A5050128183- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Cell Image Analysis Techniques
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Gene Regulatory Network Analysis
- Receptor Mechanisms and Signaling
- Functional Brain Connectivity Studies
- Photoreceptor and optogenetics research
- Advanced Fluorescence Microscopy Techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Neuroscience and Neural Engineering
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Cancer-related gene regulation
Johannes Gutenberg University Mainz
2020-2024
University Medical Center of the Johannes Gutenberg University Mainz
2020-2024
Leibniz Institute for Resilience Research
2020-2024
Leibniz Association
2020-2024
Abstract One mechanism of particular interest to regulate mRNA fate post-transcriptionally is modification. Especially the extent m 1 A methylation highly discussed due methodological differences. However, one single site in mitochondrial ND5 was unanimously reported by different groups. a subunit complex I respiratory chain. It considered essential for coupling oxidation and proton transport. Here we demonstrate that this might be involved pathophysiology Alzheimer’s disease (AD)....
Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), and amyotrophic lateral sclerosis (ALS) are heterogeneous, progressive with frequently overlapping symptoms characterized by a loss of neurons. Studies have suggested relations between neurodegenerative for many years (e.g., regarding the aggregation toxic proteins or triggering endogenous cell death pathways). We gathered publicly available genomic, transcriptomic, proteomic data from 177...
Abstract Chronic stress has become a predominant factor associated with variety of psychiatric disorders, such as depression and anxiety, in both human animal models. Although multiple studies have looked at transcriptional changes after social defeat stress, these primarily focus on bulk tissues, which might dilute important molecular signatures interaction activated cells. In this study, we employed the Arc-GFP mouse model conjunction chronic (CSD) to selectively isolate nuclei (AN)...
Abstract Aberrant activity of local functional networks underlies memory and cognition deficits in Alzheimer’s disease (AD). Hyperactivity was observed microcircuits mice AD-models showing plaques, also recently early stage AD mutants prior to amyloid deposition. However, effects on cortical remain unresolved. Using two-photon calcium imaging, we found altered temporal distributions (burstiness) the spontaneous layer II/III visual cortex neurons, a mouse model familial (5xFAD), before plaque...
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's Huntington's and Amyotrophic Lateral Sclerosis are heterogeneous, progressive with frequently overlapping symptoms characterized by a loss of neurons. Studies suggested relations between neurodegenerative for many years, e.g., regarding the aggregation toxic proteins or triggering endogenous cell death pathways. Within this study, publicly available genomic, transcriptomic proteomic data were gathered from 188 studies more...
Abstract Summary Segmentation of neural somata is a crucial and usually the most time-consuming step in analysis optical functional imaging neuronal microcircuits. In recent years, multiple auto-segmentation tools have been developed to improve speed consistency segmentation process, mostly, using deep learning approaches. Current tools, while advanced, still encounter challenges producing accurate results, especially datasets with low signal-to-noise ratio. This has led reliance on manual...
The common features of all neurodegenerative diseases, including Alzheimer's disease, Parkinson's Amyotrophic Lateral Sclerosis (ALS), and Huntington's are the accumulation aggregated misfolded proteins progressive loss neurons, leading to cognitive decline locomotive dysfunction. Still, they differ in their ultimate manifestation, affected brain region, kind proteinopathy. In last decades, a vast number processes have been described as associated with making it increasingly harder keep an...
<title>Abstract</title> Susceptibility to chronic social stressors often results in the development of mental health disorders including major depressive and anxiety disorders. In contrast, some individuals remain resilient even after repeated stress exposure. Understanding molecular drivers behind these divergent phenotypic outcomes is crucial. However, previous studies using defeat (CSD) model have been limited by use bulk tissues investigating single omics domains. To overcome...
Abstract One mechanism of particular interest to regulate mRNA fate post-transcriptionally is modification. Especially the extent m 1 A methylation highly discussed due methodological differences. However, one single site in mitochondrial ND5 was unanimously reported by different groups. a subunit complex I respiratory chain. It considered essential for coupling oxidation and proton transport. Here we demonstrate that this might be involved pathophysiology Alzheimer’s disease (AD)....
Abstract Chronic stress has become a predominant factor associated with variety of psychiatric disorders, such as depression and anxiety, in both humans animal models. Although multiple studies have looked at transcriptional changes after social defeat stress, these mostly focus on bulk tissues, which might dilute important molecular signatures interaction activated cells. In this study, we employed the Arc-GFP mouse model conjunction chronic (CSD) to selectively isolate nuclei (AN)...
The IntelliCage systems offer the possibility to conduct long-term behavioral experiments on mice in social groups without human intervention. Although this setup provides new findings, only about 150 studies with system have been published last two decades, which is also caused by challenging problems of processing and handling large heterogeneous amounts captured data. This application note introduces Python-GUI IntelliPy, especially designed for users not very experienced using...