Eduardo Rosales Jubal
A5103849738- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- RNA regulation and disease
- Neurological diseases and metabolism
- Neurological disorders and treatments
- Decision-Making and Behavioral Economics
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Dysphagia Assessment and Management
- Mental Health Research Topics
- Axon Guidance and Neuronal Signaling
- Nuclear Receptors and Signaling
- Biochemical and Molecular Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Alzheimer's disease research and treatments
- interferon and immune responses
- Computational Drug Discovery Methods
- Visual perception and processing mechanisms
- Neuroscience, Education and Cognitive Function
- Carbohydrate Chemistry and Synthesis
- Autophagy in Disease and Therapy
- Folate and B Vitamins Research
University of Southern California
2025
Luxembourg Institute of Health
2022-2024
Centre Hospitalier de Luxembourg
2024
Laboratoire National de Santé
2024
University of Luxembourg
2024
University Medical Center of the Johannes Gutenberg University Mainz
2014-2021
Johannes Gutenberg University Mainz
2014-2021
Focus (Germany)
2021
Diego Portales University
2015-2017
Universidad Autónoma de Chile
2017
Pupil dilation under constant illumination is a physiological marker which modulation related to several cognitive functions involved in daily decision making. There evidence for role of pupil changes during decision-making tasks associated uncertainty, reward-prediction errors and surprise. However, while some work suggests that mainly modulated by reward predictions, others point out this uncertainty signaling Supporting later hypothesis, the neural substrate noradrenaline (NA) activity...
Encoding of sensory inputs in the cortex is characterized by sparse neuronal network activation. Optogenetic stimulation has previously been combined with fMRI (ofMRI) to probe functional networks. However, for a quantitative optogenetic probing sensory-driven activation, level similarity between and activation needs be explored. Here, we complement ofMRI optic fiber-based population Ca 2+ recordings region-specific readout spiking activity rat brain. Comparing responses blood oxygenation...
Variations in human behavior correspond to the adaptation of nervous system different internal and environmental demands. Attention, a cognitive process for weighing demands, changes over time. Pupillary activity, which is affected by fluctuating levels processing, appears identify neural dynamics that relate states attention. In mice, example, pupil directly correlate with brain state fluctuations. Although, humans, alpha-band activity associated inhibitory processes cortical networks...
Background Deep phenotyping of Parkinson’s disease (PD) is essential to investigate this fastest-growing neurodegenerative disorder. Since 2015, over 800 individuals with PD and atypical parkinsonism along more than control subjects have been recruited in the frame observational, monocentric, nation-wide, longitudinal-prospective Luxembourg study. Objective To profile baseline dataset explore risk factors, comorbidities clinical profiles associated PD, controls. Methods Epidemiological...
Abstract Aberrant activity of local functional networks underlies memory and cognition deficits in Alzheimer’s disease (AD). Hyperactivity was observed microcircuits mice AD-models showing plaques, also recently early stage AD mutants prior to amyloid deposition. However, effects on cortical remain unresolved. Using two-photon calcium imaging, we found altered temporal distributions (burstiness) the spontaneous layer II/III visual cortex neurons, a mouse model familial (5xFAD), before plaque...
Brain injuries, such as stroke or trauma, induce neural stem cells in the subventricular zone (SVZ) to a neurogenic response. Very little is known about molecular cues that signal tissue damage, even over large distances, SVZ. Based on our analysis of gene expression patterns SVZ, 48 hr after an ischemic lesion caused by middle cerebral artery occlusion, we hypothesized presence injury might be transmitted astrocytic traveling calcium wave rather than diffusible factors hypoxia. Using newly...
Abstract Introduction While there is an interest in defining longitudinal change people with chronic illness like Parkinson’s disease (PD), statistical analysis of data not straightforward for clinical researchers. Here, we aim to demonstrate how the choice method may influence research outcomes, (e.g., progression apathy), specifically size effect estimates, a cohort. Methods In this retrospective 802 typical Luxembourg Parkinson's study, compared mean apathy scores at visit 1 and 8 by...
Learning under uncertainty is a common task that people face in their daily life. This process relies on the cognitive ability to adjust behavior environmental demands. Although biological underpinnings of those processes have been extensively studied, there has little work formal models seeking capture fundamental dynamic learning uncertainty. In present work, we aimed understand basic mechanisms outcome processing involved decisions and evaluate relevance previous experiences enhancing...
Abstract Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD mild cognitive impairment (MCI) have yet be comprehensively explored. We compared gut microbial features of MCI ( n = 58) cognitively unimpaired 60) 90) normal cognition. Our results did not support a specific signature in PD.
Abstract Background Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to development of severe autonomic dysfunction. One initial indicators PD is appearance dysautonomia. As such, it vital monitor and manage health individuals PD, as may have clinical implications in commonly recognized non-motor aspects disease. To study association history (CVD) occurrence severity here, we lend data CVD...