A5103151291- Cancer Genomics and Diagnostics
- Retinal Diseases and Treatments
- Genomics and Rare Diseases
- Retinal Development and Disorders
- Genetic diversity and population structure
- Genetic factors in colorectal cancer
- Prenatal Screening and Diagnostics
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- FOXO transcription factor regulation
- Morphological variations and asymmetry
- Evolution and Paleontology Studies
- Identification and Quantification in Food
- Genomic variations and chromosomal abnormalities
- Metabolism, Diabetes, and Cancer
- Connexins and lens biology
- Hip and Femur Fractures
- Advanced Breast Cancer Therapies
- Glaucoma and retinal disorders
- Bone fractures and treatments
- Bone health and osteoporosis research
- Cancer Risks and Factors
- Turtle Biology and Conservation
- Genetics, Bioinformatics, and Biomedical Research
- Nutrition, Genetics, and Disease
Pontificia Universidad Católica de Chile
2017-2024
Fundación Universitaria de Ciencias de la Salud
2023
Universidad Nacional de Colombia
2014-2023
Centro de Investigación Biomédica en Red
2017
Hospital Universitario La Paz
2017
Millennium Institute on Immunology and Immunotherapy
2017
// Rafaela Erices 1, 2 , Sofía Cubillos Raúl Aravena 2, 3 Felice Santoro Monica Marquez Renan Orellana 15 Carolina Ramírez Pamela González 4 Patricia Fuenzalida María Loreto Bravo 4, 5 Bárbara Oliva Sumie Kato 1 Ibañez 5, 6, 7 Jorge Brañes Erasmo 8 Catalina Alonso Karen García 7, 9 Clemente Arab 10 Vicente A. Torres 11, 16 Alejandro S. Godoy 12 Jaime Pereira 6 Galdo Bustos 13 Julio Cesar Cardenas 13, 14 Mauricio Cuello Gareth I. Owen Division of Obstetrics and Gynecology, Faculty Medicine,...
Identification of units within species worthy separate management consideration is an important area conservation. Mitochondrial DNA (mtDNA) surveys can potentially contribute to this by identifying phylogenetic and population structure below the level. The American crocodile (Crocodylus acutus) broadly distributed throughout Neotropics. Its numbers have been reduced severely with threatened much its distribution. In Colombia, release individuals from commercial captive populations has...
Background: Breast cancer (BC) is the leading cause of death for Chilean women.About 11% cases are triple-negative (TN) BC.These characterised by poor prognosis, higher risk early recurrence and visceral dissemination versus other BC subtypes.Current standard treatment early-stage non-metastatic TNBC patients consists neoadjuvant chemotherapy (NACT) followed surgery radiotherapy.Pathological complete response (pCR) to NACT associated with an increase in survival rates.In general, adjuvant...
Next-generation sequencing (NGS) is progressively being used in clinical practice. However, several barriers preclude using this technology for precision oncology most Latin American countries. To overcome some of these barriers, we have designed a 25-gene panel that contains predictive biomarkers current and near-future available therapies Chile America. Library preparation was optimized to account low DNA integrity observed formalin-fixed paraffin-embedded tissue. The workflow includes an...
Abstract Advances in understanding the genetic landscape of cancer have paved way for more precise molecular profiling and development efficacious therapeutic options. However, underrepresentation clinical research endeavors has left Latin American population uncharacterized, which may prevent them from reaping benefits these advancements. This study sought to identify drivers actionable mutations solid tumors Chilean patients, enhancing our mutational a with genetically diverse background...
Context Spectacled caiman (Caiman crocodilus) is a species complex with at least eight phylogenetic lineages distributed across Central and South America. However, several populations remain unstudied, which limits clear understanding of the relationship among as well whether all hidden diversity has been unveiled. Aim We analysed molecular variation spectacled inhabiting Colombian Trans-Andean range based on cytochrome oxidase I (COI) B (CytB) mitochondrial markers. Methods performed...
<h3>Background</h3> Osteoporosis is one of the main public health problems, leading to appearance fragility fractures. Within these, there are vertebral fractures, which in their vast majority have an asymptomatic course, why they presented as incidental findings imaging studies. <h3>Objectives</h3> To estimate prevalence insufficiency fractures thoracic vertebrae patients hospitalized for any cause a Hospital Bogotá (Colombia). <h3>Methods</h3> Cross-sectional study sub population Latin...
Abstract The genomic characterization of solid tumors and a rapidly growing repertoire target drugs are revolutionizing cancer treatment. Next-generation sequencing (NGS) panels progressively used in clinical practice for therapy high-income countries. In contrast, limited access to tumor sequencing, among other barriers, precludes precision treatment low- middle-income To build towards the implementation oncology Chile Latin America, we designed 25-gene panel that contains predictive...