A5036297058- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Hemodynamic Monitoring and Therapy
- Nausea and vomiting management
- Antibiotics Pharmacokinetics and Efficacy
- Epilepsy research and treatment
- Veterinary Pharmacology and Anesthesia
- EEG and Brain-Computer Interfaces
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Pharmacogenetics and Drug Metabolism
- Airway Management and Intubation Techniques
- Analytical Chemistry and Sensors
- Frailty in Older Adults
- Pharmaceutical studies and practices
- Organ Transplantation Techniques and Outcomes
- Analytical Methods in Pharmaceuticals
- Pain Management and Opioid Use
- Pharmacology and Obesity Treatment
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Pediatric Pain Management Techniques
Pontificia Universidad Católica de Chile
2016-2025
Universidade Federal de Juiz de Fora
2020
Committee on Publication Ethics
2020
University of Utah
2020
Massachusetts General Hospital
2020
GTx (United States)
2018
Hospital Clínico de la Universidad Católica
2004-2017
University of Groningen
2015
University Medical Center Groningen
2015
Ghent University
2015
Dexmedetomidine, a highly selective alpha2-adrenoceptor agonist used for short-term sedation of mechanically ventilated patients, has minimal effect on ventilation.This study compared the respiratory dexmedetomidine to that remifentanil. The authors measured and responses six healthy male volunteers during (1) stepwise target-controlled infusion remifentanil, (2) dexmedetomidine, (3) pseudonatural sleep session.Compared with baseline, remifentanil infusions resulted in depression as...
Pharmacokinetic (PK) models are used to predict drug concentrations for infusion regimens intraoperative displays and calculate rates in target-controlled systems. For propofol, the PK available literature were mostly developed from particular patient groups or anesthetic techniques, there is uncertainty of accuracy under differing clinical conditions. Our goal was determine a model with robust predictive performance wide range conditions.We aggregated analyzed 21 previously published...
Frail elderly patients have a higher risk of postoperative morbidity and mortality. Prehabilitation is potential intervention for optimizing outcomes in frail patients. We studied the impact prehabilitation program on length stay (LOS) undergoing elective surgery. An RCT study was conducted. scheduled surgery were randomized to receive either pre-surgical conditioning protocol (PCP) or standard preoperative care. PCP included nursing, anesthetic, geriatric assessment, nutritional...
In Brief BACKGROUND: Obesity is associated with important physiologic changes that can potentially affect the pharmacokinetic (PK) and pharmacodynamic (PD) profile of anesthetic drugs. We designed this study to assess predictive performance 5 currently available propofol PK models in morbidly obese patients characterize Bispectral Index (BIS) response population. METHODS: Twenty (body mass index >35 kg/m2), aged 20 60 years, scheduled for laparoscopic bariatric surgery, were studied....
Dexmedetomidine is a highly selective alpha2-adrenoceptor agonist used for short-term sedation of mechanically ventilated patients. The analgesic profile dexmedetomidine has not been fully characterized in humans.This study was designed to compare the responses six healthy male volunteers during stepwise target-controlled infusions remifentanil and dexmedetomidine. A computer-controlled thermode deliver painful heat stimuli volar side forearms subjects. Six sequential 5-s (ranging from 41...
Summary Pulse oximeters may delay displaying the correct oxygen saturation during onset of hypoxia. We investigated desaturation response times pulse oximeter sensors (forehead, ear and finger) vasoconstriction due to mild hypothermia vasodilation caused by glyceryl trinitrate. Ten healthy male volunteers were given three hypoxic challenges 3 min duration under differing experimental conditions. Mild increased mean time finger from 130 215 s. Glyceryl trinitrate partly offset this effect...
Abstract Aims Manual propofol infusion regimens for neonates and infants have been determined from clinical observations in children under the age of 3 years undergoing anesthesia. We assessed performance these using reported age‐specific pharmacokinetic parameters propofol. Where was poor, we propose alternative dosing regimens. Methods Simulations a general purpose model were used to predict blood plasma concentrations during manual recommended 0‐3 years. Simulated steady state 6‐8 µg.mL...
A universal pharmacokinetic model was developed from pooled paediatric and adult data (40.6 postmenstrual weeks, 70.8 years, 3.1-152 kg). three-compartment with first-order elimination superior to a two-compartment describe these dexmedetomidine data. Population parameter estimates (population variability%) were clearance (CL) 0.9 L/min/70 kg (36); intercompartmental clearances (Q2) 1.68 (63); Q3 0.62 (90); volume of distribution in the central compartment (V1) 25.2 L/70 (103.9); rapidly...
Targeting the effect site concentration may offer advantages over traditional forms of administrating intravenous anesthetics. Because lack plasma equilibration rate constant (ke0) for propofol in children precludes use this technique population, authors estimated value ke0 using time to peak (tpeak) method and two pharmacokinetic models children.: The tpeak after a submaximal bolus dose was measured by means Alaris A-Line auditory evoked potential monitor (Danmeter A/S, Odense, Denmark) 25...
Improving anesthesia administration for elderly population is of particular importance because they undergo considerably more surgical procedures and are at the most risk suffering from anesthesia-related complications. Intraoperative brain monitors electroencephalogram (EEG) have proved useful in general population, however, subjects this contentious. Probably these do not account natural differences EEG signals between young older patients. In study we attempted to systematically...