Marijus Giraitis
A5093326019- Parkinson's Disease Mechanisms and Treatments
- Balance, Gait, and Falls Prevention
- Neurological disorders and treatments
- Advanced Computing and Algorithms
- Cystic Fibrosis Research Advances
- Folate and B Vitamins Research
- Neurological diseases and metabolism
- Cellular transport and secretion
- Autophagy in Disease and Therapy
- Advanced Causal Inference Techniques
- Lysosomal Storage Disorders Research
- Gut microbiota and health
- Dysphagia Assessment and Management
- Carbohydrate Chemistry and Synthesis
- RNA regulation and disease
- Nuclear Receptors and Signaling
- Heart Rate Variability and Autonomic Control
- Biochemical and Molecular Research
- MicroRNA in disease regulation
University of Luxembourg
2024
Luxembourg Institute of Health
2023-2024
Centre Hospitalier de Luxembourg
2023-2024
Maastricht University Medical Centre
2024
Abstract Parkinson’s disease (PD) is a highly heterogeneous disorder influenced by several environmental and genetic factors. Effective disease-modifying therapies robust early-stage biomarkers are still lacking, an improved understanding of the molecular changes in PD could help to reveal new diagnostic markers pharmaceutical targets. Here, we report results from cohort-wide blood plasma metabolic profiling patients controls Luxembourg Study detect disease-associated alterations at level...
Abstract MicroRNAs act via targeted suppression of messenger RNA translation in the DNA–RNA–protein axis. The dysregulation microRNA(s) reflects epigenetic changes affecting cellular processes multiple disorders. To understand complex effect dysregulated microRNAs linked to neurodegeneration, we performed a cross-sectional microRNA expression analysis idiopathic Parkinson's disease (n = 367), progressive supranuclear palsy 35) and healthy controls 416) from Luxembourg Study, followed by...
Abstract Heterozygous variants in the glucocerebrosidase GBA1 gene are an increasingly recognized risk factor for Parkinson’s disease (PD). Due to GBAP1 pseudogene, which shares 96% sequence homology with coding region, accurate variant calling by array-based or short-read sequencing methods remains a major challenge understanding genetic landscape of -associated PD. We analyzed 660 patients PD, 100 Parkinsonism and 808 healthy controls from Luxembourg study, sequenced using amplicon-based...
Background Deep phenotyping of Parkinson’s disease (PD) is essential to investigate this fastest-growing neurodegenerative disorder. Since 2015, over 800 individuals with PD and atypical parkinsonism along more than control subjects have been recruited in the frame observational, monocentric, nation-wide, longitudinal-prospective Luxembourg study. Objective To profile baseline dataset explore risk factors, comorbidities clinical profiles associated PD, controls. Methods Epidemiological...
Abstract Introduction While there is an interest in defining longitudinal change people with chronic illness like Parkinson’s disease (PD), statistical analysis of data not straightforward for clinical researchers. Here, we aim to demonstrate how the choice method may influence research outcomes, (e.g., progression apathy), specifically size effect estimates, a cohort. Methods In this retrospective 802 typical Luxembourg Parkinson's study, compared mean apathy scores at visit 1 and 8 by...
Abstract Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD mild cognitive impairment (MCI) have yet be comprehensively explored. We compared gut microbial features of MCI ( n = 58) cognitively unimpaired 60) 90) normal cognition. Our results did not support a specific signature in PD.
Abstract Background Parkinson's disease (PD), while often associated with its distinctive motor symptoms, can also exert a notable impact on the cardiovascular system due to development of severe autonomic dysfunction. One initial indicators PD is appearance dysautonomia. As such, it vital monitor and manage health individuals PD, as may have clinical implications in commonly recognized non-motor aspects disease. To study association history (CVD) occurrence severity here, we lend data CVD...