A5002339575- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- HER2/EGFR in Cancer Research
- Global Cancer Incidence and Screening
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- Cancer and Skin Lesions
- Genomic variations and chromosomal abnormalities
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Genomics and Chromatin Dynamics
- Thyroid Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Cancer-related gene regulation
- Innovations in Medical Education
- MicroRNA in disease regulation
- Inflammatory Biomarkers in Disease Prognosis
- DNA Repair Mechanisms
- PARP inhibition in cancer therapy
- Head and Neck Anomalies
University of California, Davis
2024
Pontificia Universidad Católica de Chile
2014-2023
Sociedad de Biología de Chile
2012
Centre Hospitalier Universitaire de Poitiers
2011
AbstractGermline mutations in BRCA1 account for a low proportion of hereditary cases diverse populations. Several efforts have been made to find new genes involved the inheritance breast cancer with no success until today. The participation development has proposed several studies where hypermethylation its promoter and decrease expression reported sporadic one study on familial cases. To explore carcinogenesis through different mechanism than germline mutations, we studied methylation...
To determine the frequency of occult macroscopic metastasis detected by preoperative US evaluation neck in patients with PTC. Papillary thyroid carcinoma (PTC) is a malignancy high rate lymph node metastasis. The findings routine ultrasonography (US) and physical examination may underestimate metastatic disease. Thus, we propose that diagnosed as having PTC undergo staging neck.This prospective study included 60 from January 1 through June 30, 2006. Patients had undergone previous no...
Abstract Promoter hypermethylation is gaining strength as one of the main mechanisms through which tumor suppressor genes are silenced during progression. Three frequently found methylated in their promoter, concordance with absence expression, RASSF1A , SLIT2 and WIF1. In addition, a previous array‐CGH analysis from our group showed that these deleted genomic regions observed hereditary breast cancer tumors. present work we analyzed methylation status three gene promoters 47 tumors revealed...
// Carolina Alvarez 1, * , Teresa Tapia Elisa Perez-Moreno 1 Patricia Gajardo-Meneses Catalina Ruiz 2 Mabel Rios 3 Claudio Missarelli Mariela Silva Adolfo Cruz 4 Luis Matamala 5 Carvajal-Carmona 6 Mauricio Camus and Pilar Carvallo Department of Cell Molecular Biology, Faculty Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile Centro Cáncer, Medicine, Unidad Patología Mamaria, Hospital Base Valdivia, Barros Luco Trudeau, Regional Antofagasta,...
BACKGROUND: Mechanisms that lead to the reduced expression of BRCA1 in triple-negative breast cancer (TNBC) tumors are not fully understood. A possible cause is overexpression miR-146a and miR-638, which regulate other cancers. OBJECTIVE: To evaluate these m icroRNAs relation TNBC tumors. METHODS: Expression both microRNAs was assessed by real time qPCR using Taqman microRNA assays Results were related protein patient's survival. RESULTS: miR-638 overexpressed 36% 59% tumors, respectively....
Array CGH analysis of breast tumors has contributed to the identification different genomic profiles in these tumors. Loss DNA repair by BRCA1 functional deficiency cancer been proposed as a relevant contribution progression for with no germline mutation. Identifying alterations taking place not expressing will lead us better understanding cellular functions affected this heterogeneous disease. Moreover, specific may contribute potential therapeutic targets and offer more personalized...
Molecular testing contributes to improving the diagnosis of indeterminate thyroid nodules (ITNs). ThyroidPrint® is a ten-gene classifier aimed rule out malignancy in ITN. Post-validation studies are necessary determine real-world clinical benefit patients with A single-center, prospective, noninterventional utility study was performed, analyzing impact physicians' decisions for Demographics, nodule characteristics, benign call rates (BCRs), and surgical outcomes were measured....
Breast cancer (BC) is the most common malignancy in women. We retrieved medical records from >2,000 Chilean BC patients over 1997-2018 period. The objective was to assess changes clinical presentation or prognosis of our throughout these 20 years practice. Although variables did not display significant variations, we observed a progressive increase stage IV this Our data showed that tumour III/IV HER2-enriched subtype tumours were associated with poorer prognosis. In contrast, found...
Although fairly uncommon, loco-regional recurrence in breast cancer (BC) has major consequences for the patient. Several predictors locoregional have been previously reported from large randomized clinical trials mainly Europe & North America; data other geographical areas are somewhat scarce. Here we performed a retrospective review of medical records single academic center Chile, searching tumor recurrence.Median patient follow up was 61 months, 5 year overall survival (OS) rate 94.2% (95%...
Background: Young onset breast cancer (BC) has a worse outcome as compared to in the elderly.However, some studies have shown that BC elderly, despite indolent features, does also cause increase mortality.In an attempt compare clinic-pathological characteristics, subtypes and survival patients with presenting at extremes of age, we performed retrospective study.Materials Methods: Patients were either ≤40 or ≥70 years old.Subtypes defined using immunohistochemistry histological...
Breast cancer (BC) is a heterogeneous disease and cell proliferation markers may help to identify subtypes of clinical interest. We here analyzed the correlation between determined by Ki67 HG in BC patients undergoing preoperative chemotherapy (PCT).We obtained clinical/pathological data from with invasive treated at our institution 1999 until 2012. Expression estrogen receptor (ER), progesterone (PR), epidermal growth factor type 2 (HER2) were immuno-histochemistry (IHC)....
Introduction:Recent reports show that pregnancy-associated breast cancer (PABC) survival is similar to of non-pregnant young patients.We evaluate the characteristics and prognosis PABC patients treated in our centre. Patients methods:We identified with invasive who were between 1999 May 2013 compared their a no cohort age. Results:The prevalence was 1% (n = 17).The median age 35 years (range: 29-42 years).The initial tumour suspected clinically 93% cases.Total mastectomy rates higher women...
Background: Pathological factors, based mainly on immunohistochemistry (IHC) and histological differentiation, are mostly used to differentiate breast cancer (BC) subtypes. Our present aim was describe the characteristics survival of a relapsing BC patient cohort clinico-pathologic subtypes determined for primary tumors. Methods: We clinico- pathological definition grade (HG), estrogen receptor (ER), progesterone (PgR),and epidermal growth factor type 2 (HER2) expression assessed by IHC....
Background: Breast cancer (BC) is the leading cause of death for Chilean women.About 11% cases are triple-negative (TN) BC.These characterised by poor prognosis, higher risk early recurrence and visceral dissemination versus other BC subtypes.Current standard treatment early-stage non-metastatic TNBC patients consists neoadjuvant chemotherapy (NACT) followed surgery radiotherapy.Pathological complete response (pCR) to NACT associated with an increase in survival rates.In general, adjuvant...
Objective: Tumor response to neoadjuvant chemotherapy (NAC) in breast cancer (BC) patients is a predictor for overall survival. The aim of our study was determine relationship between the neutrophil lymphocyte ratio (NLR) prior NAC, BC subtypes and probability pathologic complete (pCR). Materials Methods: Medical records were collected retrospectively from Centro de Cancer at Red Salud UC-Christus. Clinical data included peripheral blood cell counts, subtype diagnosis pathology report...
a pioneer simulation curriculum of suture technique training for medical students introduction: Simulation has demonstrated utility in skills on surgical residents.Objective: Evaluate validity simulated basic students.methods: Study conducted 2013.Medical were selected from the School Medicine Pontificia Universidad Católica de Chile (EMPUC).The program included four theoretical sessions and six practical order to tasks (five total) rubber model: one handed knot-tying, simple suture,...
The white blood cell count is one of the most sensitive markers associated with inflammation. neutrophil/lymphocyte ratio may be an independent factor for breast cancer mortality.To assess predictive value mortality in cancer.Review database a center University hospital. Patients infiltrating treated between 1997 and 2012 were selected. pathology type lymph node involvement obtained from report. expression estrogen, progesterone Human Epidermal Growth Factor Receptor 2 (HER2) was determined...
Inmunohistoquímica convencionalcomo predictor de respuesta y sobrevida en