A5038625593- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- Bacterial Genetics and Biotechnology
- Bone and Dental Protein Studies
- Lipid metabolism and disorders
- Platelet Disorders and Treatments
- Streptococcal Infections and Treatments
- Oral microbiology and periodontitis research
- Cancer therapeutics and mechanisms
- Cytokine Signaling Pathways and Interactions
- Antibiotic Use and Resistance
- Glycosylation and Glycoproteins Research
- X-ray Diffraction in Crystallography
- Pharmacological Effects of Natural Compounds
- Burkholderia infections and melioidosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Crystallization and Solubility Studies
- Probiotics and Fermented Foods
- Bacterial biofilms and quorum sensing
- Chemical Looping and Thermochemical Processes
- Phenothiazines and Benzothiazines Synthesis and Activities
- Dental Erosion and Treatment
Melinta Therapeutics (United States)
2016-2023
Pfizer (United States)
2003-2017
Allergan (Taiwan)
2015
Cubist Pharmaceuticals (United States)
2013
Rush University Medical Center
2010
Stanford University
2003
Institut thématique Immunologie, inflammation, infectiologie et microbiologie
2002
UConn Health
1990-1993
University of Connecticut
1992
Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target clinical immunosuppression. We report the development a specific, orally active inhibitor JAK3, CP-690,550, that significantly prolonged survival in murine model heart transplantation and cynomolgus monkeys receiving kidney transplants. CP-690,550 treatment was not associated with hypertension, hyperlipidemia, or lymphoproliferative disease. On basis these preclinical results, we...
When challenged with extracellular ATP, leukocytes respond and activate processes attributed to the P2X(7) receptor (P2X(7)R), an unusual ligand-gated ion channel. To prove P2X(7)R involvement, blood samples from P2X(7)R-deficient mice were characterized. Monocytes lymphocytes associated wild-type responded ATP underwent volume/shape changes shed L-selectin. In contrast, animals demonstrated no change in physical properties or L-selectin expression following challenge. Blood stimulated LPS...
There is a critical need for safer and more convenient treatments organ transplant rejection autoimmune disorders such as rheumatoid arthritis. Janus tyrosine kinases (JAK1, JAK3) are expressed in lymphoid cells involved the signaling of multiple cytokines important various T cell functions. Blockade JAK1/JAK3-STAT pathway with small molecule was anticipated to provide therapeutic immunosuppression/immunomodulation. The Pfizer compound library screened against catalytic domain JAK3 resulting...
We report a multicity outbreak of cfr-containing linezolid-resistant Staphylococcus epidermidis in Ohio. Thirty-nine isolates were obtained from 2 hospitals. Two clones with different mechanisms linezolid resistance circulating hospital A. One these contained the cfr gene, and other ribosomal mutation. The clone containing was identical both
Delafloxacin is an investigational anionic fluoroquinolone antibiotic with broad-spectrum in vitro activity, including activity against Gram-positive organisms, Gram-negative atypical and anaerobes. The of delafloxacin the percent microbiological response subjects infected fluoroquinolone-susceptible nonsusceptible Staphylococcus aureus isolates were determined from two global phase 3 studies versus vancomycin plus aztreonam patients acute bacterial skin structure infections (ABSSSI)....
Herein we describe the structure-aided design and synthesis of a series pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa , Klebsiella pneumoniae Escherichia coli . Rat pharmacokinetic studies compound 17 demonstrate low clearance plasma protein binding. In addition, evidence is provided for number suggesting that siderophore receptors PiuA PirA play role drug uptake P. strain PAO1.
We describe the investigation and control of a Klebsiella pneumoniae carbapenemase-producing K. outbreak in 20-bed surgical intensive care unit during period from January 1, 2009 through 2010. Nine patients were either colonized or infected with monoclonal strain pneumoniae. The implementation bundle interventions on July successfully controlled further horizontal spread this organism.
We report novel polymyxin analogues with improved antibacterial in vitro potency against resistant recent clinical isolates of Acinetobacter baumannii and Pseudomonas aeruginosa . In addition, a human renal cell assay (hRPTEC) was used to inform structure-toxicity relationships further differentiate analogues. Replacement the Dab-3 residue Dap-3 combination relatively polar 6-oxo-1-phenyl-1,6-dihydropyridine-3-carbonyl side chain as fatty acyl replacement yielded analogue 5x, which...
Multidrug-resistant Gram-negative pathogens are an emerging threat to human health, and addressing this challenge will require development of new antibacterial agents. This can be achieved through improved molecular understanding drug–target interactions combined with enhanced delivery these agents the site action. Herein we describe first application siderophore receptor-mediated drug uptake lactivicin analogues as a strategy that enables novel against clinically relevant bacteria. We...
In over a decade (2002 to 2012) of Staphylococcus aureus surveillance testing on 62,195 isolates, dalbavancin was demonstrated be active against isolates that were either susceptible or nonsusceptible daptomycin, linezolid, tigecycline. Nearly all (99.8%) multidrug-resistant methicillin-resistant S. inhibited by at ≤0.12 μg/ml (MIC50/90, 0.06/0.06 μg/ml), the current U.S. Food and Drug Administration (U.S. FDA) breakpoint. Overall, only 0.35% monitored had MIC 0.25 0.5 (i.e., nonsusceptible).
ObjectivesThe prevalence of linezolid-resistant coagulase-negative Staphylococcus (CoNS) in the MD Anderson Cancer Center rose from 0.6% 2007 to 5.5% 2009. The aim our study was analyse relationship between linezolid use and an outbreak CoNS.
Delafloxacin is a novel fluoroquinolone with activity against Gram-positive, Gram-negative, and atypical pathogens, including fluoroquinolone-nonsusceptible methicillin-resistant Staphylococcus aureus (MRSA). The microbiological results of phase 3 clinical trial in adults community-acquired pneumonia (CAP) comparing delafloxacin (300 mg intravenously [i.v.] the option to switch 450 orally every 12 h) moxifloxacin (400 i.v.
Antimicrobial susceptibility testing (AST) is performed to assess the in vitro activity of antimicrobial agents against various bacteria. The AST results, which are expressed as minimum inhibitory concentrations (MICs) used research for development and monitoring resistance clinical setting therapy guidance. Dalbavancin a semi-synthetic lipoglycopeptide agent that was approved May 2014 by Food Drug Administration (FDA) treatment acute bacterial skin structure infections caused Gram-positive...
The noncollagenous proteins, expecially phosphoprotein, have been shown to modulate biomineralization. objective of this study was investigate the remineralization potential human tooth root organic matrices which did or not contain soluble non-collagenous proteins including phosphoprotien. Human roots were completely demineralized using conditions that either removed remove phosphoprotein and then subjected conditions. Removal resulted in while no occurred still contained phosphoprotein....
To report atypical pathogens from clinical trial data comparing delafloxacin to moxifloxacin in the treatment of adults with community-acquired bacterial pneumonia (CABP).Multiple diagnostic methods were employed diagnose infections including culture, serology, and urinary antigen.The microbiological intent-to-treat (MITT) population included 520 patients; 30% had an pathogen identified (156/520). Overall, 13.1% (68/520) a monomicrobial infection 2.3% (12/520) polymicrobial all-atypical...