A5101906936- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Urological Disorders and Treatments
- Cyclopropane Reaction Mechanisms
- Bladder and Urothelial Cancer Treatments
- Crystallization and Solubility Studies
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Analysis
- Diverse Musicological Studies
- Synthesis and Catalytic Reactions
- Synthetic Organic Chemistry Methods
- X-ray Diffraction in Crystallography
- Electrocatalysts for Energy Conversion
- Ukrainian Legal and Forensic Studies
- Kidney Stones and Urolithiasis Treatments
- Nonmelanoma Skin Cancer Studies
- Prenatal Substance Exposure Effects
- Urinary and Genital Oncology Studies
- Traditional and Medicinal Uses of Annonaceae
- CO2 Reduction Techniques and Catalysts
- Global Cancer Incidence and Screening
- Polyomavirus and related diseases
- Ureteral procedures and complications
- Cardiac Fibrosis and Remodeling
University of New Mexico
2023
California Institute of Technology
2021-2022
Scripps (United States)
2021
Scripps Institution of Oceanography
2021
Scripps Research Institute
2017-2020
Richland College
2015
Pacific Northwest National Laboratory
2015
Northeastern University
2015
Clemson University
2003
Rogers (United States)
2000
We and others recently isolated a human p53 homologue ( p40 / p51 p63 p73L ) localized the gene to distal long arm of chromosome 3. Here we sought examine role , two variants lacking N-terminal transactivation domain, in cancer. Fluorescent situ hybridization (FISH) analysis revealed frequent amplification this locus primary squamous cell carcinoma lung head neck cancer lines. (We named AIS for mplified i n s quamous carcinoma.) Furthermore, was accompanied by RNA protein overexpression...
One of the most oft-employed methods for C–C bond formation involving coupling vinyl-halides with aldehydes catalyzed by Ni and Cr (Nozaki–Hiyama–Kishi, NHK) has been rendered more practical using an electroreductive manifold. Although early studies pointed to feasibility such a process, those precedents were never applied others due cumbersome setups limited scope. Here we show that carefully optimized procedure can enable sustainable approach NHK, even in asymmetric fashion on highly...
A catalytic γ-selective <italic>syn</italic>-hydroarylation of alkenyl carbonyl compounds using arylboronic acids has been developed a substrate directivity approach with palladium(<sc>ii</sc>) catalyst.
Kinetic and mechanistic studies of the desymmetrization benzhydrylamine using Pd/monoprotected amino acid ligands (Pd/MPAA) via C-H functionalization with molecular iodine provide insight into rate-determining step oxidation state Pd in step. Enantiomeric excess is strikingly insensitive to temperature from ambient up over 70 °C, reaction rate electronic characteristics ligand's benzoyl protecting group. The highly robust no evidence catalyst deactivation. Intriguingly, bond breaking does...
No AccessJournal of Urology1 Aug 1990Management Pregnancy after Augmentation Cystoplasty David E. Hill and Stephen A. Kramer HillDavid More articles by this author KramerStephen View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39488-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We contacted 256 members the Society for Pediatric Urology determine their experience with patients who had undergone...
Mechanistic investigations uncover a novel role for 2-pyridone ligands and interrogate the origin of enantioselectivity in (+)-norbornene-mediated Pd-catalyzed meta-C(aryl)–H functionalization diarylmethylamines. Observations from kinetic analysis concert with situ 19F NMR monitoring allow us to propose that pyridone ligand plays enhancing rate- enantio-determining insertion an arylpalladium species into chiral norbornene derivative. The unprecedented features asymmetric 1,2 migratory...
No AccessJournal of UrologyStones1 Aug 1990Ureteroscopy in Children David E. Hill, Joseph W. Segura, Patterson, and Stephen A. Kramer HillDavid Hill , SeguraJoseph Segura PattersonDavid Patterson KramerStephen View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)39496-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The development ureteroscopy has led a dramatic change the management ureteral stones as well...
The potential role of dimeric catalyst species on or off the catalytic cycle is considered for a case Pd-catalyzed C–H functionalization, leading to development general experimental protocol that uses reaction itself report presence and in asymmetric reactions.
We present a systematic study of the effect number methyl (Me) and cyclohexyl (Cy) functional groups in monodentate phosphine ligands on solution-phase synthesis ligated sub-nanometer gold clusters their gas-phase fragmentation pathways. Small mixed ligand cationic were synthesized using reactions between pre-formed triphenylphosphine (PPh3) Me- Cy-substituted solution characterized electrospray ionization mass spectrometry (ESI-MS) collision-induced dissociation (CID) experiments. Under...
A new tool for probing enantioselective reaction mechanisms is introduced. Monitoring the temporal change in product enantiomeric excess after addition of opposite enantiomer ligand during provides a means dynamic exchange C-H iodination catalyzed by Pd with monoprotected amino acid ligands (MPAAs). This work has general potential to provide insights about dynamics catalyst and molecularity exchange.
Abstract Prenatal alcohol exposure (PAE), the leading known cause of childhood developmental disability, has long‐lasting effects extending throughout lifespan. It is well documented that children prenatally exposed to have difficulties inhibiting behavior and sustaining attention. Thus, Sustained Attention Response Task (SART), a Go/No‐go paradigm, especially suited assess behavioral neural functioning characteristics with PAE. In this study, we utilized neuropsychological assessment,...
Chiral monoprotected aminoethyl amine (MPAAM) ligands were recently reported to facilitate enantioselective Pd-catalyzed arylation of strong cyclopropane C(sp3)–H bonds. Herein, we describe detailed experimental and theoretical investigations into the influence MPAAM ligands, L1 L2, as well a thioether (MPAThio) ligand, L3, on reaction kinetics, product enantioselectivity, turnover number. We show an unusual negative nonlinear effect in ligand enantiopurity rate ee that has not been shown...
No AccessJournal of Urology1 May 1988Treatment Complications Cyclophosphamide Cystitis Gerald R. Jerkins, H. Norman Noe, and David Hill JerkinsGerald Jerkins More articles by this author , NoeH. Noe HillDavid View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)42718-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Since 1976, 23 patients with cyclophosphamide-induced cystitis were treated. These presented a...
The study and application of transition metal hydrides (TMH) has been an active area chemical research since the early 1960’s. use TMHs broadly bifurcated into fields focused on energy storage through reduction protons to generate hydrogen in organic synthesis for functionalization unsaturated C–C, C–O, C–N bonds. In former instance, electrochemical means driving such reactivity commonplace 1950’s. contrast, stoichiometric exogenous metal-based reductants harness power synthetic chemistry...
Significance The manipulation of proteins in a site-selective manner underpins much modern protein chemistry. A careful evaluation selenomethionine benzylation led to the identification highly efficient bromobenzyl linker for bioconjugation. This selenonium-forming ligation reaction can efficiently link other complex molecules such as synthetic peptides, polymers, or reactive handles. selenonium product is sufficiently stable at physiological pH, yet cleaved by glutathione intracellular...
Journal Article HR-TEM and EELS Studies of Soluble Aminopolymer-Functionalized Single-Walled Carbon Nanotubes Get access Y Lin, Lin Department Chemistry Center for Advanced Engineering Fibers Films, Howard L. Hunter Laboratory, Clemson University, Clemson, SC 29634-0973 Search other works by this author on: Oxford Academic Google Scholar D E Hill, Hill J Bentley, Bentley Metals Ceramics Division, Oak Ridge National Ridge, TN 37831-6064 L F Allard, Allard Y-P Sun Microscopy Microanalysis,...