A5091509057- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Sleep and related disorders
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Axon Guidance and Neuronal Signaling
- Advanced Memory and Neural Computing
- Bacterial Infections and Vaccines
- Advanced MRI Techniques and Applications
- Global Health Care Issues
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Iron Metabolism and Disorders
- Healthcare Policy and Management
- Potassium and Related Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Spaceflight effects on biology
- Molecular Communication and Nanonetworks
- EEG and Brain-Computer Interfaces
- Dialysis and Renal Disease Management
- Public Health in Brazil
University of Lausanne
2023-2024
Leibniz Institute for Resilience Research
2019-2021
Johannes Gutenberg University Mainz
2014-2020
University Medical Center of the Johannes Gutenberg University Mainz
2015-2020
University of Bari Aldo Moro
2019
The University of Sydney
2019
Neurosciences Institute
2017
Spontaneous slow oscillation-associated wave activity represents an internally generated state which is characterized by alternations of network quiescence and stereotypical episodes neuronal - events. However, it remains unclear macroscopic signal related to these active periods the rhythm. We used optic fiber-based calcium recordings local neural populations in cortex thalamus detect neurophysiologically defined waves isoflurane anesthetized rats. The individual events were for...
Encoding of sensory inputs in the cortex is characterized by sparse neuronal network activation. Optogenetic stimulation has previously been combined with fMRI (ofMRI) to probe functional networks. However, for a quantitative optogenetic probing sensory-driven activation, level similarity between and activation needs be explored. Here, we complement ofMRI optic fiber-based population Ca 2+ recordings region-specific readout spiking activity rat brain. Comparing responses blood oxygenation...
Communication with the hematopoietic system is a vital component of regulating brain function in health and disease. Traditionally, major routes considered for this neuroimmune communication are by individual molecules such as cytokines carried blood, neural transmission, or, more severe pathologies, entry peripheral immune cells into brain. In addition, functional mRNA from blood can be directly transferred to neurons via extracellular vesicles (EVs), but parameters that determine their...
Parvalbumin (PV) positive interneurons exert strong effects on the neocortical excitatory network, but it remains unclear how they impact spatiotemporal dynamics of sensory processing in somatosensory cortex.Here, we characterized optogenetic inhibition and activation PV spontaneous sensory-evoked activity mouse barrel cortex vivo.Inhibiting led to a broad-spectrum power increase both activity.Whisker-evoked responses were significantly increased within 20 ms after stimulus onset during...
Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory behavior studies. Devices capable of both recording brain-computer interfaces (BCIs) should ideally operate un-tethered allow chronic longitudinal manipulations the freely moving animal. In this study, we designed new intracortical BCI feasible telemetric stimulating local gray white matter visual neural circuit after irradiation exposure. To increase translational reliance, put forward...
Precise connection of thalamic barreloids with their corresponding cortical barrels is critical for processing vibrissal sensory information. Here, we show that PRG-2, a phospholipid-interacting molecule, important thalamocortical axon guidance. Developing fibers both in PRG-2 full knockout (KO) and thalamus-specific KO mice prematurely entered the plate, eventually innervating non-corresponding barrels. This misrouting relied on lost axonal sensitivity toward lysophosphatidic acid (LPA),...
Abstract Hypocretin/orexin neurons are essential to stabilize sleep, but the underlying mechanisms remain elusive. We report that hypocretin of perifornical hypothalamus highly active during rapid eye movement sleep and show state-specific correlation with noradrenergic neurons. Deletion gene significantly increased periodic reactivations locus coeruleus dysregulated their activity across transitions, suggesting a role for in mediating neuromodulation sleep.
Abstract Communication with the hematopoietic system is a vital component of regulating brain function in health and disease. Traditionally, major routes considered for this neuroimmune communication are either by individual molecules such as cytokines carried blood, neural transmission, or more severe pathologies, entry peripheral immune cells into brain. In addition, functional mRNA from blood can be directly transferred to neurons via extracellular vesicles (EVs) but parameters that...