergence quinolone-resistant strains. Currently, there are few studies concerning genetic and molecular mechanisms underlying acquired quinolones in algae. qnrA was once proposed as candidate gene related However, recent demonstrated...

Coinfection in COVID-19 patients is associated with worsening outcome. Among COVID-19, Legionella pneumophila, a common cause of pneumonia, has been reported as co-occurring respiratory infection. A nonspecific clinical presentation, however, makes an early diagnosis difficult. Bronchoalveolar lavage fluid was collected from patient suffering and presenting pneumonia sent for metagenomic analysis. Differential abundance analysis carried out by comparing each taxon reads per million between...

Purpose: The COVID-19 pandemic poses a serious threat to healthcare workers and hospitalized patients. Early detection of cases is essential control the spread in facilities. However, real-world data on screening criteria for patients remain scarce. We aimed explore whether with negative results pre-hospital should be rescreened after admission low-prevalence (less than 3% world average) setting. Patients Methods: retrospectively included central Taiwan who were at first but newly diagnosed...

Introduction: Cardiovascular disease is one of the leading causes mortality worldwide. Acute myocardial infarction (AMI) associated with weather change. The study aimed to investigate if change was among risk factors coronary artery influence AMI occurrence in Taiwan and generate a model predict probabilities specific clinical conditions. Method: This observational utilized National Health Insurance Research Database daily reports from Central Weather Bureau evaluate discharge records...

Accurate diagnosis of chronic, non-healing wounds is challenging and time-consuming because it can be caused by a variety etiologies. This brief report presents an unusual case chronic wound lasting for 10 months investigated deep metagenomic sequencing. Epstein-Barr virus (EBV) was identified in the subsequently validated situ hybridization. Histopathologic examination eventually revealed that due to EBV-associated NK/T cell lymphoma. By identifying mutations across viral genome, classified...

Background Cancer and diabetes are risk factors for COVID-19 mortality rates. Remdesivir, dexamethasone, vaccines used to improve clinical outcomes. We aimed evaluate the associated with Methods This retrospective study enrolled moderate critical patients. The index day was of diagnosis. Patients were followed up until either death or discharge. A two-way analysis variance examined interaction between independent factors. Results total 205 patients analyzed, rate 29.5% (n=60/205). cumulative...

CRISPR-Cas systems are adaptive immune mechanisms present in most prokaryotes that play an important role the adaptation of bacteria and archaea to new environments. Shewanella algae is a marine zoonotic pathogen with worldwide distribution, which accounts for majority clinical cases infections. However, characterization has not been well investigated yet. Through whole genome sequence analysis, we characterized S. algae. Our results indicate prevalent algae, strains containing Type I-F...