A5012890979- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Vascular Malformations and Hemangiomas
- Colorectal Cancer Screening and Detection
- Intraperitoneal and Appendiceal Malignancies
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Pancreatitis Pathology and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Adipose Tissue and Metabolism
- Galectins and Cancer Biology
- Andrographolide Research and Applications
- Neuroblastoma Research and Treatments
Pontificia Universidad Católica de Chile
2016-2025
University Medical Center Groningen
2020
University of Groningen
2020
Paññāsāstra University of Cambodia
2018
Fundación Arturo López Pérez
2016
Memorial Sloan Kettering Cancer Center
2012
Hospital San Borja Arriarán
2010
Hospital Del Mar
1989
Summary Streptococcus pneumoniae is a major aetiological agent of pneumonia worldwide, as well otitis media, sinusitis, meningitis and sepsis. Recent reports have suggested that inflammation lungs due to S. infection promotes bacterial dissemination severe disease. However, the contribution anti‐inflammatory molecules pathogenesis remains unknown. To elucidate whether production cytokine interleukin‐10 (IL‐10) beneficial or detrimental for host during pneumococcal pneumonia, we performed...
Therapy for nonalcoholic steatohepatitis (NASH) is limited. Andrographolide (ANDRO), a botanical compound, has potent anti-inflammatory activity due to its ability inhibit NF-κB. ANDRO been also shown the NLRP3 inflammasome, relevant pathway in NASH. Our aim was evaluate effects of NASH and influence on inflammasome activation this setting. Thus, mice were fed choline-deficient-amino-acid-defined (CDAA) diet with/without concomitant administration (1 mg/kg, 3-times/week). Also, we assessed...
Although most tumors of the bile ducts are predominantly invasive, some have an exophytic pattern within ducts; these intraductal papillary neoplasms usually well-formed papillae at microscopic level. In this study, however, we describe a novel type neoplasm with tubular growth and other distinctive features. Ten cases biliary architecture were identified in files Pathology Department Memorial Sloan-Kettering Cancer Center from 1983 to 2006. For each studied clinical presentation, histologic...
We present the case of a 29-year-old female with chronic jaundice and history dyshidrosis, previously treated cyclosporine. She also had hypertriglyceridemia managed fibrates was referred for evaluation gallstone disease. Imaging confirmed gallstones without bile duct abnormalities. Laboratory tests revealed conjugated hyperbilirubinemia (total bilirubin: 3.0 mg/dL, direct 2.95 mg/dL). During laparoscopic cholecystectomy, striking blue liver appearance observed. A biopsy Dubin-Johnson...
Chronic intestinal inflammations are triggered by genetic and environmental components. However, it remains unclear how specific changes in the microbiota, host immunity or pathogen exposure could promote onset exacerbation of these diseases. Here, we evaluated whether Salmonella enterica serovar Typhimurium (S. Typhimurium) infection increases susceptibility to develop inflammation mice. Two mouse models were used evaluate impact S. infection: chemical induction colitis Dextran Sulfate...
Gastric cancer (GC) is a heterogeneous disease. This heterogeneity applies not only to morphological and phenotypic features but also geographical variations in incidence mortality rates. As Chile has one of the highest rates within South America, we sought define molecular profile Chilean GCs (ClinicalTrials.gov identifier: NCT03158571/(FORCE1)). Solid tumor samples clinical data were obtained from 224 patients, with subsets analyzed by tissue microarray (TMA; n = 90) next generation...
Peptic ulcer disease (PUD) is highly prevalent among adults but less common in children. Helicobacter pylori infection, the main cause of PUD, is, however, acquired extremely early life. The aim study was to analyze clinical characteristics children with PUD a country high prevalence and evaluate which host factors could determine this outcome.Children referred for upper gastrointestinal (GI) endoscopy suspicion peptic diseases were included prospectively during an 8-year period. Antral...
Background: Papillary thyroid cancer (PTC), the most prevalent type of differentiated carcinoma, displays a strikingly high frequency lymph node metastasis (LNM). Recent data suggest that chemokines can play an important role in promoting tumor progression and metastatic migration cells. Here we have evaluated whether PTC tissues express different pattern chemokine receptors if expression these correlates with LNM. Methods: We assessed by immunohistochemistry flow cytometry CCR3, CCR7, CXCR4...
Histologic assessment of high-risk gastritis for the development gastric cancer is not well defined. The identification tissue markers together with integration histologic features will be required this assessment.Matched tumor/nontumor adjacent mucosa (NTAM) 91 early and 148 chronic cases were evaluated characteristics (atrophy, intestinal metaplasia, inflammation, polymorphonuclear infiltration, Helicobacter pylori) by Sydney System. Atrophy risk was also Operative Link on Gastritis...
Gastric cancer (GC) is a complex and heterogeneous disease. In recent decades, The Cancer Genome Atlas (TCGA) the Asian Research Group (ACRG) defined GC molecular subtypes. Unfortunately, these systems require high-cost techniques consequently their impact in clinic has remained limited. Additionally, most of studies are based on European, Asian, or North American cohorts. Herein, we report classification Chilean patients into five subtypes, immunohistochemical (IHC) situ hybridization (ISH)...
Objectives We evaluated allergy/hypersensitivity clinical markers and their correlation with Helicobactor pylori infection in children adults to analyze how early acquisition of H. could modulate allergic disorder expression. Patients methods presence was assessed by the rapid urease test histology antrum biopsies 165 patients. Skin tests, serum IgE, two allergy questionnaires were performed. Allergy severity operationally defined using a combined score. Findings correlated status...
Germline pathogenic variants in the CDH1 gene are a well-established cause of hereditary diffuse gastric cancer (HDGC) syndrome. The aim this study was to characterize mutations associated with HDGC from Chile, country one highest incidence and mortality rates world for (GC). Here, we prospectively include probands family history/early onset diffuse-type GC. whole coding sequence sequenced genomic DNA all patients, multidisciplinary team managed each member variant. Thirty-six cases were...
The diagnostic value of antibody detection by indirect hemagglutination (IHA), immunofluorescence (IFA), and counterimmunoelectrophoresis (CIE) Candida albicans mannan antigen latex agglutination was studied in 36 cases systemic candidiasis heroin addicts. IHA IFA techniques were highly sensitive (97% 91%, respectively), but their specificity low (60% 50%). When a titer greater than or equal to 1:2,560 used as criterion for positivity, the test rose 87%, with sensitivity at 75%. CIE had high...
Gastric cancer (GC) is the world's second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC leading death in Chile, affecting 17.6 per 100,000 people causing >3000 deaths/y. Clinical outcomes "one size fits all" therapies thus a better stratification patients may aid treatment response.The Cancer Task Force Chilean collaborative, noninterventional study that seeks...
Neuroendocrine tumors (NETs) are relatively rare and highly heterogeneous neoplasms. Despite this, recent studies from North America Central Europe have suggested an increase in incidence. In Latin America, NET data scarce scattered with only a few reporting registries. Our goal was to establish registry Chile. Here, we report the establishment our first 166 patients. We observed slight preponderance of males, median age at diagnosis 53 years overall survival 110 months. As anticipated, most...