A5057705571- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Exercise and Physiological Responses
- Sports Performance and Training
- Tactile and Sensory Interactions
- Ergonomics and Musculoskeletal Disorders
- Cardiovascular and exercise physiology
- Botulinum Toxin and Related Neurological Disorders
- Diet and metabolism studies
- Olfactory and Sensory Function Studies
- Ophthalmology and Visual Impairment Studies
- Multisensory perception and integration
- Occupational Health and Performance
- Health and Medical Studies
- Restless Legs Syndrome Research
- Neurological diseases and metabolism
- Health, Environment, Cognitive Aging
- Retinal Diseases and Treatments
- Cognitive and developmental aspects of mathematical skills
- Children's Physical and Motor Development
- Gaze Tracking and Assistive Technology
- Sleep and Wakefulness Research
- Autism Spectrum Disorder Research
- Nuclear Receptors and Signaling
- Neurobiology of Language and Bilingualism
Ministère de l’Éducation nationale, de l’Enfance et de la Jeunesse
2025
University of Luxembourg
2016-2021
Centre Hospitalier de Luxembourg
2010-2019
James Madison University
2005-2008
Parkinson's disease (PD) is a systemic clinically defined by the degeneration of dopaminergic neurons in brain. While alterations gut microbiome composition have been reported PD, their functional consequences remain unclear. Herein, we addressed this question an analysis stool samples from Luxembourg Study (n = 147 typical PD cases, n 162 controls).All individuals underwent detailed clinical assessment, including neurological examinations and neuropsychological tests followed self-reporting...
While genetic advances have successfully defined part of the complexity in Parkinson's disease (PD), clinical characterization phenotypes remains challenging. Therapeutic trials and cohort studies typically include patients with earlier stages exclude comorbidities, thus ignoring a substantial real-world PD population. To account for these limitations, we implemented Luxembourg study as comprehensive clinical, molecular device-based approach including typical atypical parkinsonism,...
Previous research estimated a prevalence of 3.4% Cerebral Visual Impairment (CVI)-related visual problems within primary school children, potentially compromising students' performance. This study aimed to clarify how CVI-related difficulties relate academic performance in standardized achievement tests. As part the Luxembourg monitoring programme, 1129 first graders (mean age 7 years) participated three competence tests (mathematics, early literacy and listening comprehension) student...
This study explored the secondary use of Luxembourg's school monitoring tool for a large-scale screening Cerebral Visual Impairment (CVI)-related difficulties. 44 items, with and without time constraint, were developed, pretested among 959 children. All children subsequently participated in an individual evaluation higher-level visual processing (HLVP) measures related CVI. A clinical outcome was attributed post hoc 32 being classified as having CVI-related To explore predictive power CVI...
BackgroundIn early stages of idiopathic Parkinson's disease (IPD), lower order vision (LOV) deficits including reduced colour and contrast discrimination have been consistently reported. Data are less conclusive concerning higher (HOV) deficits, especially for facial emotion recognition (FER). However, a link between both visual levels has hypothesized.ObjectiveTo screen impairment in IPD.MethodsWe prospectively recruited 28 IPD patients with duration 1.4 +/− 0.8 years 25 healthy controls....
The objective of this study was to evaluate the discriminative power different nonmotor signs for early diagnosis Parkinson's disease (PD). Thirty patients with PD ≤3 years duration were compared 30 healthy controls. Six deficit domains (DD) defined: hyposmia, sleep abnormalities, dysautonomia, visual deficits, executive dysfunction, and depression. Plotting Receiver operating characteristic (ROC) curves exact conditional logistic modeling, followed by manual stepwise descending procedure...
Polysomnography (PSG) data are rare in patients who have early stage idiopathic Parkinson's disease (IPD).Thirty-three had IPD with a duration ≤ 3 years and 37 age-matched controls were recruited. PSG analysis was performed on current medication.Patients reduced mean percentage of muscle atonia during rapid eye movement (REM) sleep (80% vs 93%; P < 0.05). Total time, efficiency, indices/hour arousals, awakenings, apnea/hypopnea, periodic leg movements similar both groups. Age, but not...
Trekking poles are used by hikers for improved stability and lowered leg fatigue due to increased upper body muscle involvement. However, the weight of exaggerated movement when using may increase total energy expenditure at a given walking speed. Few studies have investigated physiological responses hiking with trekking outside laboratory setting. The purposes this study were determine if altered on varied terrain, whether between trials dependent grade terrain. Fourteen recreational...
OPINION article Front. Aging Neurosci., 27 May 2016Sec. Parkinson's Disease and Aging-related Movement Disorders Volume 8 - 2016 | https://doi.org/10.3389/fnagi.2016.00121
Introduction: The Munich Dysphagia Test for Parkinson’s disease (MDT-PD) was initially developed and validated in the German population as a highly sensitive specific self-reported screening questionnaire to detect early oropharyngeal symptoms aspiration risk patients with idiopathic (iPD). In order make this tool accessible prevention French speaking populations worldwide, we performed first translation provide linguistic psychometric validation unique multilingual environment of Luxembourg...
Background: Non-motor symptoms (NMS) of various anatomical origins are seen in early stage idiopathic Parkinson’s disease (IPD). Objective: To analyse when and how NMS linked together at this the disease. Methods: Prospective study recruiting 64 IPD patients with ≤3 years duration 71 age-matched healthy controls (HC). were clustered 7 non-motor domains (NMD): general cognition, executive function, visuospatial autonomic olfaction, mood, sleep. Correlation coefficients ≥|0.3| considered as...
Background: To establish the frequency of impulse control disorder (ICD) in Parkinson's disease (PD). Methods: Within Luxembourg Study, PD patients were evaluated for ICD presence (score ≥ 1 on MDS-UPDRS I item 1.6), use dopamine agonists (DA) and other medications. Results: 470 enrolled. Among 217 without DA use, 6.9% scored positive ICD, vs. 15.4% among 253 with ( p = 0.005). The regression analysis showed that age at diagnosis had only a minor impact occurrence, while there was no...
Cerebral vision impairment (CVI) refers to a disturbance in visual processing related damage the areas brain and/or pathways. It is often assumed that CVI underlies functional difficulties. Previous research estimated around 3% of mainstream educated elementary school children have CVI, potentially compromising these students’ performance. This study aimed clarify how impacts children’s performance competence tests. As part Luxembourgish monitoring, complete cohort first graders (N = 5536)...
Abstract Objective Cognitive-driven activity of daily living (ADL) impairment in Parkinson’s disease (PD) is increasingly discussed as prodromal marker for dementia. Diagnostic properties assessments this specific ADL are sparsely investigated PD. The ability the Functional Activities Questionnaire (FAQ) differentiating between PD patients with normal cognition and mild cognitive (PD-MCI), according to informant self-reports, was examined. Global function groups without compared different...
Trekking poles are used by many hikers for the putative benefits of increased stability and lowered leg fatigue due to upper body muscle involvement. However, extra weight poles, exaggerated movement when using may increase total energy expenditure at a given walking speed. Few studies have investigated physiological responses hiking with trekking outside laboratory setting. PURPOSE The purpose this study was determine if altered on varied terrain. A secondary between trials were dependent...
Trekking poles are used by many hikers for the putative benefits of increased stability and lowered leg fatigue due to upper body muscle involvement. However, extra weight poles, exaggerated movement when using may increase total energy expenditure at a given walking speed. Few studies have investigated physiological responses hiking with trekking outside laboratory setting. PURPOSE The purpose this study was determine if altered on varied terrain. A secondary between trials were dependent...