A5042349932- Genomics, phytochemicals, and oxidative stress
- RNA modifications and cancer
- IL-33, ST2, and ILC Pathways
- Air Quality and Health Impacts
- Case Reports on Hematomas
- Lung Cancer Research Studies
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Lung Cancer Treatments and Mutations
- Radiation Dose and Imaging
- interferon and immune responses
- Facial Trauma and Fracture Management
- Traumatic Ocular and Foreign Body Injuries
- Advanced X-ray and CT Imaging
- Hydrogen's biological and therapeutic effects
- Phagocytosis and Immune Regulation
- Birth, Development, and Health
- Circadian rhythm and melatonin
- Nitrogen and Sulfur Effects on Brassica
- Neuroblastoma Research and Treatments
- Smoking Behavior and Cessation
- Cancer, Lipids, and Metabolism
- Noise Effects and Management
University of Maryland, Baltimore
2018-2023
Johns Hopkins University
2014-2023
University of Maryland Medical Center
2018
University of Toledo
2011-2018
Loss of function mutations in Kelch-like ECH Associated Protein 1 (KEAP1), or gain-of-function nuclear factor erythroid 2-related 2 (NRF2), are common non-small cell lung cancer (NSCLC) and associated with therapeutic resistance. To discover novel NRF2 inhibitors for targeted therapy, we conducted a quantitative high-throughput screen using diverse set ∼400 000 small molecules (Molecular Libraries Small Molecule Repository Library, MLSMR) at the National Center Advancing Translational...
Electronic cigarettes (E-cigs) have experienced sharp increases in popularity over the past five years due to many factors, including aggressive marketing, increased restrictions on conventional cigarettes, and a perception that E-cigs are healthy alternatives cigarettes. Despite this perception, studies health effects humans extremely limited vivo animal models not been generated. Presently, we determined E-cig vapor contains 7x1011 free radicals per puff. To determine whether exposure...
Clinical guidelines recommend low-molecular-weight heparin for thromboprophylaxis in patients with fractures, but trials of its effectiveness as compared aspirin are lacking.
Purpose:. Stabilization of the transcription factor NRF2 through genomic alterations in KEAP1 and NFE2L2 occurs a quarter patients with lung adenocarcinoma third squamous cell carcinoma. In adenocarcinoma, loss often co-occurs STK11 KRAS-activating alterations. Despite its prevalence, impact activation on tumor progression patient outcomes is not fully defined.Experimental Design:. We model activation, loss, KRAS vivo using novel genetically engineered mouse models. Furthermore, we derive...
Background COPD patients have high pulmonary and systemic oxidative stress that correlates with severity of disease. Sulforaphane has been shown to induce expression antioxidant genes via activation a transcription factor, nuclear factor erythroid-2 related 2 (Nrf2). Methods This parallel, placebo-controlled, phase 2, randomized trial was conducted at three US academic medical centers. Patients who met GOLD criteria for were able tolerate bronchoscopies randomly assigned (1:1:1) receive...
Asthma development and pathogenesis are influenced by the interactions of airway epithelial cells innate adaptive immune in response to allergens. Oxidative stress is an important mediator asthmatic phenotypes these cell types. Nuclear erythroid 2-related factor 2 (Nrf2) a redox-sensitive transcription that key regulator oxidative environmental stress. We previously demonstrated Nrf2-deficient mice have heightened susceptibility asthma, including elevated stress, inflammation, mucus,...
ABSTRACT Oncogenic Kras mutations are one of the most common alterations in non‐small cell lung cancer and associated with poor response to treatment reduced survival. Driver oncogenes, such as now appreciated for their ability promote tumor growth via up‐regulation anabolic pathways. Therefore, we wanted identify metabolic vulnerabilities Kras‐mutant cancer. Using LSL‐G12D model, show that mutant drives a lipogenic gene‐expression program. Stable‐isotope analysis reveals promotes de novo...
To determine the specific facial computed tomographic (CT) findings that can be used to predict traumatic optic neuropathy (TON) in patients with blunt craniofacial trauma and propose a scoring system identify at highest risk of TON.This study was compliant HIPAA, permission obtained from institutional review board. Facial CT examination 637 consecutive history were evaluated retrospectively. The following variables evaluated: midfacial fractures, extraconal hematoma, intraconal hematoma...
<h3>BACKGROUND AND PURPOSE:</h3> Extravasation of iodinated contrast into subdural space following contrast-enhanced radiographic studies results in hyperdense effusions, which can be mistaken as acute hematomas on follow-up noncontrast head CTs. Our aim was to identify the factors associated with contrast-enhancing effusion, characterize diffusion and washout kinetics iodine enhancing assess utility dual-energy CT differentiating effusion from hematoma. <h3>MATERIALS METHODS:</h3> We...
Introduction Patients who sustain orthopaedic trauma are at an increased risk of venous thromboembolism (VTE), including fatal pulmonary embolism (PE). Current guidelines recommend low-molecular-weight heparin (LMWH) for VTE prophylaxis in patients. However, emerging literature total joint arthroplasty patients suggests the potential clinical benefits with aspirin. The primary aim this trial is to compare aspirin LMWH as a thromboprophylaxis fracture Methods and analysis PREVENT CLOT...
Rheumatoid arthritis (RA) is characterized by hyperplastic pannus formation mediated activated synovial fibroblasts that cause joint destruction. We have shown earlier RA (RASFs) exhibit resistance to apoptosis, primarily as a result of enhanced expression myeloid cell leukemia-1 (Mcl-1). In this study, we discovered ursolic acid (UA), plant-derived pentacyclic triterpenoid, selectively induces B-cell lymphoma 2 homology 3-only protein Noxa in human RASFs. observed UA-induced was followed...
Abstract Preterm birth (PTB) is the leading cause of neonatal mortality, and surviving infants are at increased risk for lifelong disabilities. Intrauterine inflammation an etiological factor that drives PTB, oxidative stress associated with PTB. Nuclear erythroid 2-related 2 ( Nrf2 ) a redox-sensitive transcription key regulator response to inflammatory stress. Here, we used established mouse model intrauterine inflammation-induced PTB determine whether modifier susceptibility...
Patients with chronic obstructive pulmonary disease (COPD) have high oxidative stress associated the severity of disease. Nuclear factor erythroid-2 related 2 (Nrf2)-directed response plays a critical role in protection lung cells to by upregulating antioxidant genes tobacco smoke. There is gap our knowledge about Nrf-2 regulated active smokers and former-smokers COPD different cell types from lungs surrogate peripheral tissues. We compared expression Nrf2 six its target alveolar...
<h3>BACKGROUND AND PURPOSE:</h3> In patients with hemorrhagic contusions, hematoma volumes are overestimated on follow-up standard 120-kV images obtained after contrast-enhanced whole-body CT. We aimed to retrospectively determine progression of contusion rates and 190-keV derived from dual-energy CT the magnitude volume overestimation. <h3>MATERIALS METHODS:</h3> analyzed admission studies in 40 contusions. After annotating we measured using semiautomated 3D segmentation. Bland-Altman...
<h3>BACKGROUND AND PURPOSE:</h3> The present prognostic models for open globe injuries have a limited ability to predict visual outcome before comprehensive ophthalmologic examination or operation because they depend on the data derived from and intraoperative findings. purpose of our study was determine specific CT preoperative clinical that can prognosis injury. <h3>MATERIALS METHODS:</h3> We analyzed relationship 29 variables 97 with acuity at 1 month. A prediction model 49 by regression...
<p>Fig. S1, related to Figs 1 & 2. Tumor histology across genotypes at 8-16 weeks after Adeno-Cre infection.</p>
<p>Fig. S5, related to Fig. 5.</p>
<p>Supplementary Legends, Materials and Methods</p>
<p>Fig. S3, related to Fig. 3.</p>