A5108020986- Advanced biosensing and bioanalysis techniques
- Electrochemical Analysis and Applications
- DNA and Nucleic Acid Chemistry
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- bioluminescence and chemiluminescence research
- Trace Elements in Health
- Analytical chemistry methods development
- Cancer, Stress, Anesthesia, and Immune Response
- Mycotoxins in Agriculture and Food
- Computational Drug Discovery Methods
- Insect and Pesticide Research
- Cholinesterase and Neurodegenerative Diseases
- Microfluidic and Capillary Electrophoresis Applications
- Nicotinic Acetylcholine Receptors Study
- Biochemical Analysis and Sensing Techniques
- Chromium effects and bioremediation
- Molecular Sensors and Ion Detection
- Metal complexes synthesis and properties
Universidade Federal Rural de Pernambuco
2006-2017
University of Coimbra
2007-2013
Universidade Federal da Paraíba
2006
In situ DNA oxidative damage by electrochemically generated hydroxyl free radicals has been directly demonstrated on a boron-doped diamond electrode. The DNA-electrochemical biosensor incorporates immobilized double-stranded (dsDNA) as molecular recognition element the electrode surface, and measures in specific binding processes with dsDNA, it is complementary tool for study of bimolecular interaction mechanisms compounds to enabling screening evaluation effect caused health hazardous...
Abstract The electrochemical behaviour of temozolomide on a glassy carbon electrode has been investigated. reduction is an irreversible process, pH dependent, and the mechanism involves addition one electron proton to C5 form anion radical, causing breakdown tetrazinone ring. oxidation irreversible, adsorption‐controlled dependent up value close p K occurs in two consecutive charge transfer reactions, with formation hydroxylated product. electroanalytical determination TMZ led detection limit 1.1 µM.
Abstract Thalidomide is an oral drug marketed in the 1950s as a sedative and anti‐emetic during pregnancy that was removed from market when its teratogenic side effects appeared new born children due to inadequate tests assess drug's safety. Recent studies evaluating use of thalidomide cancer HIV diseases have sparked renewed interest. The electrochemical behavior on glassy carbon electrode has been investigated using cyclic, differential square‐wave voltammetry aqueous media at different...
Abstract Metolazone is a diuretic agent used in patients with edematous states and/or hypertension. The electrochemical behavior of metolazone on glassy carbon electrode was investigated using cyclic, differential pulse, and square‐wave voltammetry at different pHs. pH dependent oxidation occurs two consecutive steps diffusion‐controlled mechanism involves the formation main product. first process reversible, electrons protons corresponding to nitrogen sulfonamide moiety. second...
An amine-functionalized porous sol–gel silica film was shown to be an effective platform immobilize small anionic redox mediators of high solubility on solid electrodes by electrostatic interaction. The highly soluble mediator hexacyanoferrate used as a model. grown and firmly anchored gold electrode surface via thiol groups self-assembled monolayer (3-mercaptopropyl)trimethoxysilane. Film growth thickness were controlled electrochemical modulation pH at the electrode/solution interface in...