A5059323366- Trypanosoma species research and implications
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Social Sciences and Policies
- Intensive Care Unit Cognitive Disorders
- Pain Management and Opioid Use
- Anesthesia and Neurotoxicity Research
- Frailty in Older Adults
- Genetic factors in colorectal cancer
- Shoulder Injury and Treatment
- Ethics and bioethics in healthcare
- Nutrition, Genetics, and Disease
- Health and Medical Education
- Toxin Mechanisms and Immunotoxins
- Religious and Theological Studies
- Research on Leishmaniasis Studies
- EEG and Brain-Computer Interfaces
- Public Health and Social Inequalities
- Pain Mechanisms and Treatments
- Treatment of Major Depression
- Pediatric Pain Management Techniques
- High-Temperature Coating Behaviors
- Dental Anxiety and Anesthesia Techniques
- Nausea and vomiting management
Pontificia Universidad Católica de Chile
2012-2024
Vividion Therapeutics (United States)
2023-2024
University of Florida
2022
Diego Portales University
2022
Central University of Venezuela
2018
University of Carabobo
2007-2013
Janssen (Belgium)
2013
Hospital Regional de Concepción
2011
Fundação Oswaldo Cruz
1985
The synthesis and preclinical characterization of two novel, brain penetrating P2X7 compounds will be described. Both are shown to high potency antagonists in human, rat, mouse cell lines both were have concentrations robust receptor occupancy rat. Compound 7 is particular interest as a probe compound for the assessment blockade animal models neuro-inflammation.
Summary Background Propofol and remifentanil are commonly combined during total intravenous anesthesia. The impact of in this relationship is poorly quantified children. Derivation an integrated pharmacokinetic pharmacodynamic propofol model, containing interaction information, enables effect‐site target‐controlled infusion children with a better prediction its hypnotic effect when both drugs combined. Aims We designed study to derive pharmacokinetic‐pharmacodynamic model describe the...
Introduction Oral transmission of T. cruzi is probably the most frequent mechanism in wild animals. This observation led to hypothesis that consuming raw or undercooked meat from animals infected with may be responsible for transmitting infection. Therefore, general objective this study was investigate host-pathogen interactions between parasite and gastric mucosa role consumption oral cruzi. Methods Cell infectivity assays were performed on AGS cells presence absence mucin, roles pepsin...
Abstract WRN helicase is a promising target for treating cancers with microsatellite instability (MSI) due to its essential role in resolving deleterious non-canonical DNA structures that accumulate cells faulty mismatch repair mechanisms. Currently, there are no approved drugs directly targeting human or RNA helicases, part the challenging nature of developing potent and selective compounds this class proteins. Here we describe chemical proteomic-enabled discovery clinical-stage, covalent...
Summary Mechanisms underlying loss of consciousness following propofol administration remain incompletely understood. The objective this study was to compare frontal lobe electroencephalography activity and brainstem reflexes during intravenous induction general anaesthesia, in patients receiving a typical bolus dose (fast infusion) compared with slower infusion rate. We sought determine whether suppression (‘bottom‐up’) predominates over cortical function (‘top‐down’). Sixteen ASA physical...
Abstract The WRN helicase serves as a key target in the treatment of cancers characterized by microsatellite instability (MSI) because it plays crucial role resolving harmful non-canonical DNA structures that arise cells with defective mismatch repair systems. Despite critical functions human and RNA helicases, no drugs targeting these enzymes have been approved, largely due to difficulties identifying potent selective inhibitors. In this study, we present chemoproteomics-based...
The Nociception Level Index has shown benefits in estimating the nociception/antinociception balance adults, but there is limited evidence pediatric population. Evaluating index performance children might provide valuable insights to guide opioid administration.
<title>Abstract</title> Purpose An effect-site target-controlled infusion (TCI) would allow a more precise titration of intravenous analgesics effect. The analgesia nociception index (ANI) continuously monitors the analgesia/nociception balance during general anesthesia. This study aims to derive PKPD model ketamine an TCI administration using ANI information and previously described pharmacokinetic parameters. Methods Twenty adult patients under anesthesia were prospectively studied....
BACKGROUND: Cardiopulmonary bypass (CPB) induces profound physiological changes that may alter the pharmacokinetics of methadone. We aimed to describe an intravenous bolus methadone racemate in adult patients undergoing heart surgery with CPB. METHODS: prospectively studied 29 aged 45 75 years scheduled for cardiac CPB who received 0.2 mg/kg after anesthesia induction. Arterial blood samples (n = 10) were taken, before, during, and Pharmacokinetic analysis was undertaken using nonlinear...
Introduction:The waste management of a hospital center affects people both those who receive health care and the environment that receives them.The impact on task peri-operative has not yet been properly studied.It is known 105 tons garbage monthly from understudy go to landfills municipality.However, there are different elements, such as low-density plastics (LDP), which can be recycled.Objective: implement clean recycling program in central Operating Room UC-Christus Clinical...
Pretende ser un referente nacional e internacional en el ámbito de la enfermería y salud, reconocida por su aporte divulgación del conocimiento constituir espacio diálogo entre los diferentes profesionales salud como otras disciplinas torno a las personas.
Pretende ser un referente nacional e internacional en el ámbito de la enfermería y salud, reconocida por su aporte divulgación del conocimiento constituir espacio diálogo entre los diferentes profesionales salud como otras disciplinas torno a las personas.
Las propiedades de los recubrimientos a base circonia estabilizada con ytria (YSZ) confieren estos un excelente desempeño en una amplia gama aplicaciones que van desde el uso odontológico hasta barreras térmicas, incluyendo también su empleo como electrolitos sólidos celdas combustible. En presente trabajo, se depositaron nanoestructurados delgados 75 μm 8YSZ sobre sustrato la superaleación Haynes 230, mediante proceso termorrociado por plasma suspensión (SPS), fin servir enlace (subcapa)...