A5026924735- Respiratory viral infections research
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Infectious Encephalopathies and Encephalitis
- Pneumonia and Respiratory Infections
- interferon and immune responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Birth, Development, and Health
- Viral Infections and Vectors
- Chemokine receptors and signaling
- Diabetes and associated disorders
- Thyroid Disorders and Treatments
- Long-Term Effects of COVID-19
- Congenital Diaphragmatic Hernia Studies
- Immune responses and vaccinations
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Parvovirus B19 Infection Studies
- Systemic Lupus Erythematosus Research
- Bacterial Infections and Vaccines
- RNA regulation and disease
- COVID-19 Impact on Reproduction
- Herpesvirus Infections and Treatments
Millennium Institute on Immunology and Immunotherapy
2014-2024
Pontificia Universidad Católica de Chile
2015-2024
Universidad Autónoma de Chile
2024
US Biologic (United States)
2014
Universidad Andrés Bello
2009
Respiratory syncytial virus (RSV) is the major cause of respiratory illness in infants worldwide. Neurologic alterations, such as seizures and ataxia, have been associated with RSV infection. We demonstrate presence proteins RNA zones brain—such hippocampus, ventromedial hypothalamic nucleus, brainstem—of infected mice. One month after disease resolution, rodents showed behavioral cognitive impairment marble burying (MB) Morris water maze (MWM) tests. Our data indicate that learning caused...
Background:Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is a live attenuated vaccine mainly administered to newborns and used for over 100 years prevent the disease caused by Mycobacterium tuberculosis (M. tb). This can induce immune response polarization towards Th1 profile, which desired counteracting M. tb, other mycobacteria, unrelated intracellular pathogens. The BCG has been as vector express recombinant proteins shown protect against several diseases, particularly respiratory...
Background The prevalence of autism spectrum disorder (ASD) has significantly risen in the past three decades, prompting researchers to explore potential contributions environmental factors during pregnancy ASD development. One such factor interest is gestational hypothyroxinemia (HTX), a frequent condition associated with cognitive impairments offspring. While retrospective human studies have linked HTX autistic traits, cellular and molecular mechanisms underlying development ASD-like...
Abstract Human respiratory syncytial virus infection is a leading cause of pediatric morbidity and mortality. A previous murine study showed that during severe acute infections the invades central nervous system, infected animals evolve with long-lasting learning difficulties associated long-term potentiation impairment in their hippocampus. We hypothesized here human infants who presented episode before 6 months age would develop difficulties. measured acquisition native phoneme repertoire...
Background: Papillary thyroid cancer (PTC), the most prevalent type of differentiated carcinoma, displays a strikingly high frequency lymph node metastasis (LNM). Recent data suggest that chemokines can play an important role in promoting tumor progression and metastatic migration cells. Here we have evaluated whether PTC tissues express different pattern chemokine receptors if expression these correlates with LNM. Methods: We assessed by immunohistochemistry flow cytometry CCR3, CCR7, CXCR4...
// Soledad Urra 1 , Martin C. Fischer José R. Martínez Loreto Véliz 2 Paulina Orellana Antonieta Solar 3 Karen Bohmwald 4 Alexis Kalergis 4, 5 Claudia Riedel 6 Alejandro H. Corvalán 7 Juan Roa Rodrigo Fuentealba 8 Joaquin Cáceres 9 Marcelo López-Lastra Augusto León Nicolás Droppelmann and Hernán E. González 1, Department of Surgical Oncology, Faculty Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile Physiology, Biological Sciences, Pathology, Millennium Institute on...