A5024445779- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Bioinformatics and Genomic Networks
- Renal cell carcinoma treatment
- Genomics and Phylogenetic Studies
- Reproductive Biology and Fertility
- Molecular Biology Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Parkinson's Disease Mechanisms and Treatments
- Advanced Proteomics Techniques and Applications
- Advanced Breast Cancer Therapies
- Biomedical Text Mining and Ontologies
- Diet and metabolism studies
- Gene expression and cancer classification
- PI3K/AKT/mTOR signaling in cancer
- Information Systems Theories and Implementation
- Gut microbiota and health
- Genetic factors in colorectal cancer
- Tuberous Sclerosis Complex Research
- Cancer-related Molecular Pathways
- Innovative Approaches in Technology and Social Development
- Genomics and Rare Diseases
- Innovation, Technology, and Society
- Biotin and Related Studies
Utrecht University
2019-2023
Institut für Angewandte Trainingswissenschaft
2023
Oncode Institute
2020-2022
University Medical Center Utrecht
2019-2022
Leipzig University
2022
University of Amsterdam
2013-2017
University of Luxembourg
2017
Parkinson's disease (PD) is a systemic clinically defined by the degeneration of dopaminergic neurons in brain. While alterations gut microbiome composition have been reported PD, their functional consequences remain unclear. Herein, we addressed this question an analysis stool samples from Luxembourg Study (n = 147 typical PD cases, n 162 controls).All individuals underwent detailed clinical assessment, including neurological examinations and neuropsychological tests followed self-reporting...
Here, we present a mouse brain protein atlas that covers 17 surgically distinct neuroanatomical regions of the adult brain, each less than 1 mm3 in size. The expression levels are determined for 6,500 to 7,500 gene products from region and over 12,000 entire documenting physiological repertoire proteins an anatomically resolved comprehensive manner. We explored utility our spatially defined profiling methods model Parkinson's disease. compared proteome vulnerable (substantia nigra pars...
Accurate detection of somatic structural variation (SV) in cancer genomes remains a challenging problem. This is part due to the lack high-quality, gold-standard datasets that enable benchmarking experimental approaches and bioinformatic analysis pipelines. Here, we performed SV paired melanoma normal lymphoblastoid COLO829 cell lines using four different sequencing technologies. Based on evidence from multiple technologies combined with extensive validation, compiled comprehensive set...
Adult granulosa cell tumors (AGCTs) harbor a somatic FOXL2 c.402C>G mutation in ~95% of cases and are mainly surgically removed due to limited systemic treatment effect. In this study, potentially targetable genomic alterations AGCTs were investigated by whole genome sequencing on 46 tumor samples matched normal DNA. Copy number variant (CNV) analysis confirmed gain chromosome 12 14, loss 22. Pathogenic TP53 mutations identified three patients with highest mutational burden mitotic...
The majority of patients with ovarian cancer ultimately develop recurrent chemotherapy-resistant disease. Treatment stratification is mainly based on histological subtype and stage, prior response to platinum-based chemotherapy, time Here, we integrated clinical treatment, treatment response, survival data whole-genome sequencing profiles 132 solid tumor biopsies metastatic epithelial explore genome-informed opportunities. Samples from primary disease harbored comparable numbers single...
Abstract Accurate detection of somatic structural variation (SV) in cancer genomes remains a challenging problem. This is part due to the lack high-quality gold standard datasets that enable benchmarking experimental approaches and bioinformatic analysis pipelines for comprehensive SV detection. Here, we approached this challenge by genome-wide paired melanoma normal lymphoblastoid COLO829 cell lines using four different technologies: Illumina HiSeq, Oxford Nanopore, Pacific Biosciences 10x...
Protein–protein interactions in cells are widely explored using small–scale experiments. However, the search for protein complexes and their data from high throughput experiments such as immunoprecipitation is still a challenge. We present "4N", novel method detecting data. Our heuristic algorithm based on Near Neighbor Network (3N) clustering. It written R, it faster than model-based methods, has only small number of tuning parameters. explain application our new to real results two...
Adult granulosa cell tumor (AGCT) is a rare ovarian cancer subtype, with peak incidence around 50–55 years. Although AGCT can occur in specific syndromes, genetic predisposition for has not been identified. The aim of this study to identify variant families patients, potentially contributing evolution. We identified four families, each including two women diagnosed AGCT. Whole-genome sequencing was performed overlapping germline variants or affected genes. Familial relationship evaluated...
Abstract Adult granulosa cell tumors (AGCTs) harbor a somatic FOXL2 c.402C>G mutation in ∼95% of cases and are mainly surgically removed due to limited systemic treatment effect. In this study, potentially targetable genomic alterations AGCTs were investigated by whole genome sequencing on 46 tumor samples matched normal DNA. Copy number variant (CNV) analysis confirmed gain chromosome 12 14, loss 22. Pathogenic TP53 mutations identified three patients with highest mutational burden...
Protein interaction in cells can be described at different levels. At a low level, proteins function together small, stable complexes and higher sets of interacting complexes. All levels are crucial for the living organism, one challenges proteomics is to measure their One common method such measurements immunoprecipitation followed by mass spectrometry (IP/MS), which has potential probe protein forms. However, IP/MS data complex because proteins, diverse forms, manifest themselves ways...
5516 Background: Ovarian cancer is globally the second most common cause of death among women with gynecologic malignancies. Despite high initial response rates, overall prognosis this patient population remains poor. The majority advanced ovarian cancers will become platinum resistant defined by recurrence within six months after completion therapy. In first part current phase II study, combination carboplatin and Wee1 inhibitor adavosertib (AZD1775), showed to be safe effective in patients...
<h3>Introduction/Background</h3> While most patients with ovarian cancer are initially sensitive to chemotherapy, approximately 75% will develop recurrent disease and become resistant. Predicted response platinum is considered important in deciding on the best treatment upon recurrence. Often a disease-free interval of 6 months threshold between predicted resistance sensitivity. In this study we compare clinical response, aim identify mechanisms chemotherapy through whole genome sequencing...
Abstract The majority of patients with ovarian cancer ultimately develop recurrent chemotherapy resistant disease. Treatment stratification is mainly based on histological subtype and stage, prior response to platinum-based time Here, we integrated clinical treatment, treatment survival data whole genome sequencing profiles 132 solid tumor biopsies metastatic epithelial explore genome-informed opportunities. Samples from primary disease harbored comparable numbers single nucleotide variants...