A5053873808- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- EEG and Brain-Computer Interfaces
- Anesthesia and Neurotoxicity Research
- Agricultural and Food Production Studies
- Trace Elements in Health
- Child Nutrition and Water Access
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Anesthesia and Pain Management
- Neural and Behavioral Psychology Studies
- Pain Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Stress and Burnout Research
- Visual Attention and Saliency Detection
- Heart Rate Variability and Autonomic Control
- Public Health and Environmental Issues
- Stress Responses and Cortisol
- Infant Nutrition and Health
- Respiratory Support and Mechanisms
- Magnesium in Health and Disease
- Face Recognition and Perception
- Metabolism and Genetic Disorders
University of Chile
1991-2023
Hospital Clínico de la Universidad de Chile
2013-2023
Instituto de Neurociencia Biomédica
2013-2020
NationsUniversity
1983
United Nations
1983
Currently, the diagnosis of schizophrenia is made solely based on interviews and behavioral observations by a trained psychiatrist. Technologies such as electroencephalography (EEG) are used for differential not to support psychiatrist's positive diagnosis. Here, we show potential EEG recordings biomarkers syndrome. We recorded while patients freely viewed natural scenes, analyzed average activity locked image onset. found significant differences between healthy controls in occipital areas...
Postoperative delirium (PD) and subsyndromal (PSSD) are frequent complications in older patients associated with poor long-term outcome. It has been suggested that certain electroencephalogram features may be capable of identifying at risk during surgery. Thus, the goal this study was to characterize intraoperative electroencephalographic markers identify prone develop PD or PSSD.We conducted an exploratory observational scheduled for elective major abdominal Intraoperative 16 channels...
Variations in human behavior correspond to the adaptation of nervous system different internal and environmental demands. Attention, a cognitive process for weighing demands, changes over time. Pupillary activity, which is affected by fluctuating levels processing, appears identify neural dynamics that relate states attention. In mice, example, pupil directly correlate with brain state fluctuations. Although, humans, alpha-band activity associated inhibitory processes cortical networks...
Patients who develop postoperative delirium (POD) have several clinical complications, such as increased morbidity, hospital stays, higher costs, cognitive and functional impairment, mortality. POD is a condition preventable by standard non-pharmacological measures An intensive Occupational Therapy (OT) intervention has been shown to be highly effective in preventing critically ill medical patients, but it unknown the effect surgical patients. Thus, we designed prospective study with aim...
In schizophrenia, patients display dysfunctions during the execution of simple visual tasks such as anti-saccade or smooth pursuit. more ecological scenarios, free viewing natural images, appear to make fewer and longer fixations shorter scanpaths. It is not clear whether these measurements reflect alterations in their proficiency perform basic eye movements, saccades fixations, are related high-level mechanisms, exploration attention. We utilized images different complexities a model an...
Patients with low cognitive performance are thought to have a higher risk of postoperative neurocognitive disorders. Here we analyzed the relationship between preoperative cognition and anesthesia-induced brain dynamics. We hypothesized that patients would be more sensitive anesthetics show differences in electroencephalogram (EEG) activity consistent anesthesia overdose.
Purpose: This study aimed to compare the effects of ketamine and associated with magnesium on opioid consumption pain scores in patients undergoing abdominoplasty and/or liposuction compared standard treatment. Patients Methods: A total 63 were included randomized as follows: 21 Control group, 20 Ketamine group (Ket), 22 Ketamine-magnesium (KetMag). The KetMag received an IV bolus 0.3 mg/kg 50 magnesium, followed by continuous infusion (0.15 mg/kg/h) (10 until extubation. Ket same ketamine,...
Abstract Perception is the result of ongoing brain activity combined with sensory stimuli. In natural vision, changes in visual input typically occur as self-initiated eye movements. Nonetheless, most studies, stimuli are flashed, and movements avoided or restricted. As a consequence, neural processing associated active vision poorly understood. Here, we show that occipital event-related potentials (ERP) to during free exploration images exhibited different amplitudes, time course motor...
Summary Mechanisms underlying loss of consciousness following propofol administration remain incompletely understood. The objective this study was to compare frontal lobe electroencephalography activity and brainstem reflexes during intravenous induction general anaesthesia, in patients receiving a typical bolus dose (fast infusion) compared with slower infusion rate. We sought determine whether suppression (‘bottom‐up’) predominates over cortical function (‘top‐down’). Sixteen ASA physical...
Attention is a key cognitive phenomenon that studied to understand disorders or even estimate workloads prevent accidents. Usually, it using brain activity, though has many psychophysiological correlates. In the present study, we aim evaluate if finger temperature, as surrogate of peripheral vasoconstriction, can be used obtain similar and complementary information electroencephalography (EEG) activity measurements. To conduct this, 34 participants were recruited submitted performing four...
Purpose: Acute administration of remifentanil may lead to opioid-induced hyperalgesia (OIH). Studies in mice suggest that OIH is mediated by impaired anionic homeostasis spinal lamina I neurons due a down-regulation the K + -Cl − co-transporter KCC2, which was reverted using acetazolamide (ACTZ), carbonic anhydrase inhibitor. We propose ACTZ prevents remifentanil-mediated humans. Patients and methods: conducted randomized, double-blind, placebo-controlled clinical trial between December 2016...
Background: The electroencephalogram (EEG) may be useful for monitoring anesthetic depth and avoiding overdose. We aimed to characterize EEG-recorded brain oscillations during increasing of anesthesia in a real-life surgical scenario. hypothesized that alpha power coherency will diminish as propofol dose increases between loss consciousness (LOC) an EEG burst suppression (BS) pattern. Methods: This nonrandomized dose-response clinical trial with concurrent control included 16 patients...
Sedation in coronavirus disease 2019 (COVID-19) patients has been identified as a major challenge. We aimed to investigate whether the use of multiparameter electroencephalogram (EEG) protocol guide sedation COVID-19 would increase 30-day mechanical ventilation-free days (VFD). conducted double-blind randomized clinical trial. included with severe pneumonia due who required ventilation (MV) and deep sedation. control (n = 25) or group 25). intervention was administered following standard...
In this work we present SaFiDe, a deterministic method to detect eye movements (saccades and fixations) from eye-trace data. We developed for human nonhuman primate data video- coil-recorded traces further applied the algorithm computed electrooculograms. All analyzed were free-exploration paradigms, where main challenge was periods of saccades fixations that uncued by task. The uses velocity acceleration thresholds, calculated trace, saccade fixation periods. show our fully detects during...
Background: Pharmacological tolerance is defined as a decrease in the effect of drug over time, or need to increase dose achieve same effect. It has not been established whether repeated exposure sevoflurane induces children. Methods: We conducted an observational study children younger than 6 years age scheduled for multiple radiotherapy sessions with anesthesia. To evaluate development tolerance, we analyzed changes electroencephalographic spectral power at induction, across sessions....