A5101797568- Microscopic Colitis
- Inflammatory Bowel Disease
- Probiotics and Fermented Foods
- Metabolism, Diabetes, and Cancer
- Immunodeficiency and Autoimmune Disorders
- Dermatology and Skin Diseases
- Protein Kinase Regulation and GTPase Signaling
- Infant Health and Development
- Airway Management and Intubation Techniques
- Food Allergy and Anaphylaxis Research
- Pancreatic function and diabetes
- Helicobacter pylori-related gastroenterology studies
- Genetics and Neurodevelopmental Disorders
- Neonatal Respiratory Health Research
- Genetic Syndromes and Imprinting
- Adipose Tissue and Metabolism
- Glycogen Storage Diseases and Myoclonus
- Immune Response and Inflammation
- Vitamin C and Antioxidants Research
- Mitochondrial Function and Pathology
- Medicinal plant effects and applications
- Cardiac electrophysiology and arrhythmias
- Semiconductor Lasers and Optical Devices
- Bioactive Compounds and Antitumor Agents
- Chronic Kidney Disease and Diabetes
Samsung (South Korea)
2009-2025
Samsung Medical Center
2001-2020
Sungkyunkwan University
2001-2020
Dongguk University
2015-2016
Ansan University
2011-2013
Korea University
2006-2013
Seoul National University
2009-2011
National Institute of Ecology
2011
Ulsan College
2002-2007
University of Ulsan
2002-2007
Controversy exists regarding the preventive effect of probiotics on development eczema or atopic dermatitis. We investigated whether supplementation prevents in infants at high risk. In a randomized, double-blind, placebo-controlled trial, 112 pregnant women with family history allergic diseases received once-daily supplement, either mixture Bifidobacterium bifidum BGN4, B. lactis AD011, and Lactobacillus acidophilus AD031, placebo, starting 4-8 wks before delivery continuing until 6 months...
The relatively high cost and patent expiry of infliximab, an anti-tumor necrosis factor monoclonal antibody used in inflammatory bowel disease (IBD), has led to the development biosimilar versions reference product (RP). This study investigated long-term efficacy, safety, pharmacokinetics, immunogenicity CT-P13 after switching from infliximab RP pediatric-onset IBD patients.In this prospective observational study, patients with receiving maintenance were followed for 1 year continuing (RP...
Mucosal healing is an important treatment goal in Crohn's disease. We investigated the association between serum infliximab trough levels and mucosal healing, cut-off required for paediatric patients. In this multicentre, retrospective, cross-sectional study, medical records electronic data of patients with luminal disease, who had received ≥1 year, were examined. Ileocolonoscopy was performed on same day as infusion, samples collected immediately before infusion. defined a Simple Endoscopic...
Background and AimsWe aimed to investigate the outcome in paediatric-onset Crohn's disease patients who had discontinued infliximab after maintaining clinical remission with combined immunosuppression, determine factors associated relapse.
In adipocytes, insulin stimulates glucose transport primarily by promoting the translocation of GLUT4 to plasma membrane. Requirements for Ca2+/ calmodulin during insulin-stimulated have been demonstrated; however, mechanism action Ca2+ in this process is unknown. Recently, myosin II, whose function non-muscle cells regulated phosphorylation its regulatory light chain Ca2+/calmodulin-dependent kinase (MLCK), was implicated translocation. The present studies 3T3- F442A adipocytes demonstrate...
Abstract Background: Helicobacter pylori infection is known to be a cause of iron deficiency anemia (IDA) that unresponsive supplements. H. bind specific receptor by iron‐repressible outer membrane proteins (IROMPs) under conditions restricted iron. Materials and Methods: We compared the expression IROMPs from strains both iron‐restricted iron‐supplemented determine difference between with without IDA. One standard strain, two clinical strains, three IDA were cultured; then extracted...
In secretory cells, osmotic swelling of granules is proposed to be an intermediate step in exocytic fusion the with plasma membrane. For granule, a H + gradient generated by vacuolar-type -ATPase (V-ATPase) may driving force for accumulation K via its exchange , concurrent Cl - and H2O. Here, we investigated whether similar chemiosmotic mechanism involved insulin-stimulated recruitment GLUT4 membrane 3T3-F442A adipocytes. Incubating cells hypo-osmotic medium significantly increased 2-deoxy...
Adiponectin, an adipose tissue-derived hormone, has been negatively related to obstructive sleep apnea syndrome. Besides apnea, children with Prader-Willi syndrome (PWS) may have excessive daytime sleepiness and rapid eye movement (REM) abnormality. The aim of this study is determine whether changes in structures are plasma adiponectin levels PWS. Correlations between level variables were analyzed 28 PWS 18 controls. Overnight polysomnography was performed. fasting higher the than controls...
Background: Limited data exist regarding mucosal healing (MH) and therapeutic drug monitoring (TDM) in pediatric Crohn's disease (CD) patients treated with adalimumab (ADL).We aimed to investigate the associations between ADL trough levels (TLs) MH, TLs histologic remission (HR) at 16 weeks from treatment CD patients.Methods: This was a prospective study on moderate-to-severe luminal receiving ADL.Ileocolonoscopies biopsies, as well clinical activity assessments, laboratory examinations,...
The role of the Ferric Uptake Regulator (FUR) in acid resistance Helicobacter pylori (H. pylori) has been thought to be independent urease. However, we demonstrated this study that Fur influences urease activity.A fur knockout mutant H. was constructed by replacing gene with a kanamycin resistant marker gene. wild-type and were compared for survival. integrity inner membrane bacteria evaluated confocal microscopy using membrane-permeant -impermeant fluorescent DNA probes. Urease activity...
Background/AimsFGF21 (fibroblast growth factor 21) is a novel metabolic regulator that has beneficial effects on glucose homeostasis and insulin sensitivity.In human obesity, serum FGF21 level was increased.The aims of this study were comparing fasting levels in Prader-Willi syndrome (PWS) obese control children finding correlations these with sensitivity obesity-related parameters.