A5065360308- Pelvic floor disorders treatments
- Pelvic and Acetabular Injuries
- Anorectal Disease Treatments and Outcomes
- Hernia repair and management
- Pregnancy-related medical research
- Urological Disorders and Treatments
- Ureteral procedures and complications
- Ovarian function and disorders
- Osteoarthritis Treatment and Mechanisms
- Tissue Engineering and Regenerative Medicine
- Assisted Reproductive Technology and Twin Pregnancy
- Urinary Bladder and Prostate Research
- Reproductive Biology and Fertility
- Diverticular Disease and Complications
- Reproductive Health and Technologies
- Cardiac Valve Diseases and Treatments
- Bladder and Urothelial Cancer Treatments
- Urinary Tract Infections Management
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Function and Risk Factors
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Advanced MRI Techniques and Applications
- Sleep and related disorders
- Microbial metabolism and enzyme function
Northwestern University
2022-2025
Northwestern Medicine
2022
Georgetown University
2018-2021
Cleveland Clinic
2012-2019
Pontificia Universidad Católica de Chile
2018
Complejo Asistencial Sótero del Río
2018
Cleveland Clinic Lerner College of Medicine
2014-2017
Cleveland State University
2014-2017
Louis Stokes Cleveland VA Medical Center
2016
In-Q-Tel
2016
Tissue engineered cardiac grafts are a promising therapeutic mode for ventricular wall reconstruction. Recently, it has been found that acellular tissue scaffolds provide natural ultrastructural, mechanical, and compositional cues recellularization remodeling. We thus assess the potential of decellularized porcine myocardium as scaffold thick patch engineering. Myocardial sections with 2-mm thickness were using 0.1% sodium dodecyl sulfate then reseeded differentiated bone marrow mononuclear...
Pelvic organ prolapse is a vaginal protrusion of female pelvic organs. It has high prevalence worldwide and represents great burden to the economy. The pathophysiology multifactorial includes genetic predisposition, aberrant connective tissue, obesity, advancing age, delivery other risk factors. Owing long course prior patients becoming symptomatic ethical questions surrounding human studies, animal models are necessary useful. These can mimic different characteristics - histological,...
A scaffoldless or self-assembly approach to cartilage tissue engineering has been used produce hyaline from bone marrow-derived mesenchymal stem cells (bMSCs), but the mechanical properties of such engineered and effects transforming growth factor (TGF) isoform have not fully explored. This study employs a cell culture insert model tissue-engineered using bMSCs. Neonatal pig bMSCs were isolated by plastic adherence expanded in monolayer before being seeded into porous transwell inserts...
Importance Vaginal pessaries are an effective nonsurgical treatment for pelvic organ prolapse (POP) when properly fitted. However, pessary fitting and use often unsuccessful or imperfect. Objective The objective of this study was to assess the feasibility using patient-specific fabricated from three-dimensional (3D)-printed molds improve POP symptoms increase overall satisfaction in patients standard vaginal pessaries. Study Design Patients undergoing with were enrolled pilot prospective...
Objective To evaluate whether the percentage of time spent supine during sleep in third trimester pregnancy could be reduced using a positional therapy device (PrenaBelt) compared with sham device. Design A double-blind, randomised, sham-controlled, cross-over pilot trial. Setting Conducted between March 2016 and January 2017, at single, tertiary-level centre Canada. Participants 23 participants entered study. 20 completed were low-risk, singleton, third-trimester pregnant women aged 18...
Lysyl oxidase-like 1 knockout (Loxl1) mice demonstrate deficient elastin homeostasis associated with pelvic organ prolapse (POP). To further investigate the pathophysiology of POP in these animals, a genetically matched homozygous positive or wild-type strain is needed. This study sought to create and validate Loxl1 strains.
To test whether a customized positional therapy device, PrenaBelt, would reduce time spent sleeping supine and evaluate any change in maternal or fetal parameters, group of healthy pregnant women the third trimester pregnancy.
Objective: To evaluate the association between embryo transfer technique and pregnancy outcome.Design: Prospective observational with retrospective cohort Subjects: Physicians performing patients undergoing transfers 2015-2020.Intervention/Exposures(s): Fourteen physicians performed 25 mock on simulator completed a questionnaire assessing preferred techniques.Quantitative performance metrics were measured.Individual physician success rates retrospectively collected from all fresh...
The aim of this study was to compare differences in expressions and relationships between key genes involved extracellular matrix metabolism tissue cellularity women with without pelvic organ prolapse (POP).A total 80 biopsies (anterior cuff, posterior and/or leading edge) were obtained from 30 women: n = 10 premenopausal POP (controls), POP, postmenopausal POP. Quantitative reverse-transcriptase polymerase chain reaction used assess gene expression bone morphogenetic protein 1 (BMP1),...
Under disease or injury conditions in the central nervous system (CNS), activated microglia release cytokines and chemokines to modulate microenvironment influence tissue remodeling.
Undifferentiated connective tissue that arises during embryonic development and some healing processes contains pluripotent mesenchymal stem cells. It is becoming increasingly evident the mechanical environment an important differentiation factor for these In our laboratory, we have focused on potential signals to induce chondrogenic of Using C3H10T1/2 cells as a model, investigated influence hydrostatic pressure, equibiaxial contraction, centrifugal pressure chondroinduction. Cells...
Pelvic organ prolapse (POP) in lysyl oxidase like-1 knockout (Loxl1 KO) mice occurs primarily parous and is rare nulliparous mice. We determined the effect of Loxl1 deficiency on postpartum regulation connective tissue metabolism genes degradative enzyme activity vagina at 20 days gestation or 4 h, 48 7 days, 15 25 weeks, 12 weeks postpartum. Nulliparous KO wildtype (WT) aged 11, 18, 23 were controls. Gene expression assessed using real-time quantitative reverse transcription PCR fluorescein...
Objectives The aim of this study was to determine the effect pregnancy and delivery mode on cytokine expression in pelvic organs serum lysyl oxidase like-1 knockout ( LOXL1 KO) mice, which develop organ prolapse after delivery. Methods Bladder, urethra, vagina, rectum, blood were harvested from female KO mice during pregnancy, vaginal or cesarean delivery, sham unmanipulated controls. Pelvic also pregnant vaginally delivered wild-type (WT) virgin WT Specimens assessed using quantitative...
To evaluate the effect, on birth weight and centile, of use PrenaBelt, a maternal positional therapy device, during sleep in home setting throughout third trimester pregnancy.A double-blind, sham-controlled, randomised clinical trial.Conducted from September 2015 to May 2016, at single, tertiary-level centre Accra, Ghana.Two-hundred participants entered study. One-hundred-eighty-one completed Participants were women, 18 35 years age, with low-risk, singleton, pregnancies their...
The effect of Short-term Plyometric Training Program on Sprint, Strength, Power and Agility Performance in non-athletic Men Aalizadeh, Ali Shirkhani, Sedighe Foroughi Borazjani, Men Abstract Plyometric training to increase physical ability leads muscles power. aim the study was assess effects short term plyometric program sprint, strength, power agility performance men. In this research, 40 men (year 18-23) participated. participants were chosen randomly they participated four tests...
The mechanical properties of engineered cartilage are strongly dependent on collagen content, but the to glycosaminoglycan ratio in is often much lower than that native tissue. Therefore culture medium supplements