A5082864198- Ethics in Clinical Research
- Research Data Management Practices
- Plant-Microbe Interactions and Immunity
- Parkinson's Disease Mechanisms and Treatments
- Cancer Genomics and Diagnostics
- Privacy, Security, and Data Protection
- Privacy-Preserving Technologies in Data
- Data Quality and Management
- Radiomics and Machine Learning in Medical Imaging
- Digital Rights Management and Security
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Scientific Computing and Data Management
- Legume Nitrogen Fixing Symbiosis
- Microbial Community Ecology and Physiology
- Forest Insect Ecology and Management
- Law, AI, and Intellectual Property
- CRISPR and Genetic Engineering
- Telecommunications and Broadcasting Technologies
- European Criminal Justice and Data Protection
- Nuclear Physics and Applications
- Genetically Modified Organisms Research
- Nematode management and characterization studies
- Advanced Radiotherapy Techniques
- COVID-19 Digital Contact Tracing
Eurostat
2023-2024
University of Luxembourg
2010-2024
Luxembourg Institute of Health
2024
Leibniz Centre for Agricultural Landscape Research
2006-2022
LMU Klinikum
2022
Ludwig-Maximilians-Universität München
2022
University of Bremen
2017
European University Institute
2017
Helmholtz Centre for Infection Research
2009-2011
Forschungszentrum Jülich
1997
Parkinson's disease (PD) is a systemic clinically defined by the degeneration of dopaminergic neurons in brain. While alterations gut microbiome composition have been reported PD, their functional consequences remain unclear. Herein, we addressed this question an analysis stool samples from Luxembourg Study (n = 147 typical PD cases, n 162 controls).All individuals underwent detailed clinical assessment, including neurological examinations and neuropsychological tests followed self-reporting...
Plant-associated Stenotrophomonas isolates have great potential for plant growth promotion, especially under stress conditions, due to their ability promote tolerance abiotic stresses such as salinity or drought. The endophytic strain sp. 169, isolated from a field-grown poplar, increased the of inoculated in vitro plants, with particular effect on root development, and was able stimulate rooting poplar cuttings greenhouse. produced high amounts growth-stimulating hormone auxin conditions....
Abstract Parkinson’s disease (PD) is a highly heterogeneous disorder influenced by several environmental and genetic factors. Effective disease-modifying therapies robust early-stage biomarkers are still lacking, an improved understanding of the molecular changes in PD could help to reveal new diagnostic markers pharmaceutical targets. Here, we report results from cohort-wide blood plasma metabolic profiling patients controls Luxembourg Study detect disease-associated alterations at level...
The bacterial community composition in soil and rhizosphere taken from arable field sites, differing parent material texture, was analyzed using terminal restriction fragment length polymorphism (T-RFLP) of 16S rRNA genes. Nine sandy to silty soils North-East Germany could clearly be distinguished each other, with a relatively low heterogeneity the structure within replicates. There relationship between material, i.e. different glacial aeolian sediments, clustering profiles sites. A...
In the last few years, alarming spread of Hymenoscyphus fraxineus, causal agent ash dieback, has resulted in a substantial threat to native stands central and northern Europe. Since leaves leaf petioles are primary infection sites, phyllosphere microorganisms presumed interact with pathogen discussed as source biocontrol agents. We studied compound from susceptible visible infection-free trees four high likelihood assess possible variation bacterial microbiota, depending on health status...
Abstract The General Data Protection Regulation (GDPR) of the European Union, which became applicable in 2018, contains a new accountability principle. Under this principle, controllers (ie parties determining purposes and means processing personal data) are responsible for ensuring demonstrating overall compliance with GDPR. However, interpretive uncertainties GDPR mean that must exercise considerable judgement designing implementing an appropriate strategy, making both complex...
Abstract Improving patient care and advancing scientific discovery requires responsible sharing of research data, healthcare records, biosamples, biomedical resources that must also respect applicable use conditions. Defining a standard to structure manage these conditions is complex challenging task. This exemplified by near unlimited range asset types, high variability conditions, differing applications at the individual or collective level. Furthermore, specifics granularity required are...
Abstract MicroRNAs act via targeted suppression of messenger RNA translation in the DNA–RNA–protein axis. The dysregulation microRNA(s) reflects epigenetic changes affecting cellular processes multiple disorders. To understand complex effect dysregulated microRNAs linked to neurodegeneration, we performed a cross-sectional microRNA expression analysis idiopathic Parkinson's disease (n = 367), progressive supranuclear palsy 35) and healthy controls 416) from Luxembourg Study, followed by...
The invasive ascomycete Hymenoscyphus fraxineus has been threatening Fraxinus excelsior populations throughout Europe for over two decades. Since the infection and first colonisation by pathogen occurs in leaves, leaf-colonising microorganisms have discussed as a barrier possible biocontrol agents against disease. To identify fungal groups with health-supporting potential, we compared microbiota of compound leaves from susceptible tolerant ash trees four stands high H. exposure. communities...
Researchers must collaborate globally to rapidly respond the COVID-19 pandemic. In Europe, General Data Protection Regulation (GDPR) regulates processing of personal data, including health data value researchers. Even during a pandemic, research still requires legal basis for sensitive additional justification its processing, and any transfer outside Europe. The GDPR does provide grounds derogations that can support addressing if activities are proportionate aim pursued accompanied by...
Abstract Heterozygous variants in the glucocerebrosidase GBA1 gene are an increasingly recognized risk factor for Parkinson’s disease (PD). Due to GBAP1 pseudogene, which shares 96% sequence homology with coding region, accurate variant calling by array-based or short-read sequencing methods remains a major challenge understanding genetic landscape of -associated PD. We analyzed 660 patients PD, 100 Parkinsonism and 808 healthy controls from Luxembourg study, sequenced using amplicon-based...
Several phenotypic differences observed in Parkinson's disease (PD) patients have been linked to age at onset (AAO). We endeavoured find out whether these are due the ageing process itself by using a combined dataset of idiopathic PD (n = 430) and healthy controls (HC; n 556) excluding carriers known PD-linked genetic mutations both groups. found several significant effects AAO on motor non-motor symptoms PD, but when comparing with HC (using assessment, AAA), only positive associations AAA...
The rhizosphere and phyllosphere microbial communities of transgenic potatoes producing fructan were studied in comparison with isogenic controls conventional varieties a field release experiment over period 3 years. Population densities 16S rRNA gene-based terminal restriction fragment length polymorphism (T-RFLP) analysis the bacterial community only displayed influence annual seasonal effects heterogeneity. In contrast, T-RFLP bacteria revealed two years significant differences structure...
The persistence of traits introduced into the indigenous bacterial community poplar plants was investigated using bioluminescence mediated by luc gene. Three endophytic strains provided with IncP-1α plasmid RP4-Tn-luc were used to inoculate cuttings at different phenological stages. Screening isolates and real-time PCR detection gene revealed stable for least 10 weeks. Although inoculated became established a high population density after inoculation leaf development (April) senescence...
Some European ash trees show tolerance towards dieback caused by the invasive pathogen Hymenoscyphus fraxineus. The microbiome of these harbours a range specific bacterial groups. One groups belonging to species Aureimonas altamirensis was studied in detail genome analysis and plant inoculation trial. strain group shown be phylogenetically distinct from clinical isolates 16S rRNA phylogenomics. Genome representative C2P003 resulted large number unique gene sequences comparison other...
Abstract Contemporary biomedical research heavily relies on secondary use of personal health data that were obtained in a different clinical or setting. Under the European Union’s General Data Protection Regulation ( GDPR ), controllers processing must comply with principle purpose limitation, which restricts further beyond for initially collected. However, “further processing” is not explicitly defined, resulting considerable interpretive ambiguities as to whether “secondary use” by...
Abstract Background The new European legislation on data protection, namely, the General Data Protection Regulation (GDPR), has introduced comprehensive requirements for documentation about processing of personal as well informing subjects its use. GDPR's accountability principle requires institutions, projects, and hubs to document their processings demonstrate compliance with GDPR. In response this requirement, we see emergence commercial data-mapping tools, institutions creating GDPR...