A5012971683- CAR-T cell therapy research
- Drug Transport and Resistance Mechanisms
- Epilepsy research and treatment
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Barrier Structure and Function Studies
- Autophagy in Disease and Therapy
- Virus-based gene therapy research
- Integrated Circuits and Semiconductor Failure Analysis
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- Diverse Approaches in Healthcare and Education Studies
- Anesthesia and Sedative Agents
- Pancreatic function and diabetes
- Neurological Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Microfluidic and Capillary Electrophoresis Applications
- Fatty Acid Research and Health
- Nanofabrication and Lithography Techniques
- Electronic Packaging and Soldering Technologies
- Dysphagia Assessment and Management
- Pain Mechanisms and Treatments
Texas Tech University Health Sciences Center
2020-2025
Texas Tech University
2020-2025
King Saud University
2023
Chapman University
2023
University of Minnesota
2018
ULK1 (unc51-like autophagy activating kinase 1) is a serine/threonine that plays key role in regulating macroautophagy/autophagy induction response to amino acid starvation. Despite the recent progress understanding functions, molecular mechanism by which regulates of remains elusive. In this study, we determined phosphorylates Ser30 BECN1 (Beclin association with ATG14 (autophagy-related 14) but not UVRAG (UV radiation resistance associated). The phosphorylation was induced deprivation...
To investigate whether bihemispheric anodal transcranial direct current stimulation (tDCS) with conventional dysphagia therapy could improve swallowing function in chronic stroke patients dysphagia.Randomized controlled trial.Twenty-six for at least 6 months post-stroke were randomly assigned into: (i) tDCS group; or (ii) sham group.All underwent 10 sessions simultaneous 2 weeks. Both electrodes attached bilaterally to the pharyngeal motor cortices, and cathodal both supraorbital regions....
The purpose of this study was to investigate the effects volatile anesthetic agents isoflurane and sevoflurane, at clinically relevant concentrations, on fluidity lipid membranes permeability blood-brain barrier (BBB). We analyzed in vitro or ketamine using erythrocyte ghosts (sodium fluorescein permeability), monolayers brain microvascular endothelial cells ([<sup>13</sup>C]sucrose liposomes (fluorescence anisotropy). Additionally, we determined 30-minute exposure mice tight junction...
The membrane fluidity increases induced by popular anesthetic agents (propofol, isoflurane, sevoflurane, and ketamine/xylazine) were measured at the clinical supra-clinical concentrations in red blood cell (RBC) as well four model membranes. Membrane changes monitored using excimer/monomer (E/M) ratio of dipyrene-PC fluorescence anisotropies DPH-PC TMA-DPH. Propofol, sevoflurane isoflurane increased instantaneously. largest increase occurs membranes made saturated lipids. RBCs labeled with...
Abstract Background Understanding the pathophysiology of blood brain–barrier (BBB) plays a critical role in diagnosis and treatment disease conditions. Applying sensitive specific LC–MS/MS technique for measurement BBB integrity with high precision, we have recently introduced non-radioactive [ 13 C 12 ]sucrose as superior marker substance. Comparison permeability markers different molecular weight, but otherwise similar physicochemical properties, can provide insights into uptake mechanism...
Metformin's potential in treating ischemic stroke and neurodegenerative conditions is of growing interest. Yet, the absence established systemic brain pharmacokinetic (PK) parameters at relevant preclinical doses presents a significant knowledge gap. This study highlights these PK importance using pharmacologically to pharmacodynamics related diseases. A liquid chromatography with tandem mass spectrometry method measure metformin levels plasma, brain, cerebrospinal fluid was developed...
Introduction: Despite the prevalence of perception that electronic cigarettes (e-cig) are a safer alternative to tobacco smoke, growing concern about their potential toxic impact warrants adequate investigation focusing on special populations like maternal and pediatric groups. This study evaluated consequences e-cig use neonatal neuroinflammation, oxidative stress, mitochondrial function in primary cultured neurons postnatal day (PD) 7 90 brain. Methodology: Pregnant CD1 mice were exposed...
We have recently shown that the volatile anesthetics isoflurane and sevoflurane acutely enhance brain uptake of hydrophilic markers sucrose mannitol about two-fold from an awake condition, while combined injection anesthetic agents ketamine xylazine has no effect. The present study investigated two small-molecule drugs with potential neurotoxicity, antibiotic ceftazidime gentamicin. Transport studies using in vitro blood–brain barrier (BBB) model, a monolayer induced pluripotent stem...
Epilepsy is a neurological disease that affects 1-3% of the population. People with epilepsy (PWE) have poor physical and psychological health lower quality life (QOL) than people without epilepsy. Moreover, PWE has more comorbid conditions (obesity, depression) general populations. Physical activity (PA) been reported to various positive effects in PWE. Meanwhile, medication adherence one main precipitating factors for seizure triggers. This study assessed impact PA on frequency QOL at...
Milnacipran is a dual serotonin and norepinephrine reuptake inhibitor, clinically used for the treatment of major depression or fibromyalgia. Currently, there are no studies reporting pharmacokinetics (PK) milnacipran after intraperitoneal (IP) injection, despite this being primary administration route in numerous experimental using drug. Therefore, present study was designed to investigate PK profile IP-administered mice compare it intravenous (IV) route. First liquid chromatography–mass...
The vascular system plays a critical role in human physiology and diseases. It is complex subject to study using vitro models due its dynamic three-dimensional microenvironment. Microfluidic technology has recently become popular various biological fields for advantages mimicking microenvironments an extent not achievable by more conventional platforms. technologies can reproduce different system-related structures functions that be utilized drug development diseases studies. Herein, we...
<b>Abstract ID 92047</b> <b>Poster Board 031</b> <b>Background:</b> We have recently established the highly specific and sensitive, stable isotope-labeled permeability marker [<sup>13</sup>C] Sucrose for measuring integrity of blood-brain barrier (BBB), used it to demonstrate an acute 2-fold increase in mice under volatile anesthetics, like isoflurane sevoflurane [1]. Enhanced lipid membrane fluidity is likely responsible mechanism, which results enhanced transcellular [2]. Similarly, a...
Advanced flip chip packaging technology supports the next generation of products with increased die complexities. The increase in complexity and functionality has been driving need to investigate fine-pitch interconnection 3D integration. Recently, Package on (PoP) emerged as preferred integration logic processors memory devices for mobile handsets portable applications. current PoP solution consists top package stacked function bottom package. Various challenges also be met support volume...
Despite favorable results of CAR T-cell therapy for relapsed/refractory large B-cell lymphoma (R/R LBCL), several challenges remain, including incomplete response, immune-mediated toxicity, and antigen-loss relapse. We delineated the relative clinical benefit novel approaches compared to currently approved therapies. In absence head-to-head comparisons randomized controlled trials, we performed Matching Adjusted Indirect Comparisons quantify efficacy safety experimental CARs against...
Abstract Bovine colostrum is composed of a variety biologically active compounds including microRNAs (miRNA), which are found within extracellular vesicles (EVs). Newborn calves agammaglobulinemic. Hence, the ability bovine neonate to fight off pathogens therefore almost entirely dependent upon ingestion. Extracellular vesicle-derived miRNAs may have crucial role in regulation immune response. Thus, we aimed characterize EVs morphology from using stimulated emission depletion (STED) super...
<b>Abstract ID 18127</b> <b>Poster Board 125</b> The Blood-Brain Barrier (BBB) protects the human brain by restricting access of foreign substances to brain, including even beneficial therapeutic agents with extremely low permeability. Receptor-mediated transcytosis (RMT) is a pathway transport macromolecules such as antibodies and peptides across BBB., which has been widely studied drug delivery strategy overcome BBB. We utilized novel T-cell receptor mimic antibody (TCRm) target...