A5001413374- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Sarcoma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Neuroendocrine Tumor Research Advances
- Thyroid Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
- Soft tissue tumor case studies
- Neuroblastoma Research and Treatments
- Genetic factors in colorectal cancer
- Spondyloarthritis Studies and Treatments
- Cardiac tumors and thrombi
- Parathyroid Disorders and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Tumors and Oncological Cases
- Lung Cancer Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Cancer Risks and Factors
- Chemokine receptors and signaling
- Multiple and Secondary Primary Cancers
- Occupational and environmental lung diseases
Pontificia Universidad Católica de Chile
2012-2025
University College London
2018
Washington Center
2013
University of California, San Francisco
2008
Hospital San Juan de la Cruz
2008
The University of Texas MD Anderson Cancer Center
2005
Fondo Nacional de Desarrollo Científico y Tecnológico
2005
Pathological Society
2004
The hindfoot is an uncommon site for malignant tumours. While limb salvage procedures are now more common treating bone sarcoma, there limited information available on reconstruction alternatives because of its low incidence and challenging outcomes. We present a case report man in his late 60s with synovial sarcoma affecting the right heel (calcaneus soft tissue). A wide resection was performed, followed by using femoral head allograft while preserving subtalar joint Achilles tendon...
Obese Zucker rats (ZR) have been used as an experimental model for non-alcoholic fatty liver disease and are particularly susceptible to various types of injury. Bile secretory function has not assessed in ZR.To study bile secretion expression the main hepatobiliary transporters ZR.Bile flow biliary lipids glutathione were determined eight 14 week old obese ZR their lean controls. Protein mass mRNA Na(+)/taurocholate cotransporting polypeptide (Ntcp), salt export pump (Bsep), multidrug...
In most of the world, diagnostic surgery remains frequent approach for indeterminate thyroid cytology. Although several molecular tests are available testing in centralized commercial laboratories United States, there no kits local laboratory testing. The aim this study was to develop a prototype vitro (IVD) gene classifier further characterization nodules with an cytology.In first stage, expression 18 genes determined by quantitative polymerase chain reaction (qPCR) broad histopathological...
Background: Although most thyroid nodules with indeterminate cytology are benign, in of the world, surgery remains as frequent diagnostic approach. We have previously reported a 10-gene genetic classifier, which accurately predicts benign nodules. The assay is prototype kit suitable for reference laboratory testing and could potentially avoid unnecessary patients cytology. Methods: Classifier performance was tested two independent, ethnically diverse, prospective multicenter trials...
Molecular testing contributes to improving the diagnosis of indeterminate thyroid nodules (ITNs). ThyroidPrint® is a ten-gene classifier aimed rule out malignancy in ITN. Post-validation studies are necessary determine real-world clinical benefit patients with A single-center, prospective, noninterventional utility study was performed, analyzing impact physicians' decisions for Demographics, nodule characteristics, benign call rates (BCRs), and surgical outcomes were measured....
Although 0.3% of melanomas occur in children, the incidence has risen past decades. In adult melanoma, some chromosomal regions 1p, 6q, 9p, 10q, and 11q are frequently deleted. Microsatellite instability (MSI), which reflects impaired DNA repair, been found at low levels melanoma melanocytic nevi. To investigate molecular changes pediatric a screening for loss heterozygosity microsatellite was performed compared with melanoma. Formalin-fixed, paraffin-embedded tissues from 10 melanomas, 9...
// Soledad Urra 1 , Martin C. Fischer José R. Martínez Loreto Véliz 2 Paulina Orellana Antonieta Solar 3 Karen Bohmwald 4 Alexis Kalergis 4, 5 Claudia Riedel 6 Alejandro H. Corvalán 7 Juan Roa Rodrigo Fuentealba 8 Joaquin Cáceres 9 Marcelo López-Lastra Augusto León Nicolás Droppelmann and Hernán E. González 1, Department of Surgical Oncology, Faculty Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile Physiology, Biological Sciences, Pathology, Millennium Institute on...
Objective: After initial treatment, up to 30% of patients with papillary thyroid cancer (PTC) have incomplete response, mainly cervical lymph node (LN) disease. Previous studies suggested that active surveillance (AS) is a possible option for these patients. Our aim was report the results AS in PTC and LN Materials methods: In this retrospective observational study, we included adult treated followed PTC, who presented disease [...]
Steroidogenic acute regulatory protein (StAR) plays a crucial role in the transport of cholesterol from cytoplasm to inner mitochondrial membrane, facilitating its conversion pregnenolone by cytochrome P450scc. Its essential steroidogenesis was demonstrated after observing that StAR gene mutations gave rise potentially lethal disease named congenital lipoid adrenal hyperplasia, which virtually no steroids are produced. We report here 2-month-old female patient, karyotype 46XY, who presented...
The thyroid nodule is a frequent cause of primary care consultation. prevalence palpable approximately 4-7%, increasing up to 67% by the incidental detection nodules on ultrasound. vast majority are benign and asymptomatic, staying stable over time. clinical importance studying exclude cancer, which occurs in 5 10% nodules. Board SOCHED (Chilean Society Endocrinology Diabetes) asked Thyroid Study Group develop consensus regarding diagnostic management Chile, aimed at non-specialist...
Fibrous dysplasia, including McCune-Albright syndrome, is a genetic, non-inheritable benign bone disorder that may involve single or multiple bone, typically occurring in the diaphysis metaphysis of long bones. In very rare instances polyostotic fibrous dysplasia present involvement epiphysis Aneurysmal cysts are benign, expansile, lytic lesions formed by cystic cavities containing blood, occur de novo secondary to other dysplasia. We report case an 18-year-old female with (McCune-Albright...
Parathyroid carcinoma is a rare malignant disease that presents as sporadic or familial primary hyperparathyroidism (PHP). The latter associated with some genetic syndromes. It occurs equal frequency in both sexes, unlike PHP caused by parathyroid adenoma more common women. should be suspected cases of severe hypercalcemia, high hormone levels and palpable cervical mass. Given the difficulty distinguishing between prior to surgery, diagnosis often made after parathyroidectomy. only curative...
Clinical features of 17 patients with familial non medullary thyroid carcinomaBackground: Papillary carcinoma can have aggregation.Aim: To compare retrospectively (FNMTC) sporadic papillary (PTC).Material and methods: Retrospective analysis medical records carcinoma.An index case was defined as a subject the diagnosis differentiated one or more first degree relatives same type cancer.Seventeen such were identified compared 352 subjects PTC.Results: The most common affected sisters.Patients...