A5103176976- Glioma Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Drug Transport and Resistance Mechanisms
- Mechanisms of cancer metastasis
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Histone Deacetylase Inhibitors Research
- Nitric Oxide and Endothelin Effects
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Autophagy in Disease and Therapy
- Cancer therapeutics and mechanisms
- RNA Interference and Gene Delivery
- Colorectal Cancer Treatments and Studies
- Cancer Mechanisms and Therapy
- Brain Metastases and Treatment
- Pancreatic and Hepatic Oncology Research
- Neuroscience and Neuropharmacology Research
- Curcumin's Biomedical Applications
- Genetics, Bioinformatics, and Biomedical Research
- Virus-based gene therapy research
University of Chile
2024
Austral University of Chile
2017-2023
Millennium Institute on Immunology and Immunotherapy
2022-2023
Glioblastoma (GBM) is a neoplasm characterized by an extensive blood vessel network. Hypoxic niches of GBM can induce tumorigenic properties small cell subpopulation called stem-like cells (GSCs) and also increase extracellular adenosine generation which activates the A₃ receptor (A₃AR). Moreover, GSCs potentiates persistent neovascularization in GBM. The aim this study was to determine if A₃AR blockade reduce vasculogenesis mediated differentiation Endothelial Cells (ECs) under hypoxia. We...
Glioblastoma (GBM) is the most common and aggressive type of brain tumor due to its elevated recurrence following treatments. This mainly mediated by a subpopulation cells with stemness traits termed glioblastoma stem-like (GSCs), which are extremely resistant anti-neoplastic drugs. Thus, an advancement in understanding molecular processes underlying GSC occurrence should contribute significantly towards progress reducing aggressiveness. High levels endothelin-converting enzyme-1 (ECE1), key...
Glioblastoma is the brain tumor with worst prognosis. This mainly due to a cell subpopulation an extremely aggressive potential, called glioblastoma stem-like cells (GSCs). These produce high levels of extracellular adenosine, which are increased even more under hypoxic conditions. Under hypoxia, adenosine signaling related HIF-2α expression, enhancing aggressiveness. Adenosine can be degraded using recombinant deaminase (ADA) revert its pathological effects. The aim this study was degrade...
Poor response to current treatments for glioblastoma has been attributed the presence of stem-like cells (GSCs). GSCs are able expel antitumor drugs extracellular medium using multidrug resistance-associated protein 1 (MRP1) transporter. Tacrolimus (FK506) identified as an MRP1 regulator in differentiated (GBM) (non-GSCs); however, effect FK506 on is currently unknown. The objective following research evaluate MRP1-related chemo-resistant phenotype GSCs. For this, U87MG and C6 glioma cell...
Colorectal cancer (CRC) is the second leading cause of deaths globally. While ethnic differences in driver gene mutations have been documented, South American population remains understudied at genomic level, despite facing a rising burden CRC. We analyzed tumors 40 Chilean CRC patients (Chp) using next-generation sequencing and compared them to data from mainly Caucasian cohorts (TCGA MSK-IMPACT). identified 388 96 out 135 genes, with TP53 (45%), KRAS (30%), PIK3CA (22.5%), ATM (20%), POLE...
Glioblastoma (GBM) is the most common and deadly malignant brain tumor, with a median survival of 15 to 17 months for patient. GBM contains cellular subpopulation known as stem-like cells (GSCs) that persist in hypoxic niches are capable infiltrating into healthy tissue. For this reason, GSCs considered one main culprits recurrence. A microenvironment increases extracellular adenosine levels, activating low affinity A2B receptor (A2BAR). Adenosine, through A2BAR, modulating invasiveness....
Glioblastoma is the most common and aggressive primary brain tumor, characterized by its high chemoresistance presence of a cell subpopulation that persists under hypoxic niches, called glioblastoma stem-like cells (GSCs). The GSCs mediated in part adenosine signaling ABC transporters, which extrude drugs outside cell, such as multidrug resistance-associated proteins (MRPs) subfamily. Adenosine promotes MRP1-dependent normoxia. However, adenosine/MRPs-dependent hypoxia has not been studied...
Abstract Advances in understanding the genetic landscape of cancer have paved way for more precise molecular profiling and development efficacious therapeutic options. However, underrepresentation clinical research endeavors has left Latin American population uncharacterized, which may prevent them from reaping benefits these advancements. This study sought to identify drivers actionable mutations solid tumors Chilean patients, enhancing our mutational a with genetically diverse background...
Gallbladder cancer (GBC) is a prevalent and deadly biliary tract carcinoma, often diagnosed at advanced stages with limited treatment options. The 5-year survival rate varies widely from 4 to 60%, mainly due differences in disease stage detection. With only small fraction of patients having resectable tumors high incidence metastasis, GBC are characterized by significant chemoresistance. Identification new therapeutic targets crucial, recent studies have shown that the Endothelin-1 (ET-1)...