A5039839844- Cardiac electrophysiology and arrhythmias
- Birth, Development, and Health
- Cardiac Arrhythmias and Treatments
- Pharmacogenetics and Drug Metabolism
- ECG Monitoring and Analysis
- Atrial Fibrillation Management and Outcomes
- Neonatal Respiratory Health Research
- Cardiac pacing and defibrillation studies
- Electrolyte and hormonal disorders
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Heart Rate Variability and Autonomic Control
- Ion channel regulation and function
- Ion Transport and Channel Regulation
- Venous Thromboembolism Diagnosis and Management
- Hormonal Regulation and Hypertension
- Cancer-related Molecular Pathways
- Diabetes Treatment and Management
- Receptor Mechanisms and Signaling
- Non-Invasive Vital Sign Monitoring
- Diet and metabolism studies
- Congenital heart defects research
- T-cell and Retrovirus Studies
- Eicosanoids and Hypertension Pharmacology
- Diet, Metabolism, and Disease
St. Marianna University School of Medicine
2014-2025
Tosoh (Japan)
2024
The University of Kitakyushu
2024
Kinki Central Hospital
1998
May Institute
1998
Human T-lymphotropic virus type 1 (HTLV-1) causes the debilitating neuroinflammatory disease HTLV-1–associated myelopathy–tropical spastic paraparesis (HAM–TSP) as well adult T-cell leukemia–lymphoma (ATLL). In patients with HAM–TSP, HTLV-1 infects mainly CCR4+ T cells and induces functional changes, ultimately causing chronic spinal cord inflammation. We evaluated mogamulizumab, a humanized anti-CCR4 monoclonal antibody that targets infected cells, in HAM–TSP.
Highlights•Intravenous infusion of ASCs promoted the functional recovery in SCI rats.•ASC group showed reduced area spinal cord cavitation.•CINC-1 a transient, but substantial increase tissue and blood ASC group.•CINC-1 improved locomotor function similarly to ASCs.AbstractBackground aimsAdipose has therapeutic potential for injury (SCI) because it contains multipotent cells known as adipose-derived stem/stromal (ASCs). In this study, we attempted intravenous transplantation rats with...
The EXPAND study examined the real-world efficacy and safety of rivaroxaban for prevention stroke systemic embolism (SE) in Japanese patients with non-valvular atrial fibrillation (NVAF).This multicenter, prospective, non-interventional, observational, cohort was conducted at 684 medical centers Japan. A total 7141 NVAF ≥20 years age (mean, 71.6 ± 9.4 years) who were being or about to be treated (10 mg/day, 43.5%; 15 56.5%) followed an average 897.1 (±206.8) days a high follow-up rate...
BackgroundElectrical storm (E-Storm), defined as multiple episodes of ventricular arrhythmias within a short period time, is an important clinical problem in patients with implantable cardiac defibrillator (ICD) including resynchronization therapy devices capable defibrillation. The detailed aspects E-Storm large populations especially for non-ischemic dilated cardiomyopathy (DCM), however, remain unclear.ObjectiveThis study was performed to elucidate the E-Storm, such its predictors and...
Corticosteroids are most commonly used to treat HTLV-1-associated myelopathy (HAM); however, their clinical efficacy has not been tested in randomized trials. This controlled trial included 8 and 30 HAM patients with rapidly slowly progressing walking disabilities, respectively. Rapid progressors were assigned (1:1) receive or a 3-day course of intravenous methylprednisolone addition oral prednisolone therapy. Meanwhile, slow placebo. The primary outcomes composite ≥1-grade improvement the...
Hypercholesterolemia and diabetes mellitus are known to be accompanied by reproductive dysfunction. In this study, we investigated the effects of hypercholesterolemia, hyperglycemia, these conditions combined, on testosterone (T) testicular luteinizing hormone/human chorionic gonadotropin (LH/hCG) binding. Sprague-Dawley rats (8 weeks old) were divided into four groups: Group 1 was control, group 2 fed standard chow containing 2% cholesterol (C-diet), 3 administered streptozotocin (STZ, 65...
The autonomic properties in 27 patients with the electrocardiographic morphology of Brugada syndrome were investigated using 24-h Holter monitoring: 10 had a history ventricular fibrillation (VF; Br-VF group) and 17 did not (Br-N group); there 26 healthy subjects enrolled this study. All underwent normal data monitoring power spectral analysis. Few extrasystoles observed either group, mean heart rate (HR), maximum HR, total beats over 24 h obtained. these measurements significantly lower...
Vasoactive intestinal peptide ( VIP ) is a modulator of inflammatory responses. receptors are expressed in several tumor types, such as colorectal carcinoma. The study described herein was conducted to confirm the presence and its VPAC 1 2) surgically resected hepatocellular carcinoma HCC tissues cell line Huh7. mechanism responsible for apoptosis cells then examined because treatment (10 −10 M) significantly suppressed proliferation Huh7 cells. In examining apoptosis‐related proteins, we...
Irinotecan, a DNA topoisomerase I inhibitor, is widely used in cancer chemotherapy. However, little known of the mechanisms its antitumor effects and development drug resistance human hepatocellular carcinoma (HCC). In this study, we investigated short-term culture with SN-38, active metabolite irinotecan, on apoptosis Huh7 cells. The cells were cultured SN-38 for 24, 72, 120 h, was determined using terminal dUTP nick-end labeling (TUNEL) assay. expressions p53, apoptosis-related proteins,...
Adipose tissue contains multipotent cells known as adipose-derived stem/stromal (ASCs), which have therapeutic potential for various diseases. Although the demand adipose research use remains high, no bank exists. In this study, we attempted to isolate ASCs from cryopreserved with aim of developing a banking system. were isolated fresh and rats compared proliferation (doubling time), differentiation capability (adipocytes), cytokine (hepatocyte growth factor vascular endothelial factor)...
Previous study has demonstrated the increase of several cardiac function-related proteins, including creatine kinase (CK) as an important enzyme in process ATP synthesis fetal heart rats administered glucocorticoid (GC) antenatally. In present effect antenatal GC administration on CK expression and neonatal hearts was demonstrated.Dexamethasone to pregnant days 19 20 gestation. The mRNA levels isoforms, CK-M Mi-CK, 21-day-old 1-day-old were significantly increased after administration....
Whether the effect of a low-protein diet on progression to end-stage renal disease (ESRD) and mortality risk differs between young elderly adults with chronic kidney (CKD) is unclear. We conducted retrospective CKD cohort study investigate association protein intake or outcomes whether age affects this association. The comprised 352 patients stage G3-5 who had been followed up for median 4.2 years, undergone educational hospitalization, whom baseline was estimated from 24-h urine samples....
Background:Little is known regarding the appropriate duration for driving restrictions after inappropriate implantable cardiac shock device (ICSD) therapy.Methods and Results:We evaluated Nippon Storm Study data, found that ICSD therapy occurred in 114 (7.6%) patients during a median follow-up of 464 days. Among those patients, 25 experienced further subsequent 380 Time-dependent recurrence 19 (76%) within 180 days.Conclusions:The interval can be reduced. (Circ J 2014; 78: 1989–1991)
Background: Cardiac resynchronization therapy (CRT) is effective in reducing morbidity and mortality systolic heart failure patients with cardiac dyssynchrony as demonstrated studies primarily Western populations. Although CRT devices a defibrillator (CRT-D) became available Japan since 2006, their efficacy remains uncertain Japanese patients. In this prospective, multicenter study, the of CRT-D an all-Japanese population was compared study conducted US, Multicenter InSync ICD Randomized...
Treatment of congestive heart failure (CHF) with loop diuretics, such as furosemide, may be associated complications, including worsening renal function and metabolic or electrolyte disturbances. Coadministration tolvaptan, a selective vasopressin V2 receptor antagonist, can ameliorate adverse events by reducing the required dose diuretics; however, safety tolvaptan in patients reduced is not known. As result, we conducted an exploratory clinical trial 22 CHF advanced chronic kidney disease...