A5090205025- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Attention Deficit Hyperactivity Disorder
- Neuroscience and Music Perception
- Multisensory perception and integration
- Neuroscience and Neuropharmacology Research
- Visual perception and processing mechanisms
- Heart Rate Variability and Autonomic Control
- Cognitive Abilities and Testing
- Health disparities and outcomes
- Music and Audio Processing
- Face Recognition and Perception
- Grit, Self-Efficacy, and Motivation
- Radio Frequency Integrated Circuit Design
- Eating Disorders and Behaviors
- Educational Outcomes and Influences
- Education, Achievement, and Giftedness
- Consumer Attitudes and Food Labeling
- Evolution and Science Education
- Neurobiology of Language and Bilingualism
- Advanced Neuroimaging Techniques and Applications
- Anesthesia and Sedative Agents
Pontificia Universidad Católica de Chile
2014-2025
Universidad Católica del Norte
2022
Centre National de la Recherche Scientifique
2010-2012
Centre de Recherche en Neurosciences de Lyon
2010-2012
Inserm
2008-2012
Université Claude Bernard Lyon 1
2008-2012
Centre Hospitalier Le Vinatier
2011
University of Chile
2005-2008
Task performance is associated with increased brain metabolism but also prominent deactivation in specific structures known as the default-mode network (DMN). The role of DMN remains enigmatic part because its electrophysiological correlates, temporal dynamics, and link to behavior are poorly understood. Using extensive depth electrode recordings humans, we provide first evidence for a direct correlation between dynamics power decreases individual subject behavior. We found that all areas...
While functional imaging studies allow for a precise spatial characterization of resting state networks, their neural correlates and thereby fine-scale temporal dynamics remain elusive. A full understanding the mechanisms at play requires input from electrophysiological studies. Here, we discuss human non-human primate data that explore default-mode network. Beyond promising findings obtained with non-invasive approaches, emerging evidence suggests invasive recordings in humans will be...
As you might experience it while reading this sentence, silent often involves an imagery speech component: we can hear our own “inner voice” pronouncing words mentally. Recent functional magnetic resonance imaging studies have associated that component with increased metabolic activity in the auditory cortex, including voice-selective areas. It remains to be determined, however, whether activation arises automatically from early bottom-up visual inputs or depends on late top-down control...
Attention-deficit/hyperactivity disorder (ADHD) diagnosis is based on reported symptoms, which carries the potential risk of over- or under-diagnosis. A biological marker that helps to objectively define disorder, providing information about its pathophysiology, needed. promising cognitive states in humans pupil size, reflects activity an 'arousal' network, related norepinephrine system. We monitored size from ADHD and control subjects, during a visuo-spatial working memory task. sub group...
Abstract Music perception is plausibly constrained by universal perceptual mechanisms adapted to natural sounds. Such constraints could arise from our dependence on harmonic frequency spectra for segregating concurrent sounds, but evidence has been circumstantial. We measured the extent which musical notes are misperceived as a single sound, testing Westerners well native Amazonians with limited exposure Western music. Both groups were more likely mistake note combinations related simple...
Abstract Characterization of brain states is essential for understanding its functioning in the absence external stimuli. Brain differ on their balance between excitation and inhibition, diversity activity patterns. These can be respectively indexed by 1/f slope Lempel–Ziv complexity (LZc). However, whether how these two state properties relate remain elusive. Here we analyzed relation LZc with in-silico approaches both rat EEG monkey ECoG data. We contrasted resting propofol anesthesia,...
The specificity of neural responses to visual objects is a major topic in neuroscience. In humans, functional magnetic resonance imaging (fMRI) studies have identified several regions the occipital and temporal lobe that appear specific faces, letter-strings, scenes, or tools. Direct electrophysiological recordings cortical areas epileptic patients largely confirmed this modular organization, using either single-neuron peri-stimulus time-histogram intracerebral event-related potentials...
Reading sentences involves a distributed network of brain regions acting in concert surrounding the left sylvian fissure. The mechanisms neural communication underlying extraction and integration verbal information across subcomponents this reading are still largely unknown. We recorded intracranial EEG activity 12 epileptic human patients performing natural sentence analyzed long-range corticocortical interactions between local activations. During simple task contrasting semantic,...
An object that differs markedly from its surrounding—for example, a red cherry among green leaves—seems to pop out effortlessly in our visual experience. The rapid detection of salient targets, independently the number other items scene, is thought be mediated by efficient search brain mechanisms. It not clear, however, whether actually an “effortless” bottom-up process or it also involves regions prefrontal cortex generally associated with top-down sustained attention. We addressed this...
Cognitive planning, the ability to develop a sequenced plan achieve goal, plays crucial role in human goal-directed behavior. However, specific of frontal structures planning is unclear. We used novel and ecological task, that allowed us separate period from execution period. The spatio-temporal dynamics EEG recordings showed induced progressive sustained increase frontal-midline theta activity (FMθ) over time. Source analyses indicated this was generated within prefrontal cortex. Theta...
Adaptive behavior requires the comparison of outcome predictions with actual outcomes (e.g., performance feedback). This process monitoring is computed by a distributed brain network comprising medial prefrontal cortex (mPFC) and anterior insular (AIC). Despite being consistently co-activated during different tasks, precise neuronal computations each region their interactions remain elusive. In order to assess neural mechanism which AIC processes feedback, we recorded electrophysiological...
Fast oscillatory bursts (OBs; 500-600 Hz) are the most prominent response to visual stimulation in optic tectum of birds. To investigate neural mechanisms generating tectal OBs, we compared local recordings OBs with simultaneous intracellular and extracellular single-unit anesthetized pigeons. We found a specific population units that responded burst discharges mirrored pattern OBs. Intracellular filling biocytin some these bursting demonstrated they corresponded paintbrush axon terminals...
Previous research has shown that the autonomic nervous system provides essential constraints over ongoing cognitive function. However, there is currently a relative lack of direct empirical evidence for how this interaction manifests in brain at macroscale level. Here, we examine role ascending arousal and attentional load on large-scale network dynamics by combining pupillometry, functional MRI, graph theoretical analysis to analyze data from visual motion-tracking task with parametric...
Attention Deficit/Hyperactive Disorder (ADHD) is diagnosed based on observed behavioral outcomes alone. Given that some brain attentional networks involve circuits control the eye pupil, we monitored pupil size in ADHD- children and also during a visuospatial working memory task. We present here full dataset, consisting of time series for each trial subject. There are data from, 22 control, 28 ADHD-diagnosed children. from subset 17 ADHD performed task twice, on- off-medication. In addition,...
Abstract Evaluating the outcome of our own actions is a fundamental process by which we adapt behavior in interaction with external world. fMRI and electrophysiological studies monkeys have found feedback‐specific responses several brain regions, unveiling facets large‐scale network predominantly distributed frontal lobes. However, consensus has yet to be reached regarding exact contribution each region. The present study benefited from intracerebral EEG recordings epileptic patients record...
The capacity to inhibit prepotent and automatic responses is crucial for proper cognitive social development, inhibitory impairments have been considered be key some neuropsychiatric conditions. One of the most used paradigms analyze processes Go-Nogo task (GNG). This has widely in psychophysical EEG studies, more recently using fMRI. However, a technical limitation that time resolution fMRI poorer than technique. In order compensate these temporal constraints, it become common practice...
Characterization of brain states is essential for understanding its functioning in the absence external stimuli. Brain differ on their balance between excitation and inhibition, diversity activity patterns. These can be respectively indexed by 1/f slope Lempel-Ziv Complexity (LZc). However, whether how these two state properties relate remain elusive. Here we analyzed relation LZc with in-silico approaches both rat EEG monkey ECoG data. We contrasted resting propofol anesthesia, which...